Mouse ADP-ribosyl cyclase 1(CD38) ELISA kit

Instructions
Code CSB-EL004929MO
Size 96T,5×96T,10×96T
Trial Size 24T ELISA kits trial application
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Product Details

Target Name CD38 molecule
Alternative Names Cd38ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 ELISA Kit; EC 3.2.2.6 ELISA Kit; 2'-phospho-ADP-ribosyl cyclase ELISA Kit; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase ELISA Kit; EC 2.4.99.20 ELISA Kit; 2'-phospho-cyclic-ADP-ribose transferase ELISA Kit; ADP-ribosyl cyclase 1 ELISA Kit; ADPRC 1 ELISA Kit; Cyclic ADP-ribose hydrolase 1 ELISA Kit; cADPr hydrolase 1 ELISA Kit; I-19 ELISA Kit; NIM-R5 antigen ELISA Kit; CD antigen CD38 ELISA Kit
Abbreviation CD38
Uniprot No. P56528
Species Mus musculus (Mouse)
Sample Types serum, plasma, tissue homogenates
Detection Range 0.625 ng/mL-40 ng/mL
Sensitivity 0.156 ng/mL
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Immunology
Assay Principle quantitative
Measurement Sandwich
Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 7-14 working days

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Target Data

Function Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity (By similarity).
Gene References into Functions
  1. Pathological and morphological screening of CD38-/- mouse brains reveals the involvement of CD38 in the development of the primary visual cortex and the hippocampus. Results show that the neuron count in the primary visual cortex and the dentate gyrus was significantly decreased, and pyramidal neurons in the visual cortex and hippocampus have an abnormal morphology. PMID: 29306053
  2. our data are consistent with the conclusion that CD38 plays a role in murine and human lung tumorigenesis PMID: 29228209
  3. CD38 deficiency significantly protected hearts from lipid-induced injury via regulating redox homeostasis, lipid metabolism and apoptosis in myocardial cells through activating Sirt3/FOXO3 signaling pathway. PMID: 30114710
  4. these findings demonstrated a role of CD38 signaling pathway on the airway hyperresponsiveness of obesity PMID: 29414651
  5. data demonstrate that CD38 represents a new marker that identifies committed preadipocytes as CD45(-) CD31(-) CD34(low) CD38(+) cells PMID: 28611394
  6. Blockade of CD38 diminishes lipopolysaccharide-induced macrophage classical activation and acute kidney injury involving NF-kappaB signaling suppression. PMID: 29080804
  7. the results presented in this study suggest that CD38 deficiency induces features of autoimmune disorders in aged mice and that CD38 could play a role in the control of autoimmune diseases through their expression on regulatory B cells. PMID: 29603313
  8. CD38 plays an essential role in cardiac hypertrophy probably via inhibition of SIRT3 expression and activation of Ca(2+) -NFAT signaling pathway. PMID: 28296029
  9. Determined the role of CD38, an enzyme involved in cellular calcium modulation and autophagic flux, in the regulation of collagen I degradation in coronary arterial myocytes (CAMs).In primary cultured CAMs from CD38(-/-) mice, collagen I protein accumulation but not mRNA abundance was significantly increased compared with cells from CD38(+/+) mice. PMID: 27814632
  10. Data, including data from studies on cells from knockout mice, suggest that intracellular CD38 contributes to NAADP production and cADPR production in cardiomyocytes; membrane fractions from wildtype but not CD38-/- mouse hearts support NAADP and cADPR synthesis; CD38 may be associated with sarcoplasmic reticulum of cardiomyocytes. (NAADP = nicotinate adenine dinucleotide phosphate; cADPR = cyclic ADP-ribose) PMID: 28539361
  11. These data provide the first experimental evidence that the proper function of CD38/nicotinic acid adenine dinucleotide phosphate pathway plays an essential role in promoting free cholesterol efflux. PMID: 26818887
  12. expression and activity of the NADase CD38 increase with aging and that CD38 is required for the age-related NAD decline and mitochondrial dysfunction via a pathway mediated at least in part by regulation of SIRT3 activity. PMID: 27304511
  13. Study found that deletion of CD38 caused impaired astrocytic and oligodendrocytic development in the cortex, probably by increasing NAD+ levels and decreasing Cx43 expression levels. PMID: 28295574
  14. These results suggested that CD38 may be involved in the DC function of alleviating asthma via restoration of the Th1/Th2 balance, thus providing a novel strategy for asthma therapy. PMID: 27666020
  15. CD38 deficiency protects the heart from ischemia/reperfusion injury through activating SIRT1/FOXOs-mediated antioxidative stress pathway. PMID: 27547294
  16. Identification of multiple transferrin species in the spleen and serum from mice with collagen-induced arthritis which may reflect changes in transferrin glycosylation associated with disease activity: The role of CD38. PMID: 26639305
  17. CD38 is critical for regulating hippocampus-dependent learning and memory without modulating synaptic plasticity. PMID: 26856703
  18. CD38 signaling pathway is required for neuronal differentiation of embryonic stem cells by modulating reactive oxygen species production. PMID: 26012865
  19. CD38/cADPR-mediated Ca(2+) signals play a key role in glucagon-induced gluconeogenesis in hepatocytes, and that the signal pathway has significant clinical implications in metabolic diseases, including type 2 diabetes. PMID: 26038839
  20. CD38 is expressed in MDSCs in mouse models of esophageal carcinogenesis. CD38(high) MDSCs are immature, suggesting a potential role for CD38 in the maturation halt found in MDSC populations. IL6, IGFBP3, and CXCL16 induce CD38 expression by MDSCs ex vivo. PMID: 26294209
  21. CD38 activation after NADPH depletion triggers endothelial dysfunction in the postischemic heart PMID: 26297248
  22. In a model of Alzheimer disease, CD38 deficient mice had decreased amyloid-beta plaque burden, decreased microglia/macrophage accumulation, and better spatial learning. PMID: 25893674
  23. sCD38 released from seminal vesicles to the seminal plasma acts as an immunoregulatory factor to protect semiallogeneic fetuses from maternal immune responses PMID: 25591581
  24. These data demonstrate that B-cell precursors in mouse bone marrow express functional CD38 and implicate the early ligation of CD38 in the ERK-associated regulation of the B-lineage differentiation pathway. PMID: 25155483
  25. Data show that CD38 knockout mice presented significant increases of cytokine mRNA expression, as well as liver damage after lipopolysaccharide (LPS)/D-galactosamine (D-GalN)-induced acute hepatic injury. PMID: 25270198
  26. CD38 mediates microglial function and survival by mediating ATP release from microglia. PMID: 24578339
  27. CD38 plays a critical role in autophagosome trafficking and fusion with lysosomes PMID: 24445604
  28. CD38 in the nucleus accumbens and oxytocin are critical in paternal behavior. PMID: 24059452
  29. Renal vasoconstriction by vasopressin V1a receptors is modulated by nitric oxide, prostanoids, and superoxide but not the ADP ribosyl cyclase CD38. PMID: 24623148
  30. CD38 importantly control lysosomal function and influence autophagy at the maturation step in podocytes. PMID: 24238063
  31. results suggest that SNPs in CD38 may be possible risk factors for autism spectrum disorders (ASD) by abrogating oxytocin (OXT) function and that some ASD subjects can be treated with OXT in preliminary clinical trials PMID: 22366648
  32. The CD38/cADPR signaling pathway may be one underlying mechanism of the glucose and insulin effects of the alpha-2 adrenergic receptor agonist medetomidine and likely other drugs of its class. PMID: 23565906
  33. NOX1-dependent superoxide production mediates CD38 internalization in coronary arterial myocytes. PMID: 23940720
  34. In conclusion, these results demonstrate an essential role for CD38 in the innate immune response against Listeria monocytogenes. PMID: 23980105
  35. CD38-cADPR mediates bile acid-induced pancreatitis and acinar cell injury through aberrant intracellular Ca(2+) signaling. PMID: 23940051
  36. PECAM1(+)/Sca1(+)/CD38(+) vascular cells could proliferate and differentiate into myofibroblast-like cells in wound repair. PMID: 23308177
  37. These results show that CD38 is a novel pharmacological target to treat metabolic diseases via NAD(+)-dependent pathways. PMID: 23172919
  38. The tetrameric interaction underlies the multifaceted actions of CD38. PMID: 22863568
  39. the CD38-cADPR-Ca(2+) signaling pathway antagonizes the CM differentiation of mouse ES cells. PMID: 22908234
  40. The normal expression of CD38 importantly contributes to the differentiation and function of podocytes. PMID: 21992601
  41. Our results thus suggest that CD38 participates in the tumor-supporting action of glioma-infiltrating microglia and macrophages PMID: 22700727
  42. CD38 participates in the pathogenesis of collagen-induced arthritis controlling the number of iNKT cells and promoting Th1 inflammatory responses. PMID: 22438945
  43. a crucial role of CD38 in FcgammaR-mediated phagocytosis through its recruitment to the phagosome and mobilization of cADPR-induced intracellular Ca(2+) and store-operated extracellular Ca(2+) influx. PMID: 22396532
  44. we review the functional roles of cyclic ADP-ribose and CD38, a transmembrane protein with ADP-ribosyl cyclase activity, in mouse social behavior via the regulation of oxytocin (OXT) release--REVIEW PMID: 22227279
  45. direct evidence that the CD38 cyclic ADP ribose pathway is an important controller of Nox4-mediated intracellular superoxide production PMID: 22100343
  46. CD38 plays a critical role in the basal survival of microglia, and decreased CD38 can lead to caspase 3-dependent apoptosis of the cells. PMID: 22293203
  47. CD38 contributes to behavioral and metabolic circadian rhythms and altered NAD(+) levels influence the circadian clock. PMID: 21937766
  48. In conclusion, CD38 is important for neutrophils migration during hepatic amoebiasis, and in turn, these cells play an important role in the innate immune response. PMID: 21919917
  49. In vivo CD38 appears to be a NAADP degrading rather than a NAADP forming enzyme PMID: 22020217
  50. The myocardial contractility, contraction and relaxation velocities were significantly enhanced only in male CD38-null mice, in which the levels of serum testosterone were markedly elevated. PMID: 21840325

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Subcellular Location Membrane, Single-pass type II membrane protein
Protein Families ADP-ribosyl cyclase family
Database Links

KEGG: mmu:12494

STRING: 10090.ENSMUSP00000030964

UniGene: Mm.249873

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