Recombinant Mouse Transforming protein RhoA (Rhoa)

1. KLF4 indirectly modulates the actin cytoskeleton morphology via activity of RhoA in order to inhibit cellular migration and invasion. PMID: 29498307
2. Cdc42 and RhoA act as a regulatory circuit downstream of the megakaryocytes -specific mechanoreceptor GPIb to coordinate polarized transendothelial platelet biogenesis. PMID: 28643773
3. Non-visual arrestins regulate the focal adhesion formation via small GTPases RhoA and Rac1 independently of G-protein-coupled receptors. PMID: 29133163
4. RHOA loss reduces YAP signaling of the Hippo pathway and affects YAP effector epiregulin (EREG) expression in the crypts. Expression of an active YAP (S112A) mutant rescues ntestinal stem cells (ISCs) marker expression, ISC regeneration, and ISC-associated Wnt signaling, but not defective epithelial polarity, in RhoA knockout mice, implicating YAP in RHOA-regulated ISC function. PMID: 29129684
5. GTP-RhoA and ROCK1 expression levels were markedly increased in a time-dependent manner in the ears and lungs of mice treated with penicillin. PMID: 27619816
6. Tyr42 phosphorylation of RhoA GTPase promotes tumorigenesis through NF-kappaB. PMID: 28712859
7. RhoA modulates the choices of molar cuspal shape by coordinating adhesion junctions, actin distribution, and fibronectin localization to drive inner dental epithelium invagination. PMID: 27892530
8. Kctd13 deletion reduces synaptic transmission, which correlates with increased levels of RhoA, a KCTD13/CUL3 ubiquitin ligase substrate PMID: 29088697
9. Crmp4(-/-) OBs exhibited enhanced activation of RhoA/focal adhesion kinase (FAK) signaling that led to cytoskeletal changes with increased cell spreading. PMID: 28019696
10. Codepletion of the actomyosin regulator RhoA and Afadin results in defects in the central lumens and arrests lumen remodeling PMID: 29330353
11. Hydrogen peroxide oxidizes RhoA at Cys16 and Cys20, and activates RhoA via Vav2. PMID: 27974245
12. These results reveal a novel signaling network, the Sema4D-RhoA-Akt signal cascade, that coordinates cellular function and morphology and highlights the importance of specific spatiotemporally restricted components of a signaling pathway in the regulation of ameloblast differentiation. PMID: 27218883
13. RhoA deficiency could disrupt podocyte cytoskeleton and induce podocyte apoptosis by inhibiting YAP/dendrin signal. PMID: 27389190
14. These results suggested that, in addition to inhibiting Noggin transcription, RhoA activity in wild-type murine embryonic stem cells also prevented neural differentiation by limiting Noggin secretion. PMID: 27460990
15. Rho attenuates the interaction between Amot and Nf2 by binding to the coiled-coil domain of Amot. PMID: 28947533
16. we uncovered cell state plasticity and adhesion dynamics regulated by Ror2, which influenced Ras Homology Family Member A (RhoA) and Rho-Associated Coiled-Coil Kinase 1 (ROCK1) activity downstream of Dishevelled-2 (Dvl2). PMID: 28650466
17. Active Rho-kinase diffuses to growing other immature neurites and inhibits their outgrowth to ensure single axon formation. PMID: 28652571
18. Data indicate that oxidative stress in diabetes causes a decrease in miR-133a expression leading to an increase in RhoA/Rho kinase pathway and muscle contraction. PMID: 28678840
19. Downregulation of Cul3 led to a marked increase in RhoA protein expression after 6 days of adipocytes differentiation, suggesting that Cul3 is involved in the regulation of RhoA stability. PMID: 28499918
20. Impaired denitrosylation is associated with detrusor overactivity, which is linked with upregulated RhoA/Rho-kinase signalling PMID: 28303627
21. The in vivo function of RhoA in corpus luteum (CL) luteal cell cytoskeleton integrity, cholesterol transport, StAR expression, and progesterone synthesis, and a positive feedback on StAR expression in CL by progesterone signaling. PMID: 28498971
22. Reveal novel intracellular signaling mechanisms involving RhoA/STAT3 underlying the contribution of reactive astrocyte dynamics to glial scar formation. PMID: 28642362
23. P311 could accelerate skin wound reepithelialization by promoting the migration of Epidermal Stem Cell through RhoA and Rac1 activation. PMID: 27927130
24. We show that RhoA mRNA levels were significantly higher compared with the RhoB mRNA levels in ESCs as well in various cancer cell lines and this difference could be accounted for by differences in the activities of the corresponding promoters. PMID: 28739254
25. Results strongly support the hypothesis that spinal RhoA/ROCK signaling plays a central role in the neuropathic pain. In addition, simvastatin might exert its antihyperalgesic and antiallodynic effects through the attenuation of sensitization of spinal nociceptive transmission that is modulated by mechanisms dependent on the RhoA/ROCK signaling. PMID: 27457035
26. Findings suggest that atorvastatin attenuates diabetes-associated renal injury by reducing reactive oxygen species (ROS) generation, RhoA activity and normalizing Akt/GSK3beta signaling pathways. PMID: 27649495
27. findings describe a novel RhoA regulatory mechanism. PMID: 27992599
28. ANXA1 restores Abeta42-induced blood brain barrier disruption through inhibition of RhoA-ROCK signaling pathway PMID: 27633771
29. study delineates a mechanism in which NCAM promotes ephrin-A5-dependent clustering of EphA3 through interaction of the NCAM Ig2 domain and the EphA3 CRD, stimulating EphA3 autophosphorylation and RhoA signaling necessary for growth cone repulsion in GABAergic interneurons in vitro, which may extend to remodeling of axonal terminals of interneurons in vivo. PMID: 27803162
30. M0 and M2 macrophages have a radically different phenotype and polarity from M1 macrophages, and that this is mirrored in dissonant response to RhoA pathway interference. PMID: 27628094
31. the cross-talk between canonical and non-canonical signaling pathways of Wnt3A, which induces GSK-3beta phosphorylation and beta-catenin accumulation through RhoA and ROCK activation. PMID: 27575935
32. these findings reveal that Arhgef1 functions as a negative regulator of neurite outgrowth through regulating RhoA-cofilin pathway and actin dynamics. PMID: 27489999
33. presentation of a form of biochemical computation in dendrites involving the controlled complementation of three molecules--Rac1, RhoA and Cdc42--that simultaneously ensures signal specificity and primes the system for BDNF-dependent homo- and heterosynaptic plasticity PMID: 27680697
34. The transcriptional co-activator MRTF-A was activated by sphingosine-1-phosphate as assessed by its nuclear accumulation and induction of a RhoA/MRTF-A luciferase reporter. PMID: 27094722
35. In conclusion, these results indicate the sub-chronic ethanol treatment decreased the expression of RhoA in mouse corpus cavernosum PMID: 26728616
36. RhoA-PLD1 signaling is involved in acidic extracellular pH-induced matrix metalloproteinase-9 in mouse metastatic B16-BL6 melanoma cells PMID: 26782071
37. Caspase-11 targets cofilin via the RhoA GTPase, whereas caspase-1 engages the Slingshot phosphatase PMID: 26686473
38. RhoA determines lineage fate of mesenchymal stem cells by modulating CTGF-VEGF complex in extracellular matrix. PMID: 27126736
39. TcdB proteins target Rac, Cdc42, Rap, and R-Ras and glucosylates RhoA. PMID: 26755157
40. In cultured neonatal cardiac fibroblasts, p63RhoGEF regulated the angiotensin II (Ang II)-dependent RhoA activation, the activation of the serum response factor, and the expression and secretion of CTGF. PMID: 26392029
41. Inhibition of the RhoA/Rock2 kinase pathway prevents lipopolysaccharide-induced hyperalgesia and the release of TNF-alpha and IL-1beta in the mouse spinal cord. PMID: 26416580
42. indicates that the up-regulation of ROCK1 activity in RhoA-deleted macrophages and macrophage phenotype/polarity are dependent on non-apoptotic Caspase-3 and are sensitive to Caspase-3 inhibition PMID: 26875770
43. These findings uncover deficient prenylation of Rho-A as a key player in the pathogenesis of IBDs. PMID: 26752649
44. In summary, the dihydroxycoumarin derivative daphnetin inhibits the invasion and migration of LM8 cells, and therefore represents a promising agent for use against metastatic cancer. PMID: 26845352
45. Spindle organization and actin assembly are regulated through a RhoA-FMNL1-GM130 pathway in oocyte meiosis. PMID: 26083584
46. The results provide a starting point to dissect spatiotemporal Rhoa GTPase signaling networks that regulate neurite outgrowth. PMID: 26728857
47. Soluble beta-amyloid disrupts actin and microtubule dynamics via activation of RhoA and inhibition of histone deacetylase 6 in cultured hippocampal neurons. PMID: 26198811
48. A very rapid reduction in p27-phospho-Ser10 levels at the onset of atherogenesis, which contributes to early plaque build-up through RhoA/ROCK-induced integrin expression, is reported. PMID: 25908026
49. Findings indicate GTPase RhoA as a central regulator of dendritic cells (DCs) homeostasis. PMID: 26408665
50. Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP) as a novel component of neuronal synapses whose absence increases dendritic spine size and filamentous actin levels in an N-WASP/Arp2/3-independent, RhoA/ROCK/profilinIIa-dependent manner. PMID: 24698977

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KEGG: mmu:11848

STRING: 10090.ENSMUSP00000007959

UniGene: Mm.318359