RUNX1, or Runt-related transcription factor 1, also known as AML1, CBFA2, or Runt-related transcription factor 1, is a transcription factor encoded by a gene located at the 21q22.3 position on human chromosomes and is a member of the RUNX transcription factor family. The mechanism of action of RUNX1 involves DNA binding and the formation of heterodimers, where the RUNX1 protein contains a Runt homology domain (RHD) that mediates the formation of heterodimers with CBFβ and promotes DNA binding, thereby regulating the expression of multiple genes.
RUNX1 is crucial for maintaining normal hematopoiesis and is involved in various biological processes such as cell differentiation, proliferation, cell cycle, DNA repair, and apoptosis. Mutations in the RUNX1 gene can be found in various hematological tumors, particularly at a higher frequency in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), and they indicate a poor prognosis for patients. Abnormal expression or loss of function of RUNX1 is associated with the development and progression of tumors, making it one of the key molecules in the study of myeloid tumors.
Recombinant Human Runt-related transcription factor 1 (Runx1) (CSB-EP020592HU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Validated Data
Western blot analysis of extract from P19, Hela and 293 cells using AML1(RUNX1) Antibody
The following RUNX1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
RUNX1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA020592GA01HU | RUNX1 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA245126 | RUNX1 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA570589 | Phospho-RUNX1 (Ser276) Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA126379 | Phospho-RUNX1 (Ser303) Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA110286 | Phospho-RUNX1 (Ser435) Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA132524 | RUNX1 (Ab-435) Antibody | Human,Mouse | ELISA,WB |
CSB-PA070101 | Phospho-RUNX1 (S249) Antibody | Human,Mouse,Rat | WB, ELISA |
CSB-PA070102 | Phospho-RUNX1 (S435) Antibody | Human,Mouse,Rat | WB, ELISA |
CSB-PA070103 | Phospho-RUNX1 (S276) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA070104 | RUNX1 Antibody | Human,Mouse,Rat | WB, ELISA |
CSB-PA070106 | RUNX1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA010571 | RUNX1 Antibody | Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA161481 | RUNX1 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA020592LD01HU | RUNX1 Antibody, Biotin conjugated | Human | ELISA |
CSB-PA020592LC01HU | RUNX1 Antibody, FITC conjugated | Human | |
CSB-PA020592LB01HU | RUNX1 Antibody, HRP conjugated | Human | ELISA |
CSB-PA020592LA01HU | RUNX1 Antibody | Human | ELISA, WB, IF |
RUNX1 Antibodies for Rattus norvegicus (Rat)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA020592ZA01RA | Runx1 Antibody | Rattus norvegicus | ELISA, WB (ensure identification of antigen) |
RUNX1 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP020592RA CSB-MP020592RA CSB-EP020592RA-B |
Recombinant Rat Runt-related transcription factor 1 (Runx1) | Yeast Mammalian cell In Vivo Biotinylation in E.coli |
CSB-BP020592RA | Recombinant Rat Runt-related transcription factor 1 (Runx1) | Baculovirus |
CSB-EP020592RA | Recombinant Rat Runt-related transcription factor 1 (Runx1) | E.coli |
RUNX1 Proteins for Xenopus laevis (African clawed frog)
Code | Product Name | Source |
---|---|---|
CSB-YP020592XBE CSB-EP020592XBE CSB-BP020592XBE CSB-MP020592XBE CSB-EP020592XBE-B |
Recombinant Xenopus laevis Runt-related transcription factor 1 (runx1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RUNX1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-EP020592HUb1 | Recombinant Human Runt-related transcription factor 1 (Runx1) | E.coli |
CSB-EP020592HU | Recombinant Human Runt-related transcription factor 1 (Runx1) | E.coli |