CLDN3: Another Tight Junction Protein or New Drug Target, Interest in CLDN Family is Growing Fast!Now, as the Claudins continue to be explored, interest in emerging Claudins is growing fast! Claudins are the key constituent proteins of tight junction (TJ) proteins. TJ proteins play crucial roles of cell-cell adhesion...
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PROM1 (CD133): A New Cell Surface Marker of Cancer Stem Cells (CSCs), A More Significant Target for Immunotherapy!A study published in Science Translational Medicine recently made a big splash. The article entitled "Intracavity generation of glioma stem cell-specific CAR macrophages primes locoregional immunity for postoperative gli...
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TPBG/5T4: the Oncofetal Protein, an Appealing Target for ADC or Vaccine Therapeutics in Tumors!TPBG/5T4 has been so appealing recently to pharmaceutical companies as it yields encouraging results in tumor therapies. ClinicalTrial noted that there are over 10 TPBG-targeted drugs in clinical development. Notably, Ox...
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Categories over 10000! --Rare diseases that are no longer "Porcelain doll", "sticky baby" ... behind these seemingly beautiful words is the abyss of pain. It is reported that more than 350 million people in the world are suffering from rare diseases. Statistics show that the pr...
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Mucin-17/MUC17: An Unexpected Target for Tumor Immune Therapy, Notably Gastric Cancer!Lately, there is robust evidence that mucins play a crucial role in tumor formation, cell adhesion, immune response, and cell signaling. Typically, several mucins have become hot targets for tumor immunotherapy, such as ...
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VSIG4: a Prominent B7 Family Costimulatory Molecule or Complement Receptor in Cancers and Inflammatory Diseases!On November 28, 2022, Cancer Letters reported a review paper entitled "The biology of VSIG4: Implications for the treatment of immune-mediated inflammatory diseases and cancer", which describes the prominent roles of VSI...
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Epitope Tags OverviewIn 1984, S Munro and H R Pelham developed a technique to promote the purification and detection of recombinant proteins, in which an oligonucleotide encoding a peptide was fused to the protein of interest and the target ...
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GPCR Drugs DiscoveryAs the largest membrane protein family in the known human genome, G protein-coupled receptors (GPCRs) have glittered star proteins, which have been favored by pharmaceutical companies in recent years. GPCR is responsible...
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Monoclonal Antibody Drugs OverviewIn 1982, Humulin (human insulin), the world's first recombinant drug, was approved for marketing. This is a milestone in the development of drug access from chemical synthesis or extraction of Chinese medicine to biotech...
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SLC39A6/ZIP6: a Key Member of Zinc Transporters, a Novel Targeting Antigen of ADC!Presently, ADC competition heats up in global biotech or pharmaceuticals companies. According to the Pharmsnap database, there are nearly 100 partnered or licensed deals based on ADC new drugs, which has an estimated val...
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