CD79A, also referred to as MB-1, is the alpha chain of the B-cell antigen receptor complex. This 47 kDa membrane glycoprotein pairs with CD79B to form the heterodimeric B cell receptor (BCR), which is crucial for B cell signaling and subsequent activation, apoptosis, or allergic responses. CD79A's primary function is to facilitate signal transduction in conjunction with CD79B; when an antigen binds to the BCR, the CD79A/CD79B heterodimer transmits activation signals that trigger B cell proliferation, differentiation, and antibody production. The cytoplasmic region of CD79A contains the immune receptor tyrosine activating motif (ITAM), a critical structure for signal transduction. CD79A plays a vital role in B cell function, including antigen recognition, activation, proliferation, and differentiation. Additionally, its expression is linked to the development of certain B-cell tumors, such as B-cell acute lymphoblastic leukemia (B-ALL). Therefore, CD79A is a significant target for research and therapeutic interventions in B cell biology and related diseases.
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CD79A at 2 μg/ml can bind Anti-CD79A recombinant antibody(CSB-RA004957MA1HU). The EC50 is 1.521-1.700 ng/mL.
CD79A Recombinant Monoclonal Antibody (CSB-RA004957MA1HU)
Validated Data
The Binding Activity of Human CD79A with Anti-CD79A recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD79A(CSB-MP004957HU1) at 2 μg/mL can bind Anti-CD79A recombinant antibody. The EC50 is 1.521-1.700 ng/mL.
The Binding Activity of Human CD79A&CD79B with Anti-CD79A recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD79A&CD79B(CSB-MP5861HU) at 2 μg/mL can bind Anti-CD79A recombinant antibody. The EC50 is 8.012-9.339 ng/mL.
The purity of CD79A was greater than 95% as determined by SEC-HPLC
The following CD79A reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
CD79A Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA165334 | CD79A Antibody | Human | ELISA,WB |
CSB-PA080055 | CD79A Antibody | Human | WB, ELISA |
CSB-PA080056 | CD79A Antibody | Human,Mouse | WB, ELISA |
CSB-PA780889 | CD79A Antibody | Human,Mouse | ELISA,WB |
CSB-PA183306 | CD79A Antibody | Human,Mouse | ELISA,WB |
CSB-PA004957LC01HU | CD79A Antibody, FITC conjugated | Human | |
CSB-PA004957LA01HU | CD79A Antibody | Human | ELISA, IHC, IF |
CSB-PA004957LB01HU | CD79A Antibody, HRP conjugated | Human | ELISA |
CSB-MA961575 | CD79A Monoclonal Antibody | Human | ELISA, IHC |
CSB-RA004957MA1HU | CD79A Recombinant Monoclonal Antibody | Human | ELISA |
CD79A Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-CF004957MO | Recombinant Mouse B-cell antigen receptor complex-associated protein alpha chain (Cd79a) | in vitro E.coli expression system |
CSB-YP004957MO1 CSB-EP004957MO1 CSB-BP004957MO1 CSB-MP004957MO1 CSB-EP004957MO1-B |
Recombinant Mouse B-cell antigen receptor complex-associated protein alpha chain (Cd79a), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD79A Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-CF004957BO | Recombinant Bovine B-cell antigen receptor complex-associated protein alpha chain (CD79A) | in vitro E.coli expression system |
CSB-YP004957BO1 CSB-EP004957BO1 CSB-BP004957BO1 CSB-MP004957BO1 CSB-EP004957BO1-B |
Recombinant Bovine B-cell antigen receptor complex-associated protein alpha chain (CD79A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CD79A Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-CF004957HU | Recombinant Human B-cell antigen receptor complex-associated protein alpha chain (CD79A) | in vitro E.coli expression system |
CSB-YP004957HU1 CSB-EP004957HU1 CSB-BP004957HU1 CSB-MP004957HU1 CSB-EP004957HU1-B |
Recombinant Human B-cell antigen receptor complex-associated protein alpha chain (CD79A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-MP004957HU1 | Recombinant Human B-cell antigen receptor complex-associated protein alpha chain (CD79A), partial (Active) | Mammalian cell |
CSB-MP004957HU1p6 | Recombinant Human B-cell antigen receptor complex-associated protein alpha chain (CD79A),Partial (Active) | Mammalian cell |
CD79A Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
Code | Product Name | Source |
---|---|---|
CSB-CF004957DO | Recombinant Dog B-cell antigen receptor complex-associated protein alpha chain (CD79A) | in vitro E.coli expression system |
CSB-YP004957DO1 CSB-EP004957DO1 CSB-BP004957DO1 CSB-MP004957DO1 CSB-EP004957DO1-B |
Recombinant Dog B-cell antigen receptor complex-associated protein alpha chain (CD79A), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |