Recombinant Mouse Mitogen-activated protein kinase 10 (Mapk10)

1. JNK3 therefore provides a mechanism that contributes to homeostatic regulation of energy balance in response to metabolic stress. PMID: 26910012
2. Genetic inhibition of JNK pathway in vivo by Jnk3 knockout results in amelioration of spinal muscular atrophy phenotype PMID: 26423457
3. Rotenone induces dopamine neuron death through a series of sequential events including microtubule destabilization, JNK3 activation, VMAT2 inhibition, accumulation of cytosolic dopamine, and generation of ROS. PMID: 25496994
4. the data on anxiety, exploration and learning indicate that JNK1 ko mice displayed a stronger explorative behaviour and that knockout of JNK2 or JNK3 PMID: 23428746
5. JNK3 signaling is a major early pathway triggering retinal ganglion cell (RGC) death after axonal injury and may directly link axon injury to transcriptional activity that controls RGC death. PMID: 22353563
6. Deletion of JNK3 from Alzheimer (AD) mice results in a dramatic reduction in Abeta42 levels, overall plaque loads, and increased neuronal number and improved cognition, revealing AD as a metabolic disease under tight control by JNK3. PMID: 22958823
7. Mice deficient for neuron-specific isoform JNK3 have altered behavioural rhythms, with longer free-running period and compromised phase shifts to light. PMID: 22441692
8. Overall, our results show the transcriptional regulation of the MAPK pathway and the essential role of JNK in Japanese Encephalitis Virus-induced apoptosis in neuroblastoma cells. PMID: 21320173
9. This study indicated that the activation of PI3K/AKT pathway in hippocampus because of the increase in pik3cb transcription and that this mechanism is specifically related to the lack of Jnk3. PMID: 21255018
10. JNK2 and JNK3 are critically involved in stress-induced deficit of contextual fear, while JNK1 mainly regulates baseline learning in this behavioral task. PMID: 20926661
11. Results demonstrate that p75NTR-mediated activation of JNK3 is required for up-regulation of TACE, which promotes receptor proteolysis, leading to prolonged activation of JNK3 and subsequent apoptosis in sympathetic neurons. PMID: 20421303
12. Data show that neuritogenesis is delayed by lack of JNK2 and JNK3, but not JNK1. PMID: 20534829
13. JNK3 in neurons has a critical role in ischemic apoptosis PMID: 14657393
14. JNKs can mediate death independently of c-Jun PMID: 15528206
15. interaction of free arrestins with JNK3 and Mdm2 and their ability to regulate subcellular localization of these proteins may play an important role in the survival of photoreceptors and other neurons PMID: 16737965
16. Stimulation of ceramide biosynthesis seems to be under control of JNK3 signaling PMID: 17609208
17. MyD88-5 is distinct from other MyD88s in that MyD88-5 is preferentially expressed in neurons, colocalizes in part with mitochondria and JNK3, and regulates neuronal death. PMID: 17724133
18. JNK2/3 double deficiency blocks death due to retinoblastoma loss in both the PNS and CNS and In the medulla region of the hindbrain in the CNS, JNK2/3 deficiency blocks p53 activation. PMID: 17984095
19. data identify JNK3 as a critical mediator of pathogenic Htt (polyQ-Htt)toxicity and provide a molecular basis for polyQ-Htt-induced inhibition of fast axonal transport. PMID: 19525941
20. The activation of SAPK/JNK in basket cell "pinceaux" may be a consequence of altered functionality of Purkinje cells and may represent an attempt of basket cells of synaptic remodeling. PMID: 19703431

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KEGG: mmu:26414

STRING: 10090.ENSMUSP00000108468

UniGene: Mm.39253