MAPK10

The following MAPK10 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

MAPK10 Antibodies

MAPK10 Antibodies for Homo sapiens (Human)

MAPK10 Proteins

MAPK10 Proteins for Rattus norvegicus (Rat)

MAPK10 Proteins for Homo sapiens (Human)

MAPK10 Proteins for Mus musculus (Mouse)

MAPK10 Background

The MAPK10 gene encodes the mitogen-activated protein kinase 10, an enzyme also known as c-Jun N-terminal kinase 3 (JNK3) [1][2]. JNK3 expression is largely restricted to the brain, heart, and testis [3]. As a serine/threonine-protein kinase, MAPK10/JNK3 is involved in various processes such as neuronal proliferation, differentiation, migration, and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates many transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity, eventually inducing cell proliferation, differentiation and stress responses [2][4-6]. Targeted deletion of JNK3 not only reduces the stress-induced JNK activity but also protects mice from a brain injury after cerebral ischemia–hypoxia [7]. The downstream mechanism of JNK3-mediated apoptosis may include the induction of Bim and Fas and the mitochondrial release of cytochrome c [7]. These results suggest that JNK3 is a potential target for neuroprotection therapies in stroke [7].

[1] Yoshida S, Harada H, et al. Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and seven polymorphisms of the FAP-1 gene [J]. J. Hum. Genet. 2002, 47 (11): 614-9.
[2] Gupta S, Barrett T, et al. Selective interaction of JNK protein kinase isoforms with transcription factors [J]. EMBO J. 1996, 15 (11): 2760-70.
[3] Davis RJ. Signal transduction by the JNK group of MAP kinases.
Cell 2000;103:239-252.
[4] Dérijard B, Hibi M, et al. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 1994, 76: 1025-1037.
[5] Kyriakis J, Banerjee P, The stress-activated protein kinase subfamily of c-Jun kinases. Nature 1994, 369: 156-160.
[6] Nishina H, Wada T, et al. Physiological roles of SAPK/JNK signaling pathway. J Biochem. 2004 Aug;136(2):123-6.
[7] Chia-Yi Kuan, Alan J. Whitmarsh, et al. A critical role of neural-specific JNK3 for ischemic apoptosis [J]. Proc Natl Acad Sci U S A. 2003 Dec 9; 100(25): 15184-15189.

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