Recombinant Human Insulin-like growth factor I(IGF1),partial

In Stock
Code CSB-AP003721HU
Product Type Growth Factor
Size US$33
Uniprot No. P05019
Lead Time 5-10 business days
Storage Buffer Lyophilized from a 0.2 μm Filtered 20 mM NaAc-HAC, pH 4.5
Alias Insulin-Like Growth Factor I; IGF-I; Mechano Growth Factor; MGF; Somatomedin-C; IGF1; IBP1
Species Homo sapiens (Human)
Biological_Activity The ED50 as determined in a serum-free cell proliferation assay using MCF?7 human breast cancer cells is typically 1-8 ng/mL
Purity Greater than 95% as determined by SDS-PAGE.
Endotoxin Less than 0.5 EU/μg as determined by LAL method.
Sequence TLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA
Research Area Signal Transduction
Source E.coli
Gene Names IGF1
Expression Region 52-118aa
Tag Info Tag-Free
Mol. Weight 7.3 kDa
Protein Description Partial
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Function The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation
Involvement in disease Insulin-like growth factor I deficiency (IGF1 deficiency)
Subcellular Location Secreted
Protein Families Insulin family
Database Links

HGNC: 5464

OMIM: 147440

KEGG: hsa:3479

STRING: 9606.ENSP00000302665

UniGene: Hs.160562

Pathway HIF-1 signaling pathway
MAPK signaling pathway
mTOR signaling pathway
p53 signaling pathway
PI3K-Akt signaling pathway
Focal adhesion
Ras signaling pathway
Signaling pathways regulating pluripotency of stem cells
AMPK signaling
FoxO signaling pathway
Rap1 signaling pathway

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