Recombinant Macaca mulatta C-C motif chemokine 17 (CCL17) (Active)

CCL17 orchestrates T helper 2 cell recruitment to sites of allergic inflammation and immune regulation, making it a critical target for dissecting Th2-driven pathology in non-human primate models. This recombinant protein spans the full mature sequence (aa 24–94) and demonstrates robust receptor engagement, with an EC50 of 1.953–2.469 ng/mL in a functional ELISA using immobilized anti-CCL17 antibody, providing quantitative evidence that supports its use in chemotaxis assays, T cell migration studies, and signaling pathway investigations of CCR4-mediated responses. Endotoxin levels below 1.0 EU/μg meet the stringent thresholds required for primary immune cell assays, where even trace LPS contamination can confound cytokine-specific activation or differentiation readouts in PBMCs or purified T cell populations. Purity exceeding 95% by SDS-PAGE, combined with mammalian expression that preserves native glycosylation, aligns with standards expected for antibody development workflows, including use as an immunogen or coating antigen in ELISA validation.