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| Code | CSB-CL878863HU1 |
| Size | 10 μg plasmid + 200μl Glycerol |
| Uniprot No. | Q9NR81 |
| Relevance | Homo sapiens Rho guanine nucleotide exchange factor (GEF) 3 (ARHGEF3), transcript variant 1, mRNA. |
| Alias | GEF3; STA3; XPLN |
| Immunogen Species | Homo sapiens (Human) |
| Vector | pUC |
| Sequence | atggacagttccacagcaat gaatcaatgc agctgtagag gaatggaaga aaacaaggaa aggcctaaacggcagcggca aaacaacttt cccatgtttc cctctcctaa agcctggaat ttcagagggcgaaaacggaa acagagcacc caagatgaag atgctgttag cctttgcagt ctcgacataagtgagcctag taataaacgg gtcaaacccc tttcccgagt cacgtcgcta gcaaacctcatcccgcccgt gaaggccacg ccattaaagc gcttcagtca aaccctgcag cgctccattagcttccgcag tgagagccgc cctgacatcc tcgccccccg accctggtcc agaaatgccgccccctcgag cacgaaacgg agagatagca agctgtggag tgagaccttc gatgtgtgcgtcaatcagat gcttacatcc aaggaaatca aacgtcagga ggcgatcttt gagctttcccaaggagaaga agacttgata gaagacttga aattagcaaa aaaggcctat catgaccccatgctgaaact ctccataatg acagaacaag agttgaatca aatttttgga acactggactctctaattcc tctacatgaa gagctcctta gtcagcttcg agatgttagg aagcctgatggctcgactga acatgttggt cccatcctcg tgggctggct cccttgcctc agctcctatgatagctactg cagcaatcaa gtagccgcca aagctctgct ggaccacaaa aagcaagatcaccgagtcca ggatttccta cagcgatgtt tagaatcccc ctttagccgc aaactagatctctggaattt cctcgatatt ccaagaagcc gcctggtaaa ataccctctg cttctccgagaaatcttgag gcacacacca aatgataatc cagatcagca gcacttggaa gaagctataaatatcattca gggaattgtg gcagaaatca acaccaagac tggtgaatct gaatgccgctattataaaga gcggcttctt tacttggaag aaggccagaa agactccctg atcgacagctctcgagtctt gtgttgtcat ggtgaactga agaacaatcg gggcgtgaaa ctgcatgttttcctgttcca agaagtgctt gtgatcactc gagccgtcac ccacaatgag cagctttgctaccagctgta ccgtcagcca atccccgtga aagacctcct gctggaagac ctccaggatggagaagtgag gctgggtggc tccctgcgag gggcattcag caacaatgag agaattaaaaacttcttcag agtcagtttc aaaaatggat cccaaagtca gacccactcg ctacaagccaatgacacttt caacaaacag cagtggctta actgtattcg tcaagccaaa gaaacagttttgtgtgctgc cgggcaagct ggggtgcttg actccgaggg atcgttccta aatcccaccaccgggagcag agagctacag ggagaaacaa aacttgagca gatggaccaa tcggacagtgagtcagactg tagtatggac acgagtgagg tcagcctcga ctgtgagcgc atggaacagacagactcttc ctgtggaaac agcaggcacg gtgaaagtaa cgtctga |
| Gene Names | ARHGEF3 |
| Accession NO. | NM_001128615.1 |
| Target Details | Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| HGNC | 683 |
| RGD | 1310672 |
| MGI | 1918954 |
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| Function | Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Widely expressed. Highest levels are found in adult brain and skeletal muscle. Lower levels are found in heart and kidney. |
| Database Links |
HGNC: 683 OMIM: 612115 KEGG: hsa:50650 STRING: 9606.ENSP00000341071 UniGene: Hs.476402 |
ARHGEF3 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA878863ESR1HU | ARHGEF3 Antibody | Human | ELISA, IHC |
| CSB-PA878863ESR2HU | ARHGEF3 Antibody | Human | ELISA, WB, IHC |
| CSB-PA004526 | ARHGEF3 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA238135 | ARHGEF3 Antibody | Human,Mouse | ELISA,IHC |
ARHGEF3 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP878863HU CSB-EP878863HU CSB-BP878863HU CSB-MP878863HU CSB-EP878863HU-B |
Recombinant Human Rho guanine nucleotide exchange factor 3 (ARHGEF3) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ARHGEF3 cDNA for Homo sapiens (Human)
| Code | Product Name | Vector | Accession NO. |
|---|---|---|---|
| CSB-CL878863HU2 | ARHGEF3 | pUC | NM_001128616.1 |
