Mouse hepatocyte growth factor,HGF ELISA kit

Instructions
Code CSB-E07347m
Size 96T,5×96T,10×96T
See More Details 24T ELISA kits trial application
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Product Details

Target Name hepatocyte growth factor (hepapoietin A; scatter factor)
Alternative Names Hgf ELISA Kit; Hepatocyte growth factor ELISA Kit; Hepatopoietin-A ELISA Kit; Scatter factor ELISA Kit; SF) [Cleaved into: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain] ELISA Kit
Abbreviation HGF
Uniprot No. Q08048
Species Mus musculus (Mouse)
Sample Types
Detection Range
Sensitivity
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Cancer
Assay Principle quantitative
Measurement Sandwich
Precision   

Linearity  
  

Recovery   
Typical Data    

Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 3-5 working days

Target Data

Function Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.
Gene References into Functions
  1. CBD-HGF combined with hydrogel scaffold may be promising for the treatment of serious SCI. PMID: 29343699
  2. these results suggested that HGF may exert beneficial effects on type II diabetesinduced chronic renal failure via regulation of the NFkappaB signaling pathway. PMID: 30066918
  3. HGF is beneficial for bone regeneration via increased expression of BMP-2, which leads to neovascularization and bone regeneration through regulation of the NF-kappaB signaling pathway. PMID: 29436622
  4. these findings highlight the relevance of cross-species protein interactions between murine feeder cells and human epithelial cells in 3T3-J2 co-culture and demonstrate that STAT6 phosphorylation occurs in response to MET activation in epithelial cells. However, STAT6 nuclear translocation does not occur in response to HGF, precluding the transcriptional activity of STAT6. PMID: 29771943
  5. prolonged treatment of single HGF/c-Met or Hh inhibitor leads to resistance to these single inhibitors, likely because the single c-Met treatment leads to enhanced expression of Shh, and vice versa. Targeting both the HGF/c-Met and Hh pathways simultaneously overcame the resistance to the single-inhibitor treatment and led to a more potent antitumor effect in combination with the chemotherapy treatment. PMID: 28864680
  6. These results indicate that expression and production of HGF are regulated in a species-specific adipogenic differentiation-dependent manner and suggest that the decrease in HGF mRNA in mouse differentiated adipocytes is, at least in part, mediated by differentiation-dependent loss of its stability. PMID: 29040876
  7. Mesenchymal stem cells microvesicles stabilization of endothelial barrier function is partly mediated by hepatocyte growth factor. PMID: 28969681
  8. Study used biochemical and morphological analyses to demonstrate that two discrete intracellular signaling pathways underlie distinct HGF-induced biological outcomes in developing neocortical neurons. Further, it identified a key developmental epoch, corresponding to the period of dendritic outgrowth and synaptogenesis, during which HGF stimulation elicits maximal activation of MET in the neocortex. PMID: 26818605
  9. Our results show that BMF-derived IL-6/HGF and cancer cell-derived TGF-b1 mediate the interactions between bone marrow-derived myofibroblasts and gastric cancer cells, which regulate cancer stemness and promote tumorigenesis. PMID: 27109105
  10. this study demonstrates an important role for HGF in the protective effects mediated by mesenchymal stromal cells in vivo in the bleomycin model of idiopathic pulmonary fibrosis PMID: 27388243
  11. HGF displays an antioxidant response by inducing the glutathione-related protection system. PMID: 27143995
  12. Exposure of macrophages to cyclooxygenase (COX-2) inhibitors RhoA and LA-4 cells to antagonists of prostaglandin E2 (PGE2) receptor , PGD2 receptors or the hepatocyte growth factor (HGF) receptor c-Met (PHA-665752), reversed EMT inhibition by the conditioned medium PMID: 26875548
  13. Notch signaling plays an important role in regulation of interactions between TGF-beta and HGF signaling pathways in proximal tubule epithelial cells PMID: 26739889
  14. inhibition of PPARgamma activity reversed the expression of transforming growth factor-beta (TGF-beta), interleukin (IL)-10, and hepatocyte growth factor (HGF). PMID: 25586556
  15. Molecular and functional studies revealed that ectopic Met expression in limb mesenchyme does not alter HGF expression patterns and levels, but impairs HGF bioavailability PMID: 26393505
  16. These data strongly indicate that paracrine Met signaling can control the function of luminal progenitors and modulate their fate during mammary development and tumorigenesis. PMID: 26165517
  17. These findings suggest that HGF overexpression can provide a potential therapeutic avenue as a combination therapy with disease-modifying therapies in SBMA. PMID: 26551462
  18. Apoptosis of cardiomyocytic & neuronal cells released HGF & HGF-mediated migration of mesenchymal stem cells towards apoptotic targets. HMGB1 was mainly released by necrotic cells& mediated recruitment of monocytes and immature dendritic cells PMID: 25571972
  19. Results indicate that the production of a second pool of HGF by myogenic cells, negatively regulated by NF-kappaB/p65, is crucial for inflammation resolution and the completion of repair in dystrophic skeletal muscle. PMID: 25906153
  20. Here, we report a novel hybrid mathematical modeling strategy to systematically unravel hepatocyte growth factor (HGF) stimulated phosphoinositide-3-kinase (PI3K) and mitogen activated protein kinase (MAPK) signal. PMID: 25905717
  21. findings provide novel insights into the cellular and molecular mechanisms mediating the essential role of HGF/c-Met signaling during oval cell-mediated mouse liver regeneration. PMID: 26001768
  22. We show that a subset of adult calcitonin gene-related peptide (CGRP)-expressing myenteric neurons produce MET, the receptor for hepatocyte growth factor. PMID: 26290232
  23. HGF entering alveoli from the bloodstream during pneumonia compensates for destruction by Dppi-activated inflammatory proteases to allow HGF to contribute to epithelial repair. PMID: 25938594
  24. HGF and c-met inhibition by means of a novel monoclonal neutralizing antibody inhibits tumor growth in prostate cancer cells and in mouse xenografts. PMID: 26093299
  25. HGF pathway is suggested to contribute to the lymphomagenesis in the MALT lymphoma after H. heilmannii infection. PMID: 25521737
  26. HGF/c-MET signaling promotes tumor formation after tissue injury in a mouse model of primary soft-tissue sarcoma PMID: 25503558
  27. HGF signaling through c-Met may decrease inflammation in endothelial cells and protect against intracranial aneurysm rupture. PMID: 25510828
  28. The enhanced thymic reconstitution in the rIL-7/HGFbeta-treated allogeneic BMT recipients results in increased number and functional activities of peripheral T cells. PMID: 24349415
  29. Regulation of Hgf expression by Hh signalling is indirect, mediated by Hedgehog-induced expression of the microRNAs miR-26a and miR-26b, which in turn downregulate expression of Hgf. PMID: 25362352
  30. upregulation of the COX-2/PGE2 and HGF in macrophages following exposure to apoptotic cells represents a mechanism for mediating the anti-inflammatory and antifibrotic consequences of apoptotic cell recognition PMID: 24959005
  31. It is a pleiotropic cytokine related with cell proliferation and survivaland ameliorates liver damage in viral hepatitis. PMID: 24224701
  32. In hepatic stellate cells, CYLD removed HDAC7 from the hepatocyte growth factor promoter and induced HGF expression. PMID: 24811579
  33. In conclusion, HGF, MACC1 and C-met genes involve into malignant cervical tumors occurrence, development and prognosis, and might become potential molecular target therapy site of cervical cancer PMID: 24469707
  34. selected 68 different antibodies that compete with HGF for binding to MET. HGF-competing antibodies recognized 4 distinct hotspots localized in different MET domains PMID: 24865428
  35. Differences in the intensity and quality of melanin biosynthesis as a result of HGF overexpression. PMID: 24223113
  36. Matriptase is required for the active form of hepatocyte growth factor induced Met, focal adhesion kinase and protein kinase B activation on neural stem/progenitor cell motility. PMID: 24685580
  37. these data provide evidence in support of a significant role for HGF-induced c-Met/PI3k/Akt signaling and NADPH oxidase activation in lamellipodia formation and motility of lung endothelial cells. PMID: 24634221
  38. In mechanism, Hgf expression is inhibited by NF-kappaB through suppression of PPARgamma function in the Hgf gene promoter. PMID: 24569592
  39. enhanced corneal HGF levels increase signaling through the c-met receptor, decrease mTOR levels, and enhance proinflammatory cytokines, while decreasing anti-inflammatory cytokines, and that HGF signaling is central to disease outcome. PMID: 24618323
  40. Preadipocyte-secreted HGF is an important regulator of neovascularization in developing fat pads. PMID: 24302003
  41. These results indicate that Hrs plays important roles during peripheral development and physiological functions of B lymphocytes. PMID: 24246674
  42. These results indicate that HGF/c-Met signaling is critical for beta-cell proliferation in situations of diminished beta-cell mass and suggest that activation of this pathway can enhance beta-cell regeneration. PMID: 24089510
  43. VEGF expression of CT26 cells was amplified through tumor-stromal interaction, i.e., the HGF paracrine loop. PMID: 23722408
  44. Adipose tissue derived stem cells from diabetic mice released lower amounts of HGF, a growth factor playing an important role in skin repair. PMID: 23627689
  45. HGF mediates the anti-inflammatory effects of platelet-rich plasma inn a mouse model of tendon injury. PMID: 23840657
  46. a new role of HGF in the modulation of signaling pathways implicated in the activation or repression of cardiomyogenesis PMID: 23224784
  47. These data suggest that the PI3K/Akt, MAPK and STAT3 pathways, downstream of HGF/cMet signalling, are involved in the regulation of VEGF expression PMID: 23233163
  48. The ERK/Akt pathway particularly may be critical in the HGF-induced Epithelial-mesenchymal transition process PMID: 23229794
  49. Circulating tumor cells have increased expression of HGF and c-Met in comparison to the primary tumor cells. PMID: 23723997
  50. Up-regulation of COX-2/PGE2 and HGF through a positive-feedback loop may be an important mechanism whereby apoptotic cell instillation exerts the net results of anti-inflammatory, antiapoptotic, and antifibrotic action. PMID: 23922381
  51. Murine macrophages promote in-vitro wound repair. PMID: 23773083
  52. The binding ability of mouse HGF alpha-chain, or of beta-chain, to human c-Met was lower than that of human HGF. PMID: 22996389
  53. Bone marrow progenitor cells release HGF, which inhibits miR-155-mediated profibrosis signaling, thereby preventing cardiac fibrosis. PMID: 23560074
  54. Conditional genetic elimination of hepatocyte growth factor in mice compromises liver regeneration after partial hepatectomy. PMID: 23527275
  55. These data suggest that IL-8 participates in the formation of cystic structures by Madin-Darby canine kidney cells in 3D culture and that HGF may stimulate tubulogenesis through the suppression of IL-8. PMID: 23485708
  56. we show that HGF signaling is necessary for alveolar homeostasis in the developing lung and that augmentation of HGF signaling can improve airspace morphology in murine emphysema. PMID: 23459311
  57. Data suggest that Hgf acts as antiapoptotic and differentiation factors in fetal Leydig cells; Hgf increases expression of insulin-like 3, marker of Leydig cell differentiation, and decreases expression of nestin, marker of Leydig cell progenitors. PMID: 23077169
  58. HGF is a growth factor playing a key role in islet mass increase and hyperinsulinemia in diet-induced obesity rats; the HGF-Met axis may have a role on insulin signaling in the liver PMID: 23024263
  59. In vivo inhibition of HGF-mediated c-Met activation blocked early, enhanced colon dysplasia in Tpl2-deficient mice, indicating that Tpl2 normally suppresses the HGF/c-Met pathway PMID: 23064365
  60. The findings indicate that in vivo exposure to apoptotic cells enhances transcriptional HGF production in bleomycin-stimulated lungs, resulting in attenuation of lung injury and fibrosis. PMID: 22441736
  61. Mer of the TAM-family receptors is responsible for mediating transcriptional HGF production through a RhoA-dependent pathway. PMID: 22740630
  62. These results demonstrate that modulation of learning and memory performance is an important physiological function of HGF that contributes to normal CNS plasticity PMID: 22535512
  63. HGF/c-Met plays a crucial role in host and donor cells of the liver for the cursiv selection of transplanted hepatocytes. Modulating HGF-dependent signalling seems a promising therapeutic option to favour expansion of transplanted hepatocytes. PMID: 22287599
  64. HGF is a biomarker and mediator in cardioprotection and cardiovascular regeneration [review] PMID: 22318499
  65. These studies indicate that HGF/c-Met signaling is essential for maternal beta-cell adaptation during pregnancy and that its absence/attenuation leads to gestational diabetes mellitus. PMID: 22427375
  66. The data showed that the activation of hepatocyte growth factor/c-Met signaling is a major pathway involved type II cell proliferation induced by ultrafine carbon black. PMID: 22245998
  67. Hepatocyte growth factor/c-met signaling is required for stem-cell-mediated liver regeneration in mice. PMID: 22095660
  68. investigated the role of SOCS1 in regulating hepatocyte proliferation following partial hepatectomy and HGF stimulation PMID: 21703184
  69. Data show that gradients of lymphatic fluid stasis regulate the expression of lymphangiogenic cytokines (VEGF-A, VEGF-C, and hepatocyte growth factor) and that paradoxically the expression of these molecules is increased in wild-type mice. PMID: 21940662
  70. HGF-induced migration was restored in myoblasts isolated from a transgenic mouse expressing alpha-syntrophin only in muscle cells. PMID: 22001117
  71. These results suggest that hepatocyte growth factor influences multiple steps in postnatal forebrain neurogenesis PMID: 21683144
  72. These studies are the first confirm that interference with the HGF/c-met/Stat3 signaling pathway can block tumor cell invasion in an in vivo model. PMID: 21595927
  73. the serum-induced increase in cell surface GLUT4 levels is not due to inhibition of its internalization and is not mediated by insulin, PDGF, IGF-1, or HGF PMID: 21187969
  74. In vivo administration of hybrid interleukin (IL)-7/HGFbeta chain following bone marrow transplantation supports rapid, complete thymic regeneration, efficiently reconstituting the naive T cell pool and its normally diverse receptor repertoire. PMID: 21209281
  75. HGF from local smooth muscle cells plays an important role for the differentiation of homing bone marrow mesenchymal stem cells. PMID: 21094172
  76. Even if serum HGF levels increased due to liver resection during the regeneration period, residual liver metastases of colorectal carcinoma was not promoted in its progression. PMID: 20596656
  77. Smad2 loss causes HGF upregulation via loss of Smad2-mediated transcriptional repression and enhanced Smad3/4-mediated transactivation. PMID: 20852387
  78. HGF and IGF-1 appear to play an important role during regeneration of the masseter muscle in mdx mice. PMID: 20508974
  79. controls satellite cell growth PMID: 20442248
  80. Data show that D74-HGF/c-Met axis defines a novel physiologic survival pathway in mature B cells, resulting in the control of the humoral immune response. PMID: 20639480
  81. Hepatocyte growth factor likely plays a role in cyclic endometrial remodeling, such as cell proliferation via autocrine/paracrine mechanisms in mouse uterus. PMID: 20147731
  82. Results indicate that HGF/c-met signaling has an important role in protecting podocytes from injury, thereby reducing proteinuria. PMID: 20375988
  83. ARHGAP12 inactivates RAC1, thereby impairing cell motility, invasion and adhesion to the extracellular matrix. The gene is transcriptionally suppressed by Hepatocyte Growth Factor in human and murine cell lines. PMID: 18504429
  84. Antigen-specific response assays showed that HGF is a potent immunomodulatory factor that inhibits dendritic cell (DC) function along with differentiation of IL-10-producing T(reg) cells and down-regulation of surface markers of T-cell activation. PMID: 20332205
  85. Matriptase/epithin participates in mammary epithelial cell growth and morphogenesis through HGF activation PMID: 19853659
  86. Appl proteins are required for HGF-induced cell survival and migration via activation of Akt PMID: 20040596
  87. These results highlight a defective thrombin-dependent proHGF activation system at the fibrotic phase of bleomycin-induced pulmonary fibrosis. PMID: 19448157
  88. Effects of thiol antioxidants on hepatocyte growth factor signaling in cardiac myocytes PMID: 11761336
  89. Hepatocyte growth factor induces ERK-dependent paxillin phosphorylation and regulates paxillin-focal adhesion kinase association PMID: 11784715
  90. Hepatocyte growth factor is essential for migration of myogenic cells and promotes their proliferation during the early periods of tongue morphogenesis in mouse embryos. PMID: 11836782
  91. HGF promotes hepatocarcinogenesis through the autocrine activation of HGF-c-met signaling pathway in association with stimulation of angiogenesis by HGF or indirectly through VFGF PMID: 11896611
  92. Mitogenic synergy through multilevel convergence of hepatocyte growth factor and interleukin-4 signaling pathways. PMID: 11948403
  93. important role of the c-met/scatter factor system in dendritic cell/langerhans cell migration PMID: 12115601
  94. estrogen may indirectly mediate mammary epithelial cell proliferation via the regulation of HGF in mammary stromal cells and HGF plays a crucial role in estrogen-induced proliferation in vivo PMID: 12193555
  95. is expressed during the embryonic development of the testis and has multiple roles during the morphogenesis of the male gonad PMID: 12351166
  96. data indicate that normal cerebellar development and, possibly, function, require HGF and Met, and that proliferation of granule cells in the cerebellum critically depends on full HGF/Met signaling PMID: 12397180
  97. HGF has a role in protecting the liver from chemical injury, but its isoforms stimulate injury PMID: 12482598
  98. hepatocyte growth factor is definitely involved in enhancing cutaneous wound healing processes, including re-epithelialization, neovascularization, and granulation tissue formation. PMID: 12542542
  99. Hepatocyte growth factor/scatter factor induces feedback up-regulation of CD44v6 in melanoma cells through Egr-1. PMID: 12670907
  100. Results suggest that osteopontin activity contributes to hepatocyte growth factor-induced tumor growth and invasiveness. PMID: 12915117

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Protein Families Peptidase S1 family, Plasminogen subfamily
Database Links

KEGG: mmu:15234

STRING: 10090.ENSMUSP00000030683

UniGene: Mm.267078

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