Recombinant Mouse 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (Plcg2), partial

1. Syk-induced signals in bone marrow stromal cell lines are mediated by phospholipase C gamma1 (PLCgamma1) in osteogenesis and PLCgamma2 in adipogenesis. PMID: 28786489
2. Results show that mice with the mutated Plcg2 gene were less prone to transformation into MALT lymphomas as a result of elevated Treg numbers, and decrease of pro-inflammatory cytokines. PMID: 26966907
3. PLCgamma2 in clear cells plays an essential role in luminal expansion of the epididymis during the prepubertal period in mice PMID: 26950550
4. platelet activation through GPVI and alphaIIbbeta3 utilizes PLCgamma2 because PLCgamma1 levels are insufficient to support responsiveness, but that PLCgamma1 can restore responsiveness if expressed at levels normally achieved by PLCgamma2. PMID: 25793864
5. amarogentin prevents platelet activation through the inhibition of PLC gamma2-PKC cascade and MAPK pathway PMID: 24868545
6. PLCgamma2 and protein kinase C are important upstream signals that regulate myelopoiesis through cytokines. PMID: 24038146
7. inflammatory osteolysis can be abrogated by treatment with a molecule composed of the tandem SH2 domains of PLCgamma2. PMID: 24081142
8. down-regulation of PLCgamma2-beta-catenin pathway occurs in mice and humans and leads to myeloid-derived suppressor cells-mediated tumor expansion. PMID: 24127488
9. a novel role of the PLCgamma2-IP(3)-Ca(2+) cascade in the LPS-induced innate immune response pathway where release of intracellular Ca(2+) mediates TLR4 trafficking and subsequent activation of IRF3. PMID: 22158869
10. VapB positively regulates RANKL-mediated osteoclastogenesis via PLCgamma2-Ca(2+)-NFAT signaling PMID: 22245675
11. PLCgamma2 deficiency impairs Dectin-2-induced NF-kappaB and MAPK activation in response to fungal infection PMID: 22041900
12. These results suggest that the Plcg2-mediated pathways play a crucial role in various metabolic and sperm functions, in addition to initiating and maintaining the immune system. PMID: 21305534
13. Data indicate a role for PLCgamma2 and Ca(2+) signaling through the modulation of MEK/ERK in IL3/GM-csf stimulated mouse hematopoietic stem/progenitor cells. PMID: 21506110
14. Phosphatidylinositol-specific phospholipase C (PLC)-gamma was identified as a partner of the Spry1 and Spry2 proteins. PMID: 20719962
15. results demonstrate that the enzymatic activity of PLCgamma2 is tightly regulated to ensure efficient but limited platelet activation at sites of vascular injury PMID: 20230420
16. over expression of SH3BP2 in RAW 264.7 cells potentiates sRANKL-stimulated phosphorylation of PLCgamma1 and PLCgamma2. PMID: 20872577
17. Integrin alphaIIbbeta3 signaling via Src family kinases and Syk kinase to PLCgamma2 is required for megakaryocyte spreading, migration, and platelet formation. PMID: 20457868
18. study demonstrates a critical role for PLCgamma2 in eliciting inflammatory responses by regulating actin dynamics in DCs and positions the PLCgamma2 pathway as a common orchestrator of bone and immune cell functions during arthritis PMID: 20111715
19. PLCgamma2 is a critical regulator of the cellular and molecular mechanisms occurring in bone and immune cells during autoimmune inflammation. PMID: 20392227
20. The signaling pathway downstream of Syk divides into PLC2- and PI3K-dependent pathways. The activation of these pathways is controlled by the Tec family kinase Btk, which is required for E-selectin-mediated slow rolling. PMID: 20167705
21. Swip-1 provides a membrane scaffold that is required for the Syk-, SLP-65-, and PLCgamma2-dependent BCR-induced calcium flux. PMID: 20194721
22. Activation by GPVI and thrombin was unaltered in Vav1-, Vav2-, and Vav1/Vav2-deficient platelets. PMID: 12411320
23. PLC gamma 2 is expressed in mast cells and monocytes/macrophages and is activated by cross-linking of Fc epsilon and Fc gamma receptors. PMID: 12471105
24. PLC gamma 2 is not required for platelet aggregation. PMID: 12729897
25. PLCG2 has a signaling role in platelet glycoprotein Ib alpha calcium flux and cytoskeletal reorganization PMID: 12813055
26. PLCgamma2 plays not only a crucial role in activation of alphaIIbbeta3 by collagen receptors but also in alphaIIbbeta3-mediated responses. PMID: 12832411
27. the PLCgamma2 pathway provides a survival signal via regulation of Bcl-2 in all splenic B cell subpopulations and via additional induction of A1 in mature FO B cells PMID: 12928432
28. phospholipase C-gamma2 regulates RasGRP3 localization and thereby Ras activation. PMID: 14676298
29. While absence of PLCgamma2 had only a minimal effect on platelet adhesion to immobilized von Willebrand factor, its absence impaired spreading and profoundly affected thrombus growth and stability on VWF PMID: 15327970
30. results demonstrate that Vav3 and Vav1 play crucial but redundant roles in the activation of phospholipase C gamma 2 by glycoprotein GPVI PMID: 15456756
31. PLC-gamma2 is phosphorylated on Y753, Y759, and Y1217 in response to engagement of the B-cell receptor PMID: 15509800
32. signaling through PLCgamma2 plays an important role in arterial thrombosis, but that its contribution depends on the severity of the vascular lesion PMID: 15774906
33. M-CSF induces the translocation of PCLgamma2 to the cell membrane PMID: 15899577
34. Phospholipase C gamma 2 is crucial for development of the natural killer (NK) cell receptor repertoire and signaling of activating NK cell receptors, mediating optimal NK cell function in vivo. PMID: 16002670
35. The GPVI-PLCgamma2 activation pathway regulates collagen-dependent coagulation in venous and arterial thrombus formation. PMID: 16254207
36. Whereas PI3K functions upstream of PLCgamma2, activation of PLCgamma2 can occur independently of PI3K and that PI3K and PLCgamma2 also have distinct functions in BCR signal transduction. PMID: 16354682
37. BLNK-/- PLCgamma2-/- mice had compounded defects in B cell maturation compared with either single mutant, suggesting that these two molecules cooperatively or synergistically signaled B lymphopoiesis. PMID: 16585562
38. PLCgamma1 and PLCgamma2 play nonredundant and obligatory roles in NK cell ontogeny and in its effector functions. PMID: 17015722
39. Plays an important role in pre-B cell receptor-mediated early B-cell development. PMID: 17030619
40. in osteoclasts, PLCgamma2 formed a complex with the regulatory adapter molecule GAB2, was required for GAB2 phosphorylation, and modulated GAB2 recruitment to receptor activator of NF-kappaB PMID: 17053833
41. Bruton's tyrosine kinase and phospholipase C gamma 2 act both in concert and independently throughout B cell development. PMID: 17372989
42. activation of PLCgamma2 via glycoprotein 6 is dependent on 2 complementary events PMID: 17579183
43. Data demonstrate that the phospholipase Cgamma2 signaling pathway plays a role in activation of light-chain loci and contributes to receptor editing. PMID: 17591700
44. Data suggest that both the Vav family of Rho GTPase guanine nucleotide exchange factors and phospholipase C-gamma2 are critical mediators of adhesion-dependent reactive oxygen intermediate production by neutrophils in mice. PMID: 17932569
45. A key role for phospholipase C-gamma2 (PLCgamma2), Vav, B cell linker, and Bruton's tyrosine kinase in the formation of highly coordinated "microsignalosomes," , is identified.[ PMID: 18362175
46. PLCgamma2 influences Src activation by mediating the localization of Src to the integrin complex and thereby regulating integrin-mediated functions in the osteoclast. PMID: 18378693
47. GPVI-FcR gamma-chain, LAT and PLCgamma2 are essential for thrombus generation and stability PMID: 18464161
48. results demonstrate that Rac1 is essential for immunoreceptor tyrosine-based activation motif-dependent PLCgamma2 activation in platelets and that this is critical for thrombus formation in vivo PMID: 18704487
49. PLCgamma2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesis PMID: 18728019
50. The blood-lymph shunt observed in PLCgamma2-null mice was due to aberrant separation of blood and lymphatic vessels. A similar phenotype was observed in lethally irradiated wild-type mice reconstituted with PLCgamma2-null bone marrow cells. PMID: 19056831

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KEGG: mmu:234779

STRING: 10090.ENSMUSP00000079991

UniGene: Mm.192699