MAPK10

Mitogen-activated protein kinase 10 is a protein in humans that is encoded by MAPK10 gene. Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2.

MAPK10 Antibodies

MAPK10 Antibodies for Homo sapiens (Human)

MAPK10 Antibodies for Human

MAPK10 Proteins

MAPK10 Proteins for Rattus norvegicus (Rat)

MAPK10 Proteins for Homo sapiens (Human)

MAPK10 Proteins for Mus musculus (Mouse)

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