Multiple Myeloma, One of High-Risk Factors for COVID-19Accumulating studies have reported that among the people who face the greatest harm from COVID-19 (the disease caused by the SARS-CoV-2) are people with cancer [1]. And among those who have cancer, blood cancers like mul...
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STAT3: a Key Transcriptional Regulator in CancerSignal transducer and activator of transcription 3 (STAT3) is a latent cytoplasmic transcription factor [1]. It is interesting that STAT3 was discovered because of its role in the acute-phase response, which is the only ...
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Melanoma, the Most Serious Type of Skin CancerSkin cancer is the most common of all human cancers. In 2020, more than 100,000 people in the U.S. are expected to be diagnosed with some type of the disease. Nearly 7,000 are expected to die. There are three major types...
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Leukemia, Why is it So Common?Upon mentioned leukemia, marrow transplantation and anemia as keywords of leukemia come to your mind. Leukemia is the most common cancer in children and teens, accounting for almost 1 out of 3 cancers. Usually, the numbe...
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Bladder Cancer: Insights into Molecular Biology,Signaling Pathways, and BiomarkersBladder cancer is a prevalent malignant tumor, ranking fourth among cancers in men and commonly occurring in women, with men having a 3-4 times higher risk than women [1]. As of 2020, the American Cancer Society estimate...
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The Metabolic Phenotype of Tumor-Associated Macrophages in the Tumor MicroenvironmentIt is well-recognized that inflammation and immune escape are two hallmarks of tumors. Importantly, tumor-associated macrophages (TAMs), tumor-associated neutrophils (TANs), and bone marrow-derived suppressor cells (MDSC...
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Decoding the Biological Complexity of Endometrial Cancer: Essential Insights for ResearchersEndometrial cancer, a prevalent gynecological malignancy in women, has witnessed a rising incidence in recent years, garnering global medical attention. With evolving lifestyle and environmental factors, the pathogenesis...
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Osteoprotegerin (OPG): What is Its Potential as a Biomarker or Therapeutic Target?On July 22, 2020, a study published in the journal Cell Death & Differentiation reveals a new regulation mechanism in terms of the osteoprotegerin (OPG). The research implies for the first time that osteoprotegerin (...
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Streptococcus pneumoniae, a Primary Cause of PneumoniaStreptococcus pneumoniae (S. pneumoniae) is a major cause of pneumonia, meningitis, sepsis and other serious illnesses worldwide. In November 2010, the WHO announced that between 700,000 and 1 million children under the ...
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The Multifunctional Enzyme CD38: A Target for Immunotherapeutic Approaches in CancerRecently, CD38 causes fresh concerns in the field of anti-aging because two articles published in Nature Metabolis point that CD38 attributes to the NAD+ consumption [1-2]. NAD support is called by some as the "immortali...
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