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The phospho-ERBB2 (Y1139) recombinant monoclonal antibody is synthetically generated in vitro, starting with the extraction of ERBB2 antibody genes from B cells isolated from immunoreactive rabbits. These genes are then amplified and cloned into suitable phage vectors, which are subsequently introduced into mammalian cell lines to enable the production of functional antibodies in substantial quantities. Following this, the phospho-ERBB2 (Y1139) recombinant monoclonal antibody is purified from the culture supernatant of the transfected cell lines through affinity chromatography. It can used for the accurate detection of human ERBB2 protein phosphorylated at Y1139 in ELISA, IHC, and IF applications.
Phosphorylation of ERBB2 at Y1139 is a crucial post-translational modification that activates signaling pathways involved in cell growth, proliferation, and differentiation. Dysregulation of ERBB2 phosphorylation is implicated in cancer and is the target of therapeutic interventions in various malignancies, particularly breast cancer.
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