NKG2D, a Powerful Molecule Involved In CAR-T And Car-NK Cell TherapyNKG2D, an activated receptor expressed on the surface of human natural killer cells (NKs), CD56+ and CD8+ T cells, plays an important role in innate immunity, participating in the recognition of virus-infected cells and ...
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DNA Damage and RepairDNA is the repository of genetic information that is necessary for an organism to survive and reproduce, so maintaining the integrity of DNA molecules is crucial to cells. However, DNA is inevitably damaged during its co...
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How to Choose? Polyclonal, Monoclonal, or Recombinant Antibody?With the rapid development of life science, researches on protein significantly mount, highlighting the prominent roles of antibodies in experiments. Facing the diverse and complex antibody reagent market, it is particul...
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Does LIF Only Play a Role in Leukaemia?Leukemia inhibitory factor (LIF) is a cytokine which belongs to the IL-6 superfamily. LIF derives its name from its ability to inhibit proliferation of myeloid leukemia cells in culture [1]. As the research of LIF progre...
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DLL3: A New Molecular Target in CancerOn October 24, 2024, Zai Lab, a biopharmaceutical company based in the U.S. and China, announced at the EORTC-NCI-AACR (ENA) meeting that its ZL-1310, an antibody-drug conjugate (ADC) targeting DLL3, demonstrated signifi...
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What Is Tomato Mosaic VirusTomato mosaic virus (ToMV), first reported in the United States in 1909, is a type of plant virus with worldwide distribution and can cause severe damage to various crops [1]. So exactly what is the tomato mosaic virus? ...
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Does Antibody-dependent Enhancement Occur in SARS-CoV-2 Infection?In 1964, Hawkes et al. demonstrated enhanced infectivity of viruses, including arboviruses, Murray Valley encephalitis virus, West Nile virus (WNV), Japanese encephalitis virus (JEV), and Getah viruses in the presence of...
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The Overview of Cell ViabilityCell-based assays are generic tools for measuring numerous biochemical or cellular functions. Bioassays can study various events including cell proliferation, morphology, migration, apoptosis, genetics, and signal tran...
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What Are Histones: Unraveling Their Critical Roles in Disease PathogenesisHistones are fundamental proteins that play a vital role in the packaging, organization, and regulation of DNA within the nucleus of eukaryotic cells. They form the building blocks of chromatin, the complex structure in ...
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Claudin 18.2, is a 'Dark Horse' in Anti-tumour Therapy?In May, 2020, the world's first CAR-T therapy targeting Claudin 18.2 was approved in the US; in June, 2020, the world's first Claudin 18.2/PD-L1 bispecific antibody preclinical data was presented at the AACR; and on July...
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