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| Code | CSB-CF006254HUa0 |
| Product Type | Transmembrane Protein |
| Size | Pls inquiry other sizes |
| Uniprot No. | P61073 |
| Relevance | Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.(Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes |
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| Storage Buffer | Tris-based buffer,50% glycerol |
| Species | Homo sapiens (Human) |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Sequence | MSIPLPLLQIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS |
| Source | in vitro E.coli expression system |
| Gene Names | CXCR4 |
| Protein Names | FB22FusinHM89LCR1Leukocyte-derived seven transmembrane domain receptor |
| Expression Region | 1-356aa |
| Tag Info | N-terminal 6xHis-tagged |
| Mol. Weight | 44.4kDa |
| Protein Description | Full length of Isofrm2 |
| Storage | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
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| Function | Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. |
| Involvement in disease | WHIM syndrome (WHIMS) |
| Subcellular Location | Cell membrane, Multi-pass membrane protein, Cell junction, Early endosome, Late endosome, Lysosome |
| Protein Families | G-protein coupled receptor 1 family |
| Tissue Specificity | Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microv |
| Database Links |
HGNC: 2561 OMIM: 162643 KEGG: hsa:7852 STRING: 9606.ENSP00000386884 UniGene: Hs.593413 |
| Pathway |
Chemokine signaling pathway
Leukocyte transendothelial migration Endocytosis |
CXCR4 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA006254GA01HU | CXCR4 Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA002588 | CXCR4 Antibody | Human,Mouse,Rat | WB,IF,ELISA |
| CSB-PA060127 | Phospho-CXCR4 (S339) Antibody | Human,Mouse,Rat,Monkey | WB,IHC,IF,ELISA |
| CSB-PA006254YD01HU | CXCR4 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA006254YC01HU | CXCR4 Antibody, FITC conjugated | Human | ELISA |
| CSB-PA006254YB01HU | CXCR4 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA263860 | CXCR4 Antibody | Human | ELISA,IHC |
| CSB-PA996565 | CXCR4 Antibody | Human | ELISA,IHC |
| CSB-PA250029 | CXCR4 Antibody | Human,Mouse,Rat | ELISA,IHC |
| CSB-PA099227 | CXCR4 Antibody | Human,Mouse,Rat | ELISA,IHC |
CXCR4 Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA006254YA01HU | CXCR4 Antibody | Human, Mouse | ELISA, WB, IHC, IF |
CXCR4 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-CF006254HU | Recombinant Human C-X-C chemokine receptor type 4(CXCR4) | in vitro E.coli expression system |
| CSB-EP006254HU1e0 | Recombinant Human C-X-C chemokine receptor type 4(CXCR4),partial | E.coli |
| CSB-EP006254HU1 | Recombinant Human C-X-C chemokine receptor type 4(CXCR4),partial | E.coli |
CXCR4 ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E12825h | Human CXC-chemokine receptor 4(CXCR4)ELISA Kit | serum, plasma, tissue homogenates | 3.9 pg/mL |
Recombinant Human Vascular cell adhesion protein 1(VCAM1),partial
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Human ATP synthase subunit delta, mitochondrial(ATP5D)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Proteasome subunit beta type-8(PSMB8)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Methionine aminopeptidase 2(METAP2)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Mouse Translationally-controlled tumor protein(Tpt1)
Express system: E.coli
Species: Mus musculus (Mouse)
Recombinant Mouse Ras-related protein Rab-10(Rab10)
Express system: E.coli
Species: Mus musculus (Mouse)
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