FLT4, known as vascular endothelial growth factor receptor 4 or VEGFR-3, is a receptor tyrosine kinase encoded by the FLT4 gene and predominantly expressed in lymphatic endothelial cells. FLT4 engages with its ligands VEGF-C and VEGF-D, initiating downstream PI3K/AKT and RAS/RAF/MEK/ERK signaling pathways that promote the proliferation and migration of lymphatic endothelial cells. This receptor plays a crucial role in the formation, development, and maintenance of lymphatic vessel function. Abnormal FLT4 expression is associated with diseases such as cancer, lymphedema, and acute myeloid leukemia, marking it as a potential target for drug development and treatment.
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
FLT4 Antibody (CSB-PA07539A0Rb)
Validated Data
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA07539A0Rb at dilution of 1:100
Immunofluorescent analysis of Hela cells using CSB-PA07539A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
The following FLT4 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
FLT4 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA008735GA01HU | FLT4 Antibody | Human | ELISA,WB |
CSB-PA277523 | FLT4 Antibody | Human | ELISA,WB,IHC,IF |
CSB-PA07539A0Rb | FLT4 Antibody | Human | ELISA, IHC, IF |
CSB-PA07539B0Rb | FLT4 Antibody, HRP conjugated | Human | ELISA |
CSB-PA07539C0Rb | FLT4 Antibody, FITC conjugated | Human | |
CSB-PA07539D0Rb | FLT4 Antibody, Biotin conjugated | Human | ELISA |
CSB-PA485851 | FLT4 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA156492 | FLT4 Antibody | Human,Mouse,Rat | IHC,ELISA |
FLT4 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA708790XA01DIL | flt4 Antibody | Danio rerio (Zebrafish) (Brachydanio rerio) | ELISA, WB (ensure identification of antigen) |
FLT4 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP008735MO CSB-EP008735MO CSB-BP008735MO CSB-MP008735MO CSB-EP008735MO-B |
Recombinant Mouse Vascular endothelial growth factor receptor 3 (Flt4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FLT4 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP008735HU CSB-EP008735HU CSB-BP008735HU CSB-MP008735HU CSB-EP008735HU-B |
Recombinant Human Vascular endothelial growth factor receptor 3 (FLT4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-MP008735HU-B | Recombinant Human Vascular endothelial growth factor receptor 3 (FLT4), partial,Biotinylated | Mammalian cell |
FLT4 Proteins for Coturnix coturnix (Common quail) (Tetrao coturnix)
Code | Product Name | Source |
---|---|---|
CSB-YP302922CRA CSB-EP302922CRA CSB-BP302922CRA CSB-MP302922CRA CSB-EP302922CRA-B |
Recombinant Coturnix coturnix Vascular endothelial growth factor receptor 3 (FLT4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FLT4 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
Code | Product Name | Source |
---|---|---|
CSB-YP708790DIL CSB-EP708790DIL CSB-BP708790DIL CSB-MP708790DIL CSB-EP708790DIL-B |
Recombinant Danio rerio Vascular endothelial growth factor receptor 3 (flt4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FLT4 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP846017RA CSB-EP846017RA CSB-BP846017RA CSB-MP846017RA CSB-EP846017RA-B |
Recombinant Rat Vascular endothelial growth factor receptor 3 (Flt4), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FLT4 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04765h | Human Vascuar endothelial cell growth factor receptor 3,VEGFR-3/Flt-4 ELISA Kit | serum, plasma, tissue homogenates | 0.039 ng/mL |
FLT4 ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04766m | Mouse Vascular endothelial cell growth factor receptor 3 (VEGFR-3/Flt-4) ELISA kit | serum, plasma, tissue homogenates | 19.5 pg/ml. |
FLT4 ELISA Kit for Rattus norvegicus (Rat)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E07336r | Rat FMS-like tyrosine kinase 3 ligand,Flt-3L ELISA Kit | serum, plasma,tissue homogenates | 3.9 pg/mL |