PIK3R3 Research Reagents

Phosphatidylinositol 3-kinase regulatory subunit gamma is a protein in humans that is encoded by PIK3R3 gene. Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.

The following PIK3R3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

PIK3R3 Antibodies

PIK3R3 Antibodies for Homo sapiens (Human)

PIK3R3 Proteins

PIK3R3 Proteins for Bos taurus (Bovine)

PIK3R3 Proteins for Mus musculus (Mouse)

PIK3R3 Proteins for Rattus norvegicus (Rat)

PIK3R3 Proteins for Homo sapiens (Human)

PIK3R3 Background

Phosphatidylinositol 3-kinase regulatory subunit gamma is a protein in humans that is encoded by the PIK3R3 gene. PIK3R3 binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. Xi Yang et al. showed that the overexpression of PIK3R3 promoted hepatic fatty acid oxidation via PIK3R3-induced expression of PPARα, thus improving the fatty liver phenotype in high-fat diet (HFD)-induced mice [1]. By contrast, hepatic PIK3R3 knockout in normal mice led to increased hepatic TG levels. Our study also showed that PIK3R3-induced expression of PPARα was dependent on HNF4α. The novel PIK3R3-HNF4α-PPARα signaling axis plays a significant role in hepatic lipid metabolism. As the activation of PIK3R3 decreased hepatosteatosis, PIK3R3 can be considered a promising novel target for developing NAFLD and metabolic syndrome therapies.

[1] Xi Yang, Yinjia Fu, et al. PIK3R3 regulates PPARα expression to stimulate fatty acid β-oxidation and decrease hepatosteatosis [J]. Experimental & Molecular Medicine volume 50, pagee431(2018).

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