LTBR

LTBR, or Lymphotoxin beta receptor, also known as TNFCR, TNFR3, TNFR-RP, TNFRSF3, or LT-BETA-R, is a Type I single-transmembrane protein and a member of the tumor necrosis factor receptor superfamily. The primary ligands for LTBR include Lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14 (TNFSF14, also known as LIGHT).
LTBR plays a signaling role in the development of lymphoid and other organs, lipid metabolism, immune responses, and programmed cell death processes. Its activity is also associated with oncogenic effects. The LTBR signaling pathway is involved in activating responses that control cell differentiation, growth, and death, and is essential for the formation of peripheral lymphoid organs, particularly the development of secondary and tertiary lymphoid structures. LTBR signaling may promote communication between infiltrating immune cells and tumor cells, triggering LTβR can induce both canonical and non-canonical nuclear factor (NF)-κB signaling pathways, which are related to inflammation-induced oncogenesis.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
①Measured by its binding ability in a functional ELISA. Immobilized Human LTBR at 2 μg/ml can bind Anti-LTBR recombinant antibody (CSB-RA013227MA1HU), the EC₅₀ is 0.5282-0.6120 ng/mL.

Activity
②Measured by its binding ability in a functional ELISA. Immobilized Human LTBR at 2 μg/ml can bind human TNFSF14 (CSB-MP023991HUj7-B), the EC₅₀ is 7.283-8.859 ng/ml.

Recombinant Mouse Tumor necrosis factor receptor superfamily member 3 (Ltbr), Partial (Active) (CSB-MP013227MO)

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Mouse Ltbr at 2 μg/ml can bind human TNFSF14 (CSB-MP023991HUj7-B), the EC₅₀ is 15.43-18.78 ng/ml.

The purity of Ltbr was greater than 95% as determined by SEC-HPLC

Recombinant Macaca fascicularis Lymphotoxin beta receptor (LTBR), partial (Active) (CSB-MP6176MOV)

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus LTBR at 2 μg/ml can bind human TNFSF14 (CSB-MP023991HUj7-B), the EC₅₀ is 11.83-14.23 ng/ml.

LTBR Recombinant Monoclonal Antibody (CSB-RA013227MA1HU)

Validated Data

The Binding Activity of Human LTBR with Anti-LTBR Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human LTBR(CSB-MP013227HU1) at 2 μg/mL can bind Anti-LTBR recombinant antibody. The EC₅₀ is 0.6450-0.8200 ng/mL.

The Binding Activity of Human LTBR with Anti-LTBR Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human LTBR (CSB-YP013227HU1) at 2 μg/mL can bind Anti-LTBR recombinant antibody. The EC₅₀ is 0.5282-0.6120 ng/mL.

The following LTBR reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

LTBR Antibodies

LTBR Proteins

LTBR Antibodies

LTBR Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA013227GA01HU	LTBR Antibody	Human,Mouse	ELISA,WB,IHC
CSB-PA08129A0Rb	LTBR Antibody	Human	ELISA, IHC, IF
CSB-PA574901	LTBR Antibody	Human,Mouse	ELISA,WB,IF
CSB-PA003174	LTBR Antibody	Human,Mouse	WB, IF, ELISA
CSB-RA013227MA1HU	LTBR Recombinant Monoclonal Antibody	Human	ELISA

LTBR Proteins

LTBR Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-BP013227HU1 CSB-EP013227HU1-B	Recombinant Human Tumor necrosis factor receptor superfamily member 3 (LTBR), partial	Baculovirus In Vivo Biotinylation in E.coli
CSB-CF013227HU	Recombinant Human Tumor necrosis factor receptor superfamily member 3 (LTBR)	in vitro E.coli expression system
CSB-EP013227HU1	Recombinant Human Tumor necrosis factor receptor superfamily member 3 (LTBR), partial	E.coli
CSB-EP013227HU1a0	Recombinant Human Tumor necrosis factor receptor superfamily member 3 (LTBR), partial	E.coli
CSB-YP013227HU1	Recombinant Human Tumor necrosis factor receptor superfamily member 3 (LTBR), partial (Active)	Yeast
CSB-MP013227HU1	Recombinant Human Tumor necrosis factor receptor superfamily member 3 (LTBR), partial (Active)	Mammalian cell

LTBR Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP013227MO CSB-BP013227MO CSB-EP013227MO-B	Recombinant Mouse Tumor necrosis factor receptor superfamily member 3 (Ltbr), partial	Yeast Baculovirus In Vivo Biotinylation in E.coli

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LTBR

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