Recombinant Mouse Rho-associated protein kinase 1 (Rock1), partial

1. by differentially affecting CyPA and Bsg expressions, ROCK1 protects and ROCK2 jeopardizes the heart from pressure-overload heart failure with postcapillary pulmonary hypertension, for which celastrol may be a promising agent. PMID: 29987023
2. Data indicate that Rho-associated protein kinase (ROCK)-dependent intermittent T cell migration regulates tissue-sampling during acute lung injury. PMID: 29044117
3. findings are the first to show that astrocytes exposed to MeHg showed increased cleavage/activation of ROCK-1, which was independent of the small GTPase RhoA PMID: 29428217
4. the transcription of Rho-associated coiled-coil containing protein kinase 1 (ROCK1), which phosphorylates Drp1 at Ser616, was shown by luciferase assay to be directly regulated by FOXO1. These findings suggested that FOXO1 is critical to preserve mitochondrial quantity and function in ECs, and FOXO1 may serve as a therapeutic target for microvascular complications of diabetes. PMID: 29654945
5. A specific inhibitor of ROCK, Y-27632, was used to examine the role of ROCK in mouse colitis models. ROCK1 and ROCK2 were silenced respectively using RNA interference in Caco-2 cells. The expression of tight junction proteins and the downstream molecules of ROCK were assessed PMID: 29115372
6. GTP-RhoA and ROCK1 expression levels were markedly increased in a time-dependent manner in the ears and lungs of mice treated with penicillin. PMID: 27619816
7. Irisin replenishment in mCaROCK1 mice partially reversed insulin resistance. PMID: 27411515
8. MicroRNA-146a suppresses ROCK1 allowing hyperphosphorylation of tau in Alzheimer's disease PMID: 27221467
9. Fasudil exhibited protective effects on smoke exposure induced cognitive deficits which might involve with the regulation of Rho/ROCK/NF-kappaB pathways. PMID: 27791202
10. Dexamethasone up-regulates ROCK1/2 activity promoting migration, invasion and metastasis of melanoma cells. PMID: 28923399
11. mDia induces circumferential actin filaments around the edge of the synaptic cleft, which contract the presynaptic terminals in a ROCK-dependent manner. PMID: 27880913
12. SNRK in cardiomyocytes is responsible for maintaining cardiac metabolic homeostasis, which is mediated in part by ROCK, and alteration of this homeostasis influences cardiac function in the adult heart. PMID: 27780848
13. we uncovered cell state plasticity and adhesion dynamics regulated by Ror2, which influenced Ras Homology Family Member A (RhoA) and Rho-Associated Coiled-Coil Kinase 1 (ROCK1) activity downstream of Dishevelled-2 (Dvl2). PMID: 28650466
14. Data indicate that oxidative stress in diabetes causes a decrease in miR-133a expression leading to an increase in RhoA/Rho kinase pathway and muscle contraction. PMID: 28678840
15. that reduction of ROCK1 diminishes amyloid-beta levels by enhancing Amyloid beta-Protein Precursor protein degradation PMID: 27246255
16. the cross-talk between canonical and non-canonical signaling pathways of Wnt3A, which induces GSK-3beta phosphorylation and beta-catenin accumulation through RhoA and ROCK activation. PMID: 27575935
17. Inhibition of ROCK1 largely blocked Endothelial-to-mesenchymal transition and the increase in endothelial permeability under this high-glucose condition, but overexpression of ROCK1 induced these changes. PMID: 26842599
18. While the loss of either Rock1 or Rock2 had no negative impact on tumorigenesis in mouse models of non-small cell lung cancer and melanoma, loss of both blocked tumor formation, as no tumors arise in which both Rock1 and Rock2 have been genetically deleted. PMID: 26765561
19. YQFM ameliorates the OGD-induced brain microvascular endothelial cell barrier disruption associated with the NF-kappaB/p65 and ROCK1/MLC signaling pathways. PMID: 26915982
20. Extracellular vesicle-encapsulated caspase-3 was largely responsible for the alveolar macrophage activation via the ROCK1 pathway. PMID: 26658190
21. In experimental autoimmune encephalomyelitis (EAE), ROCK activity was also increased in serum, spleen, brain and spinal cord. Neuron injury with scratch and TNF-alpha stimulation induced the up-regulation of ROCK activity. PMID: 26481340
22. indicates that the up-regulation of ROCK1 activity in RhoA-deleted macrophages and macrophage phenotype/polarity are dependent on non-apoptotic Caspase-3 PMID: 26875770
23. Rho-kinase-dependent actin turnover and actomyosin disassembly are necessary for mouse spinal neural tube closure. PMID: 26040287
24. Results suggest that Rho-associated, coiled-coil containing protein kinase (ROCK) inhibitors fasudil may be an emerging therapeutic option for targeting cancer vasculogenic mimicry (VM). PMID: 25934709
25. doxorubicin induces caspase activation, necrosis, and actin cytoskeleton alterations largely through ROCK1-dependent and oxidative stress-independent pathways PMID: 26134406
26. A very rapid reduction in p27-phospho-Ser10 levels at the onset of atherogenesis, which contributes to early plaque build-up through RhoA/ROCK-induced integrin expression, is reported. PMID: 25908026
27. RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock. PMID: 25857352
28. ROCK1-dependent changes in hyaluronan may contribute to ROCK1's role in O3-induced AHR, the role of ROCK2 is downstream of inflammation, likely at the level of airway smooth muscle contraction. PMID: 26276827
29. The results showed that ROCK was essential for early embryo cleavage and blastocyst formation, possibly through a conserved ROCK-LIMK1/2-actin pathway, during mouse embryo development. PMID: 24562870
30. The role of Rho-kinase in leukocytes during ischemia/reperfusion injury. PMID: 24638037
31. Proper inner cell mass morphology is dependent on ROCK activity and is crucial for fetal development. PMID: 23946538
32. Data indicate that transient receptor potential melastatin subtype 8 (TRPM8) activation by menthol attenuated vasoconstriction via RhoA/Rho kinase pathway inhibition in wild-type mice, but the effect was absent in TRPM8(-/-) mice. PMID: 24637663
33. Adipose ROCK1 isoform plays an inhibtory role for the regulation of insulin sensitivity in diet-induced obesity in vivo. PMID: 24326423
34. Rho kinase inhibition enhances the survival of newborn neurons in the dentate gyrus. PMID: 23707981
35. ROCK1(-/-) MEFs showed significant preservation of both focal adhesions and adherens junctions. PMID: 23598717
36. Data from transgenic/knockout mice suggest loss of Rock1 in AgRP (agouti-related peptide) neurons of arcuate nucleus leads to decrease in energy expenditure/locomotor activity independent of change in food intake and thus leads to obesity/adiposity. PMID: 23885017
37. the two isoforms of Rho-kinase distribute differentially to accomplish their specific functions PMID: 22986902
38. Rock1 displays specific control of endothelial cell survival. PMID: 22934846
39. ROCK1 is involved in destabilizing actin cytoskeleton through regulating MLC2 phosphorylation and peripheral actomyosin contraction. PMID: 23392171
40. ROCK inhibition diminishes most microglial activation properties, such as the increased cell body size, number of filopodial processes and size of Golgi apparatus, after MPTP insult. PMID: 23139861
41. data identify ROCK1 as a key regulator of leptin action on energy homeostasis. PMID: 22941110
42. Rock is thus essential for survival of neural crest cells that form the craniofacial region. PMID: 22629443
43. ROCK1 functions as a physiologic regulator of p53 under conditions of erythroid stress. PMID: 22889758
44. Rho-kinase signaling constitures a key feature in streptococcal M1 protein induced acute lung injury. PMID: 22433673
45. our overall results reveal a model whereby CD1d-mediated Ag presentation is negatively regulated by ROCK1 and ROCK2 via its effects on the actin cytoskeleton. PMID: 22798677
46. Data suggest that small artery dysfunction in diabetes involves suppression of extracellular glucose dependency of vasoconstriction under hyperglycemic conditions; this dysfunction appear to involve reduced Rho kinase expression. PMID: 22465314
47. a novel mechanism in which miR-148a positively regulates myogenic differentiation via ROCK1 down-regulation. PMID: 22547064
48. Regulation of glucose transport by ROCK1 differs from that of ROCK2 and is controlled by actin polymerization. PMID: 22355071
49. conclude that ROCKDelta1 is a novel fibrotic factor. Activation of TGFbeta1 and NF-kappaB signaling contributes to the Rho kinase-mediated pathological fibrosis PMID: 22278938
50. Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells. PMID: 22326220

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KEGG: mmu:19877

STRING: 10090.ENSMUSP00000069549

UniGene: Mm.6710