arsD

ARSD, the protein associated with argininosuccinate synthetase deficiency, serves as a crucial enzyme in the urea cycle. Its structural features, including specific catalytic centers and regulatory domains, enable it to efficiently catalyze the synthesis of argininosuccinate from arginine and succinate. Functionally, ARSD plays a pivotal role in the ammonia detoxification pathway of the urea cycle, maintaining ammonia balance in the body, which is crucial for preventing ammonia intoxication and preserving normal neural function. Although ARSD does not directly participate in signal transduction, its functional defects can lead to urea cycle disorders, triggering biochemical reactions and signal changes that affect cellular function and body homeostasis. Therefore, in-depth research on the structure, function, and signaling pathways of ARSD is crucial for understanding the regulatory mechanisms of the urea cycle and diagnosing and treating related diseases.

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Recombinant Human Arylsulfatase D (ARSD)