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This is a recombinant monoclonal antibody against MMP9. It is matched isotype control by rabbit IgG. The cloning of the human MMP9 DNA gene into the vector and subsequent transfection into the cell line for in vitro expression lead to the production of this MMP9 antibody. This MMP9 antibody shows reactivity with human MMP9 protein. It has been purified using affinity-chromatography and been tested for use in ELISA, IHC, and FC applications.
MMP9 mainly functions to degrade the extracellular matrix (ECM) in a wide spectrum of physiology and pathophysiology processes involving tissue remodeling. It also plays important roles in immune cell function. MMP9 deletion promotes the recruitment of eosinophils and Th2 cells into the lungs during allergen challenge. MMP9 upregulation has been found during development and wound healing in pathophysiological conditions, as well as during pathologies that involve inflammatory processes, including arthritis, diabetes, and cancer.
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