ERBB2 Research Reagents

Receptor tyrosine-protein kinase erbB-2 (also known as ERBB2) is a protein encoded by ERBB2 gene. The protein encoded by this gene is also known as epidermal growth factor receptor 2 (HER2) and is a member of the epidermal growth factor receptor family (EGFR). ERBB2 protein is a transmembrane glycoprotein with tyrosine kinase activity, which has a molecular weight of approximately 185 kDa, also known as p185. HER2 plays a crucial role in tissue development and is essential for normal embryonic development. Notably, HER2 is usually under- or non-expressed in normal adult body tissues. Over-expressed HER2 often causes biological dysfunction, and many studies have shown that HER2 expression is closely related to the occurrence of many tumors.

Currently, no ligand has been identified for ERBB2. HER2 can heterodimerise with any of the other three receptors (such as HER3 or HER4) and is also considered to be the preferred dimerisation partner of the other ERBB receptors. HER2 dimerization results in a conformational change that activates intracellular tyrosine kinase activity, thereby initiating a variety of signaling pathways mainly including RAS-RAF-MEK-ERK for cell proliferation and PI3K-AKT-mTOR pathway for cell survival.

Popular Product

Recombinant Human Receptor tyrosine-protein kinase erbB-2(ERBB2),partial (Active) (CSB-MP007763HU)

Validated Data

Purity determined
by SDS-PAGE

Greater than 95% as determined by SDS-PAGE.

The binding activity of antigen-antibody validated by functional ELISA

Immobilized HER2 at 2 μg/ml can bind Trastuzumab, the EC₅₀ is 2.179-2.825 ng/ml.