GFRAL: A Promising Metabolic Target for Improving Obesity and Anorexia/Cachexia
GFRAL: A Promising Metabolic Target for Improving Obesity and Anorexia/CachexiaGlobally, nearly 400 million people worldwide are obese and 19.3 million patients have been diagnosed of cancer, according to the statistics of World Health Organization. Each year, tens of thousands of people suffer fro...
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How to Properly Reconstitute Lyophilized Proteins?
How to Properly Reconstitute Lyophilized Proteins?In scientific research, proteins need to be added to the culture system or injected into the animal body in the form of a liquid with a certain concentration. However, many protein products are provided lyophilized to ...
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GCGR: A Regulator of Energy Balance Holds a Potential in Treatment Diabetes
GCGR: A Regulator of Energy Balance Holds a Potential in Treatment DiabetesWith the increase in the number of diagnosed diabetes, the diabetes drugs market is estimated to grow year by year. The new drugs design over diabetes treatment has soaked up more ink and excited more passion in recent y...
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Cross-reactivity of Antibody: Beneficial or Harmful?
Cross-reactivity of Antibody: Beneficial or Harmful?SARS-COV-2, which is ravaging around the world, has been the research hotspot since its breakout in late 2019. At the unremitting efforts of scientific researchers, several types of vaccines against SARS-COV-2 were suc...
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TNFRSF9: A Potent Immune-Stimulator in Cancer
TNFRSF9: A Potent Immune-Stimulator in CancerLast month, a study published on Nature Communications pointed that combining TNFRSF9 agonists with PD-L1 increases anti-tumor activity [1]. In recent years, TNFRSF9 has received much attention as a therapeutic target fo...
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The Overview of One Category of Important Cell Receptors: Receptor Tyrosine Kinases
The Overview of One Category of Important Cell Receptors: Receptor Tyrosine KinasesMulticellular organisms live in a complex milieu where signaling pathways play a key role in their survival. As important mediators of this signal cascade, tyrosine kinases exert critical effects in various biological ...
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An Overview of Cell Death: Necrosis and Apoptosis
An Overview of Cell Death: Necrosis and ApoptosisIn every human tissue, new cells are constantly being created while existing cells are constantly dying, so as to keep the total number of cells within the physiologically appropriate range. Cells in the human body hav...
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CD48: An Emerging Human Immune Co-stimulatory Molecule, Friend or Foe?
CD48: An Emerging Human Immune Co-stimulatory Molecule, Friend or Foe?On July 4, 2021, an article published in the journal Frontiers in immunology (IF: 7.561) entitled "Circulating and Tumor-Infiltrating NK Cells From Clear Cell Renal Cell Carcinoma Patients Exhibit a Predominantly Inhibit...
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NKG2D, a Powerful Molecule Involved In CAR-T And Car-NK Cell Therapy
NKG2D, a Powerful Molecule Involved In CAR-T And Car-NK Cell TherapyNKG2D, an activated receptor expressed on the surface of human natural killer cells (NKs), CD56+ and CD8+ T cells, plays an important role in innate immunity, participating in the recognition of virus-infected cells and ...
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DNA Damage and Repair
DNA Damage and RepairDNA is the repository of genetic information that is necessary for an organism to survive and reproduce, so maintaining the integrity of DNA molecules is crucial to cells. However, DNA is inevitably damaged during its co...
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