||Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. Promotes keratinocyte terminal differentiation (By similarity). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles.
||Cytoplasm, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole, Golgi apparatus membrane, Peripheral membrane protein, Cell projection, bleb, Cytoplasm, cytoskeleton, Cell membrane, Cell projection, lamellipodium, Cell projection, ruffle
||Protein kinase superfamily, AGC Ser/Thr protein kinase family
||Highly expressed in brain, heart, lung, liver, stomach, spleen, kidney, testis, muscle, embryo and placenta.
cAMP signaling pathway
Chemokine signaling pathway
TGF-beta signaling pathway
Regulation of actin cytoskeleton
Vascular smooth muscle contraction
Leukocyte transendothelial migration
cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Inhibitors of axonal regeneration