Oncogenes and CancerIn fact, everyone has genes that possess the ability to cause cancer. These genes are known as proto-oncogenes, which are expressed to control normal cell processes such as proliferation, differentiation, and apoptosis. ...
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Protein Acetylation: An Important Post-translational Modification in Eukaryotic CellsAs is well-known, post-translational modifications (PTMs) are essential mechanisms for eukaryotic cells to diversify protein functions and dynamically coordinate signaling networks. Vincent Allfrey and colleagues first...
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A Group of Promising Proteins - Cell Cycle MarkersMost eukaryotic cells depends on an internal clock for survival; they proceed through a sequential event known as the cell cycle . The cell cycle allows multicellular organisms to grow and divide and single-celled orga...
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The Oncogene HER2: a New Target for Drug-Resistant TumorsOn March 17, 2021, a research paper entitled "Targeting transcription of MCL-1 sensitizes HER2-amplified breast cancers to HER2 inhibitors" [1] has attracted attention. Researchers found that the combination of MCL-1 inh...
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NRG1: an Intriguing Therapeutic Target in DiseasesOn January 7, 2021, the US FDA has granted a fast track designation to Zenocutuzumab (MCLA-128) as a potential therapeutic option for patients with metastatic solid tumors harboring NRG1 gene fusions. Early, Journal of T...
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TNFR1: A Multifaceted Molecule in Cancer, Another Promising Therapeutic Target for COVID-19On January 7, 2021, a study published in the journal Cancer Research showed that TNFR1-mediated apoptosis and necrosis are associated with leukemia [1]. TNFR1, as an emerging biological target, numerous studies confirm ...
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Neutralizing Antibody Stands Out Among Antiviral TherapiesHuman has been constantly struggling with various diseases from the birth. Human history documented several brutal, disastrous, and deadly diseases, such as smallpox, bubonic plague, cholera, and influenza. They broke ou...
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MUC16 (CA125): a Promising Predictive Marker and Therapeutic Target in CancerOn November 9, 2020, Quest PharmaTech Inc. announced that Oregovomab, a MUC16 monoclonal antibody, has been dosed in the patients with ovarian cancer in phase III clinical trial. It means that targeting MUC16 drugs will ...
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ERBB3/HER3: a New Target for Tumor Therapy, a Driver Gene of Multi-TumorsRecently, a study published in the journal Protein & Cell (impact factor: 10.164), attracted attention. The research found that ERBB3 mutation were closely related to tumor tolerance, and further revealed that anti-E...
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Non-Hodgkin's Lymphoma, One of Common Heterogeneous Malignant TumorsLymphoma is the most common of heterogeneous malignant tumors caused by malignant transformation of lymphocytes. Such tumors usually originate from the lymph nodes or other lymphatic tissues. From the 1970s to the 1990s,...
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