CADM1: an Immunoglobulin Superfamily Molecule, a New Tumor Suppressor Gene!CADM1 is a cell adhesion molecule that belongs to the immunoglobulin superfamily, and it has a ubiquitous presence in the human body. Apart from its abundance in multiple normal tissues where it serves various functions,...
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CD69: a Classical Early Marker of Lymphocyte Activation, a Pivotal Regulator of Hematologic Diseases and Autoimmune Disorders!A research paper entitled “HSF1 promotes CD69+Treg differentiation to inhibit colitis progression” was recently published in the journal Theranostics [1]. The study found that knockdown of CD69 induced autoimmune dis...
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DSG2: a Vital Member of Desmosomal Cadherin Family, an Exciting New Target for Cardiomyopathy, Adenovirus, and Tumors!DSG2 stands for desmoglein-2, which is a type of desmosomal cadherin protein. It is a well-established fact that mutations in a variety of desmogleins can lead to the development of cardiomyopathy, like Desmocollin-2, De...
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ULBP1: a Potent Member of NKG2D Ligands in CAR-T Therapy for Multiple Hematological and Solid Tumors!Lately, the world-leading haematology journal the Lancet Haematology published a report [1], suggesting that administering multiple infusions of CYAD-01 without preconditioning exhibited both favorable efficacy and safet...
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IL-17A: A Major Cytokine of the IL-17 Family, a Key Inflammation Target in Skin Diseases, or Inflammation-Associated Cancers!On March 25, 2023, China has achieved a significant milestone by successfully launching the first developed monoclonal antibody drug targeting IL-17A (Xeligekimab, GR1501). GR1501 is a human IL-17A-neutralizing IgG4 mono...
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Analysis of Factors Influencing ELISA DetectionELISA is a mature detection technology, which has been widely applied since its origin in the 19th century due to its unparalleled advantages. To achieve accurate, perfect, and reproducible experimental results, experime...
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Norwalk VirusNorwalk virus, also known as Norovirus, is a common intestinal virus that can cause acute gastroenteritis. In recent years, Norwalk virus has become one of the main pathogens causing human gastrointestinal diseases, espe...
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Cadherin-17 (CDH17): A Viable Target in Bispecific Antibodies or CAR-T Therapy to Fight Many Gastrointestinal Cancers!Recently, CDH17 has rapidly gained attention as a promising target for gastrointestinal cancers. In 2025, two significant BD transactions have drawn widespread interest: in October, Hansoh Pharma licensed the ex-Greater ...
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Exploring the Science of Influenza A Virus: What You Need to KnowThe winter and spring seasons every year mark the peak period of influenza A virus outbreaks. Due to its numerous hosts in the natural environment and its high potential for mutation or recombination, each outbreak can c...
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LY6G6D (LY6-G): A New Member of Lymphocyte Antigen-6 Family Holds Big Opportunities in Bispecific Antibody for CRC Treatment!Genentech, an innovative leader in large molecule pharmaceuticals, has developed a anti-LY6G6D/CD3 bispecific antibody (LY6G6D-TDB) for colorectal cancer (CRC) treatment in its earlier days. With an elaborately design, L...
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