Phospho-PTPRC (Ser1007) Antibody

Datasheet
Code CSB-PA446974
Product Type Polyclonal Antibody
Former Code(s) CSB-PA583457
Size US$360
Uniprot No. P08575
Image
  • Western blot analysis of extracts from HeLa cells treated with TNF using Phospho-CD45 (Ser1007) antibody.The lane on the right is treated with the antigen-specific peptide.
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunogen Peptide sequence around phosphorylation site of serine 1007 (D-D-S(p)-D-S) derived from Human CD45.
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Specificity The antibody detects endogenous level of CD45 only when phosphorylated at serine 1007.
Tested Applications ELISA,WB;WB:1:500-1:1000
Relevance

Protein binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity; protein kinase binding.

Wang Y, Guo W, Liang L, Esselman WJ (1999)J Biol Chem 274, 7454-61.

Form Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Clonality Polyclonal
Alias L-CA; LY-5; Leukocyte common antigen precursor; PTPRC; T200
Immunogen Species Homo sapiens (Human)
Target Names PTPRC
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
Involvement in disease Severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID); Multiple sclerosis (MS)
Subcellular Location Membrane, Single-pass type I membrane protein, Membrane raft
Protein Families Protein-tyrosine phosphatase family, Receptor class 1/6 subfamily
Database Links

HGNC: 9666

OMIM: 126200

KEGG: hsa:5788

STRING: 9606.ENSP00000356346

UniGene: Hs.654514

Pathway Fc gamma R-mediated phagocytosis
T cell receptor signaling pathway

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