MAPK9

Mitogen-activated protein kinase 9 is a protein in humans that is encoded by MAPK9 gene. Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3.

MAPK9 Antibodies

MAPK9 Antibodies for Homo sapiens (Human)

MAPK9 Antibodies for Human

MAPK9 Proteins

MAPK9 Proteins for Gallus gallus (Chicken)

MAPK9 Proteins for Homo sapiens (Human)

MAPK9 Proteins for Rattus norvegicus (Rat)

MAPK9 Proteins for Mus musculus (Mouse)

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