Code | CSB-RA011931A100phHU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
IHC | 1:50-1:200 |
IP | 1:200-1:1000 |
The rabbit IgG recombinant phospho-JAK2 (Y1007 + Y1008) monoclonal antibody specifically targets the human JAK2 phosphorylated at Tyr 1007 and Tyr 1008 residues. The DNA encoding the phospho-JAK2 (Y1007 + Y1008) monoclonal antibody was inserted into the plasmid and subsequently transfected into the cell line for expression. The product was purified through the affinity-chromatography method to get the phospho-JAK2 (Y1007 + Y1008) recombinant antibody. This phospho-JAK2 (Y1007 + Y1008) antibody shows reactivity with human samples. It has been validated for multiple applications, including ELISA, WB, IHC, and IP.
JAK2 is a non-receptor protein tyrosine kinase that belongs to the Janus kinase (JAKs) family, which also includes JAK1, JAK3, and TYK2. JAKs are cytoplasmic signaling components of cytokine receptors that are activated by cytokine-mediated trans-phosphorylation, which leads to receptor phosphorylation and recruitment and phosphorylation of STAT proteins. During cytokine stimulation, JAK2 is phosphorylated on multiple sites, including Tyr 1007 and Tyr 1008.
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