Recombinant Mouse Cyclic AMP-responsive element-binding protein 1(Creb1)

Code CSB-YP005947MO
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Source Yeast
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Code CSB-EP005947MO
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Source E.coli
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Code CSB-EP005947MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP005947MO
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Source Baculovirus
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Code CSB-MP005947MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Creb1
Uniprot No. Q01147
Alternative Names Creb1; Creb-1Cyclic AMP-responsive element-binding protein 1; CREB-1; cAMP-responsive element-binding protein 1
Species Mus musculus (Mouse)
Expression Region 1-341
Target Protein Sequence MTMESGADNQ QSGDAAVTEA ENQQMTVQAQ PQIATLAQVS MPAAHATSSA PTVTLVQLPN GQTVQVHGVI QAAQPSVIQS PQVQTVQSSC KDLKRLFSGT QISTIAESED SQESVDSVTD SQKRREILSR RPSYRKILND LSSDAPGVPR IEEEKSEEET SAPAITTVTV PTPIYQTSSG QYIAITQGGA IQLANNGTDG VQGLQTLTMT NAAATQPGTT ILQYAQTTDG QQILVPSNQV VVQAASGDVQ TYQIRTAPTS TIAPGVVMAS SPALPTQPAE EAARKREVRL MKNREAAREC RRKKKEYVKC LENRVAVLEN QNKTLIEELK ALKDLYCHKS D
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
Gene References into Functions
  1. Data show that cAMP-response-element binding protein (CREB) is a central molecular node in the circuit responses after stroke that lead to recovery from motor deficits. PMID: 29884780
  2. copper chelators regulate the balance between amyloidogenic and nonamyloidogenic processing of AbetaPP via promoting ADAM10 expression through MT1/2 /CREB-dependent signaling pathways. PMID: 29710396
  3. Creb1/Crtc1-3 and Sec14l3 could be important for early responses of the bronchial epithelium to Th2-stimuli. PMID: 28383034
  4. These findings suggest that dendritic region-specific morphological changes in CA1 neurons by constitutive activation of CREB may contribute to improved learning and STM. PMID: 28195219
  5. this study shows that CREB is a critical regulator of dendritic cells during the germinal center response PMID: 29854847
  6. FXR exerts its function in L cells through interacting with CREB, a crucial transcriptional regulator of cAMP-CREB signaling pathway, to inhibit its transcriptional activity. Targeting FXR to rescue GLP-1 secretion may be a promising strategy for type II diabetes. PMID: 29940597
  7. Antioxidative and Anti-Melanogenic Activities of Bamboo Stems (Phyllostachys nigra variety henosis) via PKA/CREB-Mediated MITF Downregulation in B16F10 Melanoma Cells PMID: 29385729
  8. Unexpectedly, although dispensable for FOXP3 expression and for the homeostasis and suppressive function of thymus-derived Treg cells, CREB negatively regulates the survival of TGF-beta-induced Treg cells, and deletion of CREB resulted in increased FOXP3+ Treg cells in the intestine and protection in a colitis model PMID: 29050947
  9. The absence of gut microbiota from birth was shown to be associated with decreased CREB expression, followed by decreases of protein kinase C beta (PRKCB) and AMPA receptors expression, and an increase of phosphorylation CREB (pCREB) expression. PMID: 27444685
  10. Findings suggest that cAMP response element binding protein -mediated hippoacampus structural plasticity is crucial for the role of 5-HT1a receptor in modulating anxiety-related behaviors. PMID: 27404655
  11. Significant CREB activation in almost the whole amygdala and hippocampus was observed after unconditioned stimulus-retrieval, but conditioned stimulus-retrieval only stimulated CREB activation in the lateral amygdala and the CA3 of hippocampus. In addition, propranolol, a beta-adrenergic receptor antagonist, treatment suppressed memory retrieval-induced CREB activation. PMID: 28848401
  12. Curc-mPEG454 reverses HFD-induced hepatic steatosis via the activation of CREB inhibition. PMID: 28770225
  13. Neuron-specific, adult-deletion of CREB1 alters hippocampal structures and causes neuropathological changes resembling aging brain. PMID: 28374133
  14. analysis of the molecular mechanisms through which CBP stability is regulated by FBXL19 and USP14, which results in the modulation of chromatin remodeling and the expression of cytokine-encoding genes PMID: 28611184
  15. the requirement of Creb1 for normal mammalian lung morphogenesis is not dependent upon its expression in lung epithelium or mesenchyme, nor its role in musculoskeletal development. PMID: 27150575
  16. data provide persuasive evidence towards the distinct roles of CREB within the dorsal and ventral hippocampus separately in mediating select nicotine withdrawal phenotypes. PMID: 27848935
  17. phosphorylation of CREB is downregulated in the Muller glia. PMID: 28331282
  18. Data suggest that the upregulation of mitochondrial respiratory chain proteins played a partial role in the protection of PKA/CREB signaling. PMID: 29038164
  19. Both CREB and deltaFosB play a role in the induction of this behavioural sensitization. PMID: 27147595
  20. LH induces MAPK3/1 and Akt activation, both of which are required for the CREB-promoted expression of EGF-like factors in granulosa cells. PMID: 27770611
  21. However, the mechanism that induces release of IL-6 from skeletal muscle cells remains unknown. Here we show that heat increases IL-6 in skeletal muscle cells through the transient receptor potential vannilloid 1, PKC, and cAMP response element-binding protein signal transduction pathway. PMID: 27979980
  22. NFIL3 functions as an important regulator of glucose homeostasis in the liver by limiting CREB-mediated hepatic gluconeogenesis PMID: 29132537
  23. Ca(2+) signaling pathway increases Nr4a1 expression in MA-10 Leydig cells, at least in part, by enhancing the recruitment of coactivator most likely through the MEF2, AP1, and CREB transcription factors thus demonstrating an important interplay between the Ca(2+) and cAMP pathways in regulating Nr4a1 expression. PMID: 26647388
  24. PGE2 serves as a central regulator of the Ren-1c gene in the principal cells of the kidney collecting ducts via the PKC/cAMP/CREB pathway. PMID: 28701311
  25. study revealed the involvement of CREB in B-1a cells, which was upregulated to increase the production of IL-10 for attenuating inflammation and organ injury, and finally improving survival during sepsis PMID: 28630091
  26. In conclusion, glucocorticoid couples mGR with Galphas and triggers cAMP-PKA-CREB axis dependent on the lipid raft to stimulate BACE1 upregulation and Abeta generation.SIGNIFICANCE STATEMENT Patients with Alzheimer's disease (AD) have been growing sharply and stress is considered as the major environment factor of AD. PMID: 28855330
  27. CREB was found to bind to GSK3beta promoter and essential for cAMP-mediated regulation of GSK3beta. PMID: 27190311
  28. The NR2B-CREB-miR212/132-CRTC1-CREB signal network plays an important role in the regulation of pain. PMID: 28244951
  29. Therefore, our study suggests that CREB and PSD95 are novel substrates of PERK, so inhibition of PERK phosphorylation using GSK2656157 would be beneficial against memory impairment after TBI. PMID: 28522733
  30. Our results elucidate the specific role of the transcription factors CREB, SRF, and MEF2 in the depression and potentiation components of ODP in vivo, therefore better informing future attempts to find therapeutic targets for diseases where activity-dependent plasticity is disrupted. PMID: 28607167
  31. Our study establishes a robust human stem cell-based platform for consistent quantitative evaluation of genotype-dependent Rett syndrome (RTT) phenotypes at the cellular level. PMID: 28270572
  32. neuronal activity promotes CREB-dependent transcription by increasing the frequency of CREB binding to highly localized genome locations PMID: 28053025
  33. The findings indicate that the activation of sigma1R can alleviate postpartum "depression" through increasing nNOS-NO-CREB activities. PMID: 27032391
  34. Data indicate that induction of a reactive oxygen species (ROS)/p38 MAPK - mediated feedback inhibitory pathway by oxy-cholesterol and steroid intermediates and products attenuates steroidogenesis via inhibition of cAMP responsive element binding protein (CREB) transcriptional activity. PMID: 28302174
  35. Activation of PTHrP-cyclic AMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance. PMID: 27070462
  36. We propose that phosphorylation-dependent regulation of DNA binding activity evolved as a tunable mechanism to control CREB transcriptional output and promote metabolic homeostasis in response to rapidly changing environmental conditions. PMID: 27431323
  37. The present study provides the first critical in vivo evidence showing a causal link between epigenetic modification of miR-10a mediated by HDAC3 and the development of diabetic nephropathy, and these results elucidate that HDAC3/miR-10a/CREB1 serves as a new mechanism underlying kidney injury, providing potential therapeutic targets in type 2 diabetes PMID: 27292126
  38. results identify new DNA sequences that are well-bound by CREB1 and ATF1 only when they contain 5mC or 5hmC. Analysis of two X-ray structures examines the consequences of 5mC and 5hmC on DNA binding by CREB and FOS|JUN PMID: 27951657
  39. We conclude that upon ligand binding, TLR4 activates PI3K/Akt signaling to induce F-spondin expression, subsequently control CREB-mediated IL-6 production to promote VSMC migration. These findings provide vital insights into the essential role of F-spondin in VSMC function and will be valuable for developing new therapeutic strategies against atherosclerosis. PMID: 27091427
  40. this paper shows that inhibition of autophagic flux regulates the alternation of microglial phenotype in cerebral ischemia by modulating the balance between NF-kappaB and CREB PMID: 27474951
  41. MeHg-induced neuronal degeneration is caused by site-specific neural hyperactivity triggered by the activation of MAPK and PKA/CREB pathways followed by c-fos and BDNF upregulation. PMID: 28267559
  42. protein expression level of MITF and p-CREB signaling pathway are significantly increased. Moreover, 60Hz ELF-EMFs reduce the phosphorylate of ERK in B16F10 melanoma cel PMID: 27543340
  43. results indicate that ETZ induces melanin synthesis via CREB phosphorylation. PMID: 27633503
  44. Oxytocin release and subsequent CREB phosphorylation are involved in the proconvulsant effects of acute sildenafil treatment in an experimental model of seizure. PMID: 27220266
  45. RACK1 plays an important role in the maintenance of morphine conditioned place preference, likely via activation of ERK-CREB pathway in hippocampus. PMID: 26830449
  46. Upregulation of CRTC1 enhancing CREB-dependent gene transcription in spinal cord may play an important role in bone cancer pain. PMID: 27060162
  47. In epileptic seizures mouse model, Pkdl deficiency leads to the loss of beta2AR on neuronal cilia, reduction in cAMP levels in the central nervous system, and reduction in the activation of cAMP response element-binding protein. PMID: 26612203
  48. CREB enhanced murine TR4 promoter activity via direct binding to a cAMP response element located in the promoter. PMID: 26762765
  49. the glucose-regulated antagonism between CREB and Sirt-1 for Hes-1 transcription participates in the metabolic regulation of neurogenesis. PMID: 26804914
  50. established a model in which FHL3 promotes the expression of MyHC 2a through CREB-mediated transcription and inhibits the expression of MyHC 1/slow by inhibiting MyoD transcription activity during myogenesis PMID: 26499038

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Subcellular Location Nucleus.
Protein Families BZIP family
Tissue Specificity Ubiquitously expressed.
Database Links

KEGG: mmu:12912

STRING: 10090.ENSMUSP00000059973

UniGene: Mm.422634

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