All
  • All
  • ELISA Kit
  • Protein
  • Antibody
  • Molecular Biology Product
  • Small Molecule
  • Peptide
All
  • All
  • ELISA Kit
  • Protein
  • Antibody
  • Molecular Biology Product
  • Small Molecule
  • Peptide

CD79A Recombinant Monoclonal Antibody

Promotion
Datasheet
Code CSB-RA004957MA1HU
Size $49.9
Order now
Promotion
CUSABIO Limited Time Offer: 3,000+ Abs from $49.9/100µg or $49.9/100ul.
Image
  • The Binding Activity of Human CD79A with Anti-CD79A recombinant antibody
    Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD79A(CSB-MP004957HU1) at 2 μg/mL can bind Anti-CD79A recombinant antibody. The EC50 is 1.521-1.700 ng/mL.
  • The Binding Activity of Human CD79A&CD79B with Anti-CD79A recombinant antibody
    Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD79A&CD79B(CSB-MP5861HU) at 2 μg/mL can bind Anti-CD79A recombinant antibody. The EC50 is 8.012-9.339 ng/mL.
  • The purity of CD79A was greater than 95% as determined by SEC-HPLC
  • The Binding Activity of Human CD79A with Anti-CD79A recombinant antibody
    Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD79A(CSB-MP004957HU1p6) at 2 μg/mL can bind Anti-CD79A recombinant antibody. The EC50 is 14.44-16.80 ng/mL.
  • Untransfected HEK-293T cells (green line) and transfected Human CD79A&CD79B HEK-293T stable cells (red line) were stained with anti-CD79A antibody(CSB-RA004957MA1HU) (2µg/1*106cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
  • Untransfected HEK-293T cells (green line) and transfected Human CD79A HEK-293T pool cells (red line) were stained with anti-CD79A antibody(CSB-RA004957MA1HU) (2µg/1*106cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Uniprot No.
P11912
Target Names
CD79A
Alternative Names
B lymphocyte-specific MB1 protein antibody; B-cell antigen receptor complex-associated protein alpha chain antibody; CD 79a antibody; CD79a antibody; CD79a antigen (immunoglobulin-associated alpha) antibody; CD79A antigen antibody; CD79a molecule; immunoglobulin-associated alpha antibody; CD79A_HUMAN antibody; Ig alpha antibody; Ig-alpha antibody; IGA antibody; IgM-alpha antibody; Immunoglobulin-associated alpha antibody; Ly54 antibody; MB-1 membrane glycoprotein antibody; MB1 antibody; Membrane-bound immunoglobulin-associated protein antibody; Surface IgM-associated protein antibody
Species Reactivity
Human
Immunogen
Recombinant Human CD79A protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Monoclonal
Isotype
hIgG1
Clone No.
6F5
Purification Method
Affinity-chromatography
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, FC
Recommended Dilution
Application Recommended Dilution
ELISA 1:5000-1:50000
FC 1:50-1:200
Protocols
ELISA Protocol
Flow Cytometry (FC) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description

CD79A serves as an essential component of the B-cell antigen receptor complex, where it pairs with CD79B to form the signaling module that transduces activation signals following antigen recognition. This membrane glycoprotein plays a fundamental role in B-cell development, activation, and differentiation, making it a critical marker for studying B-cell biology, lymphoma classification, and immune system function.

This recombinant monoclonal antibody, clone 6F5, offers researchers the consistency and reliability that comes with sequence-defined production. Unlike traditional hybridoma-derived antibodies, recombinant technology ensures lot-to-lot reproducibility, giving you confidence that your experimental results will remain comparable across studies and over time. The human IgG1 isotype format and affinity-chromatography purification deliver a reagent with greater than 95% purity as confirmed by SEC-HPLC analysis.

Validation studies demonstrate robust performance across multiple experimental platforms. In functional ELISA assays, this antibody binds immobilized human CD79A with an EC50 in the low nanogram per milliliter range, confirming high-affinity target recognition. Notably, the antibody also recognizes CD79A when complexed with its natural partner CD79B, reflecting its utility in studying the physiologically relevant heterodimer. Flow cytometry validation using HEK-293T cells transfected with either CD79A alone or the CD79A/CD79B complex shows clear discrimination between transfected and untransfected populations, demonstrating specificity for cell surface detection applications.

The antibody is supplied in a glycerol-based PBS buffer optimized for long-term storage stability. For researchers investigating B-cell malignancies, immunodeficiencies, or fundamental aspects of adaptive immunity, this antibody provides a dependable tool for characterizing CD79A expression and function in human samples.

Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Related Products

CD79A Antibodies

CD79A Proteins

Customer Reviews and Q&A

■ Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.
Gene References into Functions
  1. The incidence of MYD88 and CD79B mutations in patients with CD5(+) DLBCL is lower than that in patients with DLBCL-SS, suggesting that CD5(+) DLBCL is not the same disease as DLBCL-SS in terms of gene mutation status. PMID: 27915469
  2. Phosphorylation of CD79a causes a decrease in helical propensity in the C-terminal region, for CD79b, the opposite was observed and phosphorylation resulted in an increase of helical propensity in the C-terminal part. PMID: 24769851
  3. High intensity of caries is associated with increased levels of some salivary components - sIgA, histatin-5 and lactoperoxidase. PMID: 24974109
  4. CD79a plays a functional role in the tumor promoting effects of myeloid cells, and may represent a novel target for cancer therapy. PMID: 24146823
  5. STN produced significant antitumor effects in a mouse xenograft model of CD79A/B-mutated DLBCL. PMID: 21324920
  6. CD79a may be helpful marker in the differential diagnosis of classical Hodgkin's lymphoma and primary mediastinal B-cell lymphoma PMID: 20102401
  7. Unlike the B29 octamer motif, the mb-1 octamer motif does not have the essential sequence required for OBF-1/Bob1 interaction, therefore its promoter is not transactivated by OBF-1/Bob1. PMID: 11907094
  8. B cell-restricted mb-1 gene: expression, function, and lineage infidelity. Review. PMID: 12403343
  9. There is a somatic hypermutation of this gene in B-cell lymphoma and multiple myeloma. PMID: 12651942
  10. Results indicate that PAX5 is a more specific marker than CD79a for B-cell ALL diagnosis. PMID: 15492262
  11. lower levels of B-cell receptor surface expression observed in chronic lymphocytic leukemia are accounted for by an impaired glycosylation and folding of the mu and CD79a chains. PMID: 15591116
  12. FISH findings indicate that CD79a, despite its specificity for B-cell differentiation, represented the aberrant presence of a B-cell antigen in leukemias of distinct myeloid linage. PMID: 16271957
  13. Acute leukemia with t(8;21) coexpresses CytCD79a represent biphenotypic acute leukemia. PMID: 17350472
  14. Anti-CD79b antibodies downregulated surface B-cell receptor and were trafficked to the lysosomal-like major histocompatibility complex class II-positive compartment of a mouse xenograft model of non-Hodgkin lymphoma. PMID: 17374736
  15. Ig-alpha was phosphorylated in all myeloma IgG BCR isolates, the 31-kD variant being phosphorylated most frequently. It was not phosphorylated in normal control B cells. PMID: 17701175
  16. Median survival time of cytoplasmic CD79 alpha positive group was shorter than that of cytCD79a negative group in acute myeloid leukemia. PMID: 18160827

Show More

Hide All

Involvement in disease
Agammaglobulinemia 3, autosomal recessive (AGM3)
Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Tissue Specificity
B-cells.
Database Links

HGNC: 1698

OMIM: 112205

KEGG: hsa:973

STRING: 9606.ENSP00000221972

UniGene: Hs.631567

Promotions
Reward For Reviews
Free antibody trial
Contact Us

  Email: [email protected]
  Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Related Articles
CD79A and CD79B: Key Targets in B Cell Signaling Pathways and Therapeutic Potential Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?
Related pathways
B cell receptor signaling pathway Cell markers Target Therapy
CUSABIO guaranteed quality
icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of email
Email
[email protected]
icon of address
Address
No. 269, Shendun 5th Road, Donghu Hi-Tech Development Area, Hubei Province, 430206, P.R.China
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2026 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
Privacy Policy
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*