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The production of the ERBB2 recombinant monoclonal antibody generally begins with the incorporation of the ERBB2 antibody-encoding gene into expression vectors. These vectors are then introduced into host cells using polyethyleneimine-mediated transfection. The host cells, housing the expression vectors, are cultured to manufacture and release the antibodies. Subsequent purification via affinity chromatography is followed by assessments through ELISA, verifying their ability to specifically bind to the human ERBB2 protein. In the functional ELISA, immobilized human ERBB2 protein (CSB-MP007763HU) at 2 μg/mL can bind this ERBB2 recombinant monoclonal antibody, with the EC50 of 2.455-3.565 ng/mL.
ERBB2 is a receptor tyrosine kinase that plays essential roles in cell growth, proliferation, survival, and differentiation. Dysregulation of ERBB2 signaling can contribute to cancer development, particularly in breast cancer, making it a significant therapeutic target in oncology.
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