Recombinant Mouse Macrophage colony-stimulating factor 1 protein (Csf1), partial (Active)

1. In glioblastoma, colony-stimulating factor-1 and angiocrine IL-6 induce robust arginase-1 expression and macrophage alternative activation, mediated through peroxisome proliferator-activated receptor-gamma-dependent transcriptional activation of hypoxia-inducible factor-2alpha. PMID: 29422647
2. M-CSF serves as an intermediate signal, thus inducing a vital decrease in the NPR2 levels in cumulus cells, and regulates the process of LH-induced resumption of meiosis. PMID: 28978329
3. Findings revealed that stress-induced elevations in neuronal CSF1 provokes microglia-mediated neuronal remodeling in layer 1 medial prefrontal cortex, contributing to synaptic deficits and development of anxiety- and depressive-like behavior. Moreover, chronic stress exposure elicited divergent neuroimmune responses in male and female mice, demonstrating sex-dependent differences in neuron-microglia interactions. PMID: 28697890
4. PLEKHO2-deficient bone marrow-derived macrophages displayed increased apoptotic cell death in the absence of Macrophage-colony stimulating factor, although PLEKHO2 deficiency did not affect macrophage differentiation and proliferation. PMID: 28627369
5. lymphatic endothelial cells cause bone destruction in vivo in mice by secreting M-CSF, which promotes osteoclasts formation and activation. PMID: 28052488
6. address which CSF-1-activated pathways are involved in transmitting the lineage-instructive signal in primary bone marrow-derived GM progenitors. PMID: 28159742
7. study concludes that M-CSF is critical to host defenses against bacterial pneumonia by mediating survival and antimicrobial functions of mononuclear phagocytes in the lungs and liver. PMID: 27183631
8. study, therefore, provided insights into the sequence-structure-function relationships of the M-CSF/c-FMS interaction and of ligand/receptor tyrosine kinase interactions in general. PMID: 28655719
9. Therefore, our findings indicate that CSF1 signaling is oncogenic during gliomagenesis through a mechanism distinct from modulating glioma-associated microglia/macrophage polarization status PMID: 27013192
10. study concludes that Langerhans cells require IL-34 when residing in fully differentiated and anatomically intact skin epidermis, but rely on neutrophil-derived CSF1 during inflamma PMID: 26634935
11. Proteomic Analysis Reveals Distinct Metabolic Differences Between Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) and Macrophage Colony Stimulating Factor (M-CSF) Grown Macrophages Derived from Murine Bone Marrow Cells PMID: 26229149
12. Hematopoietic cells can be induced by M-CSF to dedifferentiate to multipotent stem cells. PMID: 26529564
13. M-CSF promotes macrophagic over granulocytic differentiation by inducing ERK activation but also PKCd expression, which in turn, down-regulates Fli-1 expression and prevents granulocytic differentiation. PMID: 26336156
14. Results identify CSF-1-activated macrophages as crucial mediators of detrimental Schwann cell dedifferentiation in Cx32-deficient mice PMID: 25628221
15. Ceramide production in M-CSF-deprived macrophages arises from a combination of ASMase activity and de novo synthesis. PMID: 26253821
16. CSF-1 did not rescue the growth and lung defects associated with hyperoxia in this model; however, an increase in CSF-1R+ macrophages was not associated with an exacerbation of lung injury. PMID: 25192716
17. CSF-1 neutralization led to a relatively uniform reduction in all inflammatory cell populations; GM-CSF neutralization resulted in the preferential loss among the monocyte/macrophage populations. PMID: 26019271
18. The results of this study indicated that the CSF1 overexpression observed in CNS pathologies likely has pleiotropic influences on microglia. PMID: 25042473
19. FoxO1 is highly expressed in M-CSF-derived (M2-like) macrophage subsets, and this M2-like macrophages showed a preferential FoxO1 enrichment on the IL-10 promoter but not in GM-CSF-derived (M1-like) macrophages PMID: 25420919
20. CSF-1 has a role in macrophage mediation of chronic graft-versus-host disease PMID: 25157821
21. tumor cells TACE-shed MCSF promotes angiogenesis through activation of the NF-kappaB pathway in macrophages and the subsequent release of VEGF. PMID: 24197832
22. these findings reveal a role for CSF-1 in mediating the IL-3 hematopoietic pathway through monopoiesis, which regulates expansion of CD11c+ macrophages. PMID: 24743235
23. Tbx3 plays an important role in osteoclastogenesis at least in part by regulating CSF1-dependent expression of JDP2. PMID: 24394418
24. in lung cancer bone metastasis, regulates tumor cell proliferation, cancer stem-like cells, and osteoclastic bone resorption PMID: 24468794
25. data may explain the association of the P72 variant and the CSF1/CSF1R pathway with increased senescence and radio-resistance in some epithelial tumor types PMID: 24019961
26. Pulsed ultrasound enhanced autocrine secretion of macrophage colony-stimulating factor (M-CSF), which subsequently activated the focal adhesion kinase (FAK) pathway to promote melanoblast migration. PMID: 23725022
27. The IL-4 pathway of proliferation may have developed as an alternative to CSF-1 to increase resident macrophage numbers without coincident monocyte recruitment. PMID: 24101381
28. the feline CSF-1R was cloned and the responsiveness to CSF-1 and IL-34 from a range of species, was examined. PMID: 23260168
29. Differentiated signaling between IL-34 and CSF-1 is likely achieved by the relative thermodynamic independence of IL-34 versus negative cooperativity of CSF-1 at the CSF-1 receptor recognition sites. PMID: 22579672
30. Identify donor/recipient cell surface colony stimulating factor-1 signaling as promoter of neointimal formation in transplant-associated arteriosclerosis. PMID: 23117661
31. CSF-1-mediated expansion and polarization of resident renal macrophages/dendritic cells is an important mechanism mediating renal tubule epithelial regeneration after acute kidney injury. PMID: 23143303
32. Data suggest that membrane-bound CSF1 is not required for estrogen-deficiency bone loss; in contrast, soluble CSF1 isoform could play a key role in this pathologic process. PMID: 22105655
33. Study results provide a mechanistic explanation for the involvement of CSF-1 in glioblastoma progression and indicate that inhibition of CSF-1R signaling could provide a novel approach to limiting glioblastoma invasion PMID: 22294205
34. Postnatal neocortical expression showed that CSF-1 was expressed in layer VI, whereas IL-34 was expressed in the meninges and layers II-V. PMID: 22542597
35. CSF-1 deficiency decreased macrophage infiltration by approximately 50% during all stages of RT2 tumor progression. PMID: 21822305
36. Results point to a novel link between CSF-1 and osteocyte survival/function that is essential for maintaining bone mass and strength during skeletal development. PMID: 21958845
37. Intrarenal expression of csCSF-1 and spCSF-1 increases with advancing nephritis, thereby promoting the intrarenal recruitment of monocytes and expansion of Ly6C(hi) macrophages, which induce apoptosis of the renal parenchyma. PMID: 21885670
38. Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1. PMID: 21825019
39. Matured macrophages by M-CSF play pivotal role by scavenging endotoxin in inflammation. PMID: 20189586
40. Splenic CSF-1-dependent F4/80-(highly expressed) Mac-1-(low expressing) macrophages (MPhis) are a subpopulation of red pulp MPhis that regulate peripheral immune homeostasis. PMID: 21239712
41. Granulocyte colony-stimulating factor enhances collateral artery growth and reduces infarct volume in a mouse model of brain ischemia, similarly to granulocyte-macrophage colony-stumulating factor (GM-CSF). PMID: 21257824
42. M-CSF-induced hepatic macrophages play an important role in liver regeneration after partial hepatectomy. PMID: 20031174
43. Data suggest that the CSF-1 pathway contributes to monocyte recruitment and macrophage survival and that this pathway is a potential target for therapeutic intervention. PMID: 20194110
44. The different spatiotemporal expression of IL-34 and CSF-1 allows for complementary activation of the CSF-1R in developing and adult tissues. PMID: 20504948
45. Transcriptional effects of colony-stimulating factor-1 in mouse macrophages. PMID: 19758725
46. Compressive force induces osteoclast differentiation by increasing M-CSF production and decreasing OPG production via PGE(2) in osteoblasts. PMID: 20001844
47. Genomic DNA from SB-induced astrocytoma tissue was extracted and transposon insertion sites were identified. Insertions in the growth factor gene Csf1 were found in 13 of the 21 tumors. PMID: 20388773
48. macrophage-colony-stimulating factor activates Src family kinases and Cbl proteins, and subsequently, induces NFATc1 degradation during osteoclast differentiation. PMID: 20037154
49. Studies demonstrated that increased CSF-1 production by host cells enhances TAM recruitment and NB growth. PMID: 19711348
50. Colony-stimulating factor 1 has a role in establishing early endometriotic lesions. PMID: 18990370

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KEGG: mmu:12977

STRING: 10090.ENSMUSP00000014743

UniGene: Mm.795