Mouse hepatocyte growth factor,HGF ELISA kit

Code CSB-E07347m
Size 96T,5×96T,10×96T
Trial Size 24T ELISA kits trial application
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Product Details

Target Name hepatocyte growth factor (hepapoietin A; scatter factor)
Alternative Names Hgf ELISA Kit; Hepatocyte growth factor ELISA Kit; Hepatopoietin-A ELISA Kit; Scatter factor ELISA Kit; SF) [Cleaved into: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain] ELISA Kit
Abbreviation HGF
Uniprot No. Q08048
Species Mus musculus (Mouse)
Sample Types
Detection Range
Sensitivity
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Cancer
Assay Principle quantitative
Measurement Sandwich
Precision   

Linearity  
  

Recovery   
Typical Data    

Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 3-5 working days

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Target Data

Function Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.
Gene References into Functions
  1. CBD-HGF combined with hydrogel scaffold may be promising for the treatment of serious SCI. PMID: 29343699
  2. these results suggested that HGF may exert beneficial effects on type II diabetesinduced chronic renal failure via regulation of the NFkappaB signaling pathway. PMID: 30066918
  3. HGF is beneficial for bone regeneration via increased expression of BMP-2, which leads to neovascularization and bone regeneration through regulation of the NF-kappaB signaling pathway. PMID: 29436622
  4. these findings highlight the relevance of cross-species protein interactions between murine feeder cells and human epithelial cells in 3T3-J2 co-culture and demonstrate that STAT6 phosphorylation occurs in response to MET activation in epithelial cells. However, STAT6 nuclear translocation does not occur in response to HGF, precluding the transcriptional activity of STAT6. PMID: 29771943
  5. prolonged treatment of single HGF/c-Met or Hh inhibitor leads to resistance to these single inhibitors, likely because the single c-Met treatment leads to enhanced expression of Shh, and vice versa. Targeting both the HGF/c-Met and Hh pathways simultaneously overcame the resistance to the single-inhibitor treatment and led to a more potent antitumor effect in combination with the chemotherapy treatment. PMID: 28864680
  6. These results indicate that expression and production of HGF are regulated in a species-specific adipogenic differentiation-dependent manner and suggest that the decrease in HGF mRNA in mouse differentiated adipocytes is, at least in part, mediated by differentiation-dependent loss of its stability. PMID: 29040876
  7. Mesenchymal stem cells microvesicles stabilization of endothelial barrier function is partly mediated by hepatocyte growth factor. PMID: 28969681
  8. Study used biochemical and morphological analyses to demonstrate that two discrete intracellular signaling pathways underlie distinct HGF-induced biological outcomes in developing neocortical neurons. Further, it identified a key developmental epoch, corresponding to the period of dendritic outgrowth and synaptogenesis, during which HGF stimulation elicits maximal activation of MET in the neocortex. PMID: 26818605
  9. Our results show that BMF-derived IL-6/HGF and cancer cell-derived TGF-b1 mediate the interactions between bone marrow-derived myofibroblasts and gastric cancer cells, which regulate cancer stemness and promote tumorigenesis. PMID: 27109105
  10. this study demonstrates an important role for HGF in the protective effects mediated by mesenchymal stromal cells in vivo in the bleomycin model of idiopathic pulmonary fibrosis PMID: 27388243
  11. HGF displays an antioxidant response by inducing the glutathione-related protection system. PMID: 27143995
  12. Exposure of macrophages to cyclooxygenase (COX-2) inhibitors RhoA and LA-4 cells to antagonists of prostaglandin E2 (PGE2) receptor , PGD2 receptors or the hepatocyte growth factor (HGF) receptor c-Met (PHA-665752), reversed EMT inhibition by the conditioned medium PMID: 26875548
  13. Notch signaling plays an important role in regulation of interactions between TGF-beta and HGF signaling pathways in proximal tubule epithelial cells PMID: 26739889
  14. inhibition of PPARgamma activity reversed the expression of transforming growth factor-beta (TGF-beta), interleukin (IL)-10, and hepatocyte growth factor (HGF). PMID: 25586556
  15. Molecular and functional studies revealed that ectopic Met expression in limb mesenchyme does not alter HGF expression patterns and levels, but impairs HGF bioavailability PMID: 26393505
  16. These data strongly indicate that paracrine Met signaling can control the function of luminal progenitors and modulate their fate during mammary development and tumorigenesis. PMID: 26165517
  17. These findings suggest that HGF overexpression can provide a potential therapeutic avenue as a combination therapy with disease-modifying therapies in SBMA. PMID: 26551462
  18. Apoptosis of cardiomyocytic & neuronal cells released HGF & HGF-mediated migration of mesenchymal stem cells towards apoptotic targets. HMGB1 was mainly released by necrotic cells& mediated recruitment of monocytes and immature dendritic cells PMID: 25571972
  19. Results indicate that the production of a second pool of HGF by myogenic cells, negatively regulated by NF-kappaB/p65, is crucial for inflammation resolution and the completion of repair in dystrophic skeletal muscle. PMID: 25906153
  20. Here, we report a novel hybrid mathematical modeling strategy to systematically unravel hepatocyte growth factor (HGF) stimulated phosphoinositide-3-kinase (PI3K) and mitogen activated protein kinase (MAPK) signal. PMID: 25905717
  21. findings provide novel insights into the cellular and molecular mechanisms mediating the essential role of HGF/c-Met signaling during oval cell-mediated mouse liver regeneration. PMID: 26001768
  22. We show that a subset of adult calcitonin gene-related peptide (CGRP)-expressing myenteric neurons produce MET, the receptor for hepatocyte growth factor. PMID: 26290232
  23. HGF entering alveoli from the bloodstream during pneumonia compensates for destruction by Dppi-activated inflammatory proteases to allow HGF to contribute to epithelial repair. PMID: 25938594
  24. HGF and c-met inhibition by means of a novel monoclonal neutralizing antibody inhibits tumor growth in prostate cancer cells and in mouse xenografts. PMID: 26093299
  25. HGF pathway is suggested to contribute to the lymphomagenesis in the MALT lymphoma after H. heilmannii infection. PMID: 25521737
  26. HGF/c-MET signaling promotes tumor formation after tissue injury in a mouse model of primary soft-tissue sarcoma PMID: 25503558
  27. HGF signaling through c-Met may decrease inflammation in endothelial cells and protect against intracranial aneurysm rupture. PMID: 25510828
  28. The enhanced thymic reconstitution in the rIL-7/HGFbeta-treated allogeneic BMT recipients results in increased number and functional activities of peripheral T cells. PMID: 24349415
  29. Regulation of Hgf expression by Hh signalling is indirect, mediated by Hedgehog-induced expression of the microRNAs miR-26a and miR-26b, which in turn downregulate expression of Hgf. PMID: 25362352
  30. upregulation of the COX-2/PGE2 and HGF in macrophages following exposure to apoptotic cells represents a mechanism for mediating the anti-inflammatory and antifibrotic consequences of apoptotic cell recognition PMID: 24959005
  31. It is a pleiotropic cytokine related with cell proliferation and survivaland ameliorates liver damage in viral hepatitis. PMID: 24224701
  32. In hepatic stellate cells, CYLD removed HDAC7 from the hepatocyte growth factor promoter and induced HGF expression. PMID: 24811579
  33. In conclusion, HGF, MACC1 and C-met genes involve into malignant cervical tumors occurrence, development and prognosis, and might become potential molecular target therapy site of cervical cancer PMID: 24469707
  34. selected 68 different antibodies that compete with HGF for binding to MET. HGF-competing antibodies recognized 4 distinct hotspots localized in different MET domains PMID: 24865428
  35. Differences in the intensity and quality of melanin biosynthesis as a result of HGF overexpression. PMID: 24223113
  36. Matriptase is required for the active form of hepatocyte growth factor induced Met, focal adhesion kinase and protein kinase B activation on neural stem/progenitor cell motility. PMID: 24685580
  37. these data provide evidence in support of a significant role for HGF-induced c-Met/PI3k/Akt signaling and NADPH oxidase activation in lamellipodia formation and motility of lung endothelial cells. PMID: 24634221
  38. In mechanism, Hgf expression is inhibited by NF-kappaB through suppression of PPARgamma function in the Hgf gene promoter. PMID: 24569592
  39. enhanced corneal HGF levels increase signaling through the c-met receptor, decrease mTOR levels, and enhance proinflammatory cytokines, while decreasing anti-inflammatory cytokines, and that HGF signaling is central to disease outcome. PMID: 24618323
  40. Preadipocyte-secreted HGF is an important regulator of neovascularization in developing fat pads. PMID: 24302003
  41. These results indicate that Hrs plays important roles during peripheral development and physiological functions of B lymphocytes. PMID: 24246674
  42. These results indicate that HGF/c-Met signaling is critical for beta-cell proliferation in situations of diminished beta-cell mass and suggest that activation of this pathway can enhance beta-cell regeneration. PMID: 24089510
  43. VEGF expression of CT26 cells was amplified through tumor-stromal interaction, i.e., the HGF paracrine loop. PMID: 23722408
  44. Adipose tissue derived stem cells from diabetic mice released lower amounts of HGF, a growth factor playing an important role in skin repair. PMID: 23627689
  45. HGF mediates the anti-inflammatory effects of platelet-rich plasma inn a mouse model of tendon injury. PMID: 23840657
  46. a new role of HGF in the modulation of signaling pathways implicated in the activation or repression of cardiomyogenesis PMID: 23224784
  47. These data suggest that the PI3K/Akt, MAPK and STAT3 pathways, downstream of HGF/cMet signalling, are involved in the regulation of VEGF expression PMID: 23233163
  48. The ERK/Akt pathway particularly may be critical in the HGF-induced Epithelial-mesenchymal transition process PMID: 23229794
  49. Circulating tumor cells have increased expression of HGF and c-Met in comparison to the primary tumor cells. PMID: 23723997
  50. Up-regulation of COX-2/PGE2 and HGF through a positive-feedback loop may be an important mechanism whereby apoptotic cell instillation exerts the net results of anti-inflammatory, antiapoptotic, and antifibrotic action. PMID: 23922381

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Protein Families Peptidase S1 family, Plasminogen subfamily
Database Links

KEGG: mmu:15234

STRING: 10090.ENSMUSP00000030683

UniGene: Mm.267078

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