Recombinant Human Interleukin-1 alpha protein(IL1A) (Active)

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Code CSB-AP001661HU
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Product Details

Purity >97% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine D10S cells is less than 1.0 pg/ml, corresponding to a specific activity of >1.0x109 IU/mg.
Target Names IL1A
Uniprot No. P01583
Research Area Immunology
Alternative Names BAF; FAF; Hematopoietin 1; Hematopoietin-1; IL 1 alpha; IL 1A; IL-1 alpha; Il-1a; IL1 ALPHA; IL1; IL1A; IL1A_HUMAN; IL1F1; Interleukin 1 alpha; Interleukin-1 alpha; Interleukin1 alpha; LAF; LEM; Preinterleukin 1 alpha; Pro interleukin 1 alpha
Species Homo sapiens (Human)
Source E.coli
Expression Region 113-271aa
Complete Sequence SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA
Mol. Weight 18.0 kDa
Protein Length Full Length of Mature Protein
Tag Info Tag-Free
Form Lyophilized powder
Buffer Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 5-10 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
Gene References into Functions
  1. Based on the available data, C/T genotype of the rs1800587 polymorphism within IL1A gene may be associated with an increased Graves' disease risk. PMID: 29879187
  2. IL-1 was positively related with increased BMI overweight and obesity PMID: 30070872
  3. IL-1alpha is detectable in the majority of patients with infrarenal abdominal aortic aneurysms. PMID: 29456054
  4. Meta-analysis suggests that the IL-1B rs16944 polymorphism is a susceptibility risk factor for febrile seizures in Caucasian and Asian populations. The IL-1B rs1143627, IL-1B rs1143634, and IL-1A rs1800587 polymorphisms are not associated with febrile seizure risk. PMID: 29808330
  5. The IL-1b+3954 C/T polymorphism significantly increases RAS risk. In addition, the IL-10-1082 G/A polymorphism provided protective effects for RAS in the Asian population PMID: 29641282
  6. The single nucleotide polymorphism (SNP) of IL-1beta gene (rs3917356G>A) increased the risk of HCC in the recessive model (p<0.001, OR=2.58, 95% CI=1.53-4.33), whereas other SNPs in IL-1alpha and IL-1RA showed no significant association between Hepatocellular carcinoma patients and controls. PMID: 29802240
  7. our findings proposed an association between IL1A 4-bp ins/del polymorphism and risk of prostate cancer PMID: 29023981
  8. effect of IL-22 on Intestinal Epithelial Cells responses may not be in inducing CXCL8 by itself, but in enhancing TNF-alpha- and IL-1-induced CXCL8 secretion to augment the contribution of IECs to local inflammatory responses. PMID: 28656529
  9. Our pilot study demonstrated a correlation between the individual genetic inflammatory profile and the efficacy of the platelet rich plasma treatment in males PMID: 29228441
  10. the present study was intended to determine whether single-nucleotide polymorphisms (SNPs) in the IL-1 gene cluster are also associated with periodontal disease in a Linkage disequilibrium analysis PMID: 29577711
  11. No significant difference was seen in mRNA levels among different promoter genotype for IL1A in SCA3 patients vs. controls, except a previously reported higher level in those with the IL1A*T allele. These patients also showed an earlier age of onset than those homozygous for IL1A*C. PMID: 27246313
  12. Obesity was associated with higher expression of NILCO molecules (Notch-IL1-leptin) in type II endometrial cancer. PMID: 28659656
  13. This meta-analysis with 2,174 patients with chronic periodontitis and 1, 756 controls evidenced the -889 C/T polymorphism is associated to risk of development of chronic periodontitis with no significant value to heterogeneity to allelic evaluation PMID: 27918732
  14. through IL-1alpha production, airway epithelial cells induce a pro-inflammatory lung fibroblast phenotype that is further enhanced with cigarette smoke extract exposure in COPD, suggesting an aberrant epithelial-fibroblast interaction in COPD PMID: 27418555
  15. our study has described the association between rs3783550 (IL-1A), rs3783546 (IL-1A) and rs2853550 (IL-1B) and AS risk and between a new haplotype, "TCG", of rs3783550, rs3783546 and rs2853550 and AS in Chinese Han population. PMID: 28423679
  16. Unicystic Ameloblastoma patients with high IL-1alpha expression in the lesion responded better to marsupialization than those in whom the expression of the protein was low, and therefore show a greater reduction of the cystic space after marsupialization. PMID: 29419674
  17. In conclusion, the analyzed IL1A -889 C>T, IL1B +3954 C>T, and IL6 -174 G>C polymorphisms may be associated with the occurrence and development of human cytomegalovirus infection among studied patients. PMID: 28151075
  18. Lipid apheresis suppresses the expression of IL-1alpha, IL-6 and TNF-alpha mRNA in patients with dyslipidaemias. PMID: 29096839
  19. results suggest a role for prostatic expression of TGF-B, IL-1a, TGFBRI and TGFBRII as prognostic markers for prostate cancer. The rational combination of novel agents directed toward the inactivation of TGF-B, IL-1a, TGFBRI and TGFBRII could disrupt complementary tumor cell proliferation pathways. PMID: 27527810
  20. There were no significant differences in GE area of infertile and fertile women. C-C motif chemokine 11 (P=0.048), TGFalpha (P=0.049), IFNgamma (P=0.033) and interleukin-1 alpha (P=0.047) were significantly elevated in uterine lavage from infertile women <35years compared to fertile but not in women 35years PMID: 27525354
  21. The authors' findings suggest that IL-1a rs3783553 polymorphism may modulate the risk of squamous cell carcinoma of the oropharynx recurrence in patients, particularly for patients with HPV16-positive tumors. PMID: 27121322
  22. IL-1alpha released from necrotic corneal epithelial cells may trigger inflammatory responses at the ocular surface, including cytokine production and barrier disruption. PMID: 28725984
  23. Based on current meta-analysis, we indicated that there is lack of association between the three SNPs of IL-1 and primary open-angle glaucoma. PMID: 29179746
  24. results showed that IL-1A -889C/T (rs1800587) was associated with systemic sclerosis susceptibility in the Chinese population PMID: 27098064
  25. Reconstitution of ST2 (IL-1R4) specific for IL-33 activity; no suppression by IL-1Ra though a common chain IL-1R3 (IL-1RAcP) shared with IL-1. PMID: 27031441
  26. A SNP in IL1A were associated with keratoconus in Chinese Han patients PMID: 26200829
  27. these findings highlight the interaction between IL-6 and IL-1alpha to generate an inflammatory microenvironment in driving (PSMA,PSA) prostate clones PMID: 27451139
  28. MSCs primed with IL-1alpha or IL-1beta showed increased secretion of G-CSF, which was blocked by IL-1Ra. PMID: 28412968
  29. rs3783553 ins/ins genotype may increase the susceptibility to ischemic stroke, possibly by interrupting the binding site of miR-122 and miR-378 PMID: 29145255
  30. The abnormalities in hormonal/biochemical parameters detected in Turkish polycystic ovary syndrome patients may be related with IL-6 gene polymorphism rather than IL-1A. PMID: 28019133
  31. Major D allele of IL-1A (I/D) gene polymorphism is associated with NAFLD in the Egyptian population PMID: 28627263
  32. Interleukin-1alpha induces release of interleukin-8 by human bronchial epithelial cells PMID: 28078769
  33. the results indicate prominent antagonistic effects of IL-1alpha on TGF-beta regulated interferon signaling, as well as on a wide variety of other genes and pathways in fibroblasts. PMID: 26629874
  34. IL1A polymorphism rs1800587 is associated with chronic pain in patients with sickle cell disease. PMID: 27883292
  35. Data indicate that interleukin 1alpha (IL-1alpha) propiece can activate NF-kappa B (NFkappaB) and Sp1 transcription factor (SP1). PMID: 28152513
  36. cytokines of the IL-1 family play an important role in homeostatic as well as "emergency" hematopoiesis and are involved in the pathogenesis of several myeloid and lymphoid hematological malignancies. PMID: 28483765
  37. These results suggest that IL-1alpha enhances the translocation of TRPA1 to the plasma membrane via the activation of Erk in A549. PMID: 28629997
  38. Single Nucleotide Variants of Candidate Genes in Aggrecan Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes PMID: 28081267
  39. Polymorphisms of Il1a were not significantly associated with bipolar I disorder in Iranian patients. PMID: 28129679
  40. This meta-analysis suggested that the IL-1alpha (+889C/T) polymorphism is significantly associated with risk of Intervertebral Disc Degeneration, especially in Caucasian populations. PMID: 27253397
  41. we show that IL-1 induces robust p38a activation both in the nucleus and in the cytoplasm/membrane.Following stimulation, p38a activity returns to a basal level in absence of receptor degradation. While nuclear pulse is controlled by MKP1 through a negative feedback to pp38, its basal activity is controlled by both TAB1 and MKP1 through a positive feedback loop. PMID: 27314954
  42. Key aspects of IL-1alpha biology and regulation, especially its emerging importance in the initiation and maintenance of inflammation that underlie the pathology of many human diseases, are reviewed. Review. PMID: 27434011
  43. This study demonstrates that the rs3783553 polymorphism may be involved in susceptibility to endometrial cancer. The II genotype seems to be a protective factor for endometrial cancer in Chinese Han women. PMID: 27136893
  44. Circulating Il1a levels were not altered in nonalcoholic fatty liver disease. PMID: 27493109
  45. The IL-1alpha rs1800587 polymorphism demonstrated a significant association with the childhood type 1 diabetes mellitus risk. PMID: 27706611
  46. The percentage of the -889 promotor SNP was similar but not overlapping in all the groups: periodontal disease only (40.8%), PD plus rheumatoid arthritis (50.2%), and PD plus NIDDM (46%). PMID: 27655512
  47. this study shows that IL-1a gene variants are not associated with susceptibility to juvenile idiopathic arthritis in Iranian population PMID: 27717726
  48. IL1 and IL6 are important components of the tumor microenvironment, displaying multiple functions. These cytokines take part at all stages of oncogenesis: from initiation to tumor, invasion, and metastasis of already established malignant and mutant epithelial cells. [Review] PMID: 27260388
  49. IL-1genotype has no effect on Antibiotic Resistance on Helicobacter pylori Eradication. PMID: 27221874
  50. Genetic polymorphisms in the IL1A, IL1B, IL2 and IL6 genes are not genetic modulators of depression in a cohort of Polish subjects. PMID: 26934083
  51. functional polymorphism rs3783553 in IL-1A could contribute to gastric cancer susceptibility, possibly or at least partially through affecting the transcriptional activity of IL-1A. PMID: 26889982
  52. The prevalence of the CT genotype of IL1A rs17561 polymorphism was increased in preeclamptic women compared with controls. PMID: 25902400
  53. IL-1alpha directly sense DNA damage and act as signal for genotoxic stress without loss of cell integrity.IL-1A is linking genotoxic stress signaling to sterile inflammation and innate immunity. PMID: 26439902
  54. IL-1A rs17561 and IL-1B rs1143634 polymorphisms are associated with periodontitis. PMID: 26909953
  55. A functional insertion/deletion polymorphism in the IL1A gene is associated with decreased risk of breast cancer. PMID: 26909967
  56. Reported is the distribution of allelic and genotypic frequencies of IL1A, IL4, NFKB1 and PAR1 variants in Native American, African, and European populations of Brazil and their association with predisposition to cancer. PMID: 26879815
  57. significant differences were found in carriage rate of both minor alleles of IL-1A (C-889T) and IL-1B (C+3954T) polymorphisms of aggressive periodontitis (AgP) cases compared with healthy controls in the Algerian population; the polymorphisms of the IL-1 genes appear to be associated with susceptibility to AgP in the Algerian population PMID: 26263533
  58. Suggest that IL-1alpha rs17561 polymorphism may not be associated with susceptibility to Tourette syndrome in Chinese Han population. PMID: 26097611
  59. Letter: Knockdown of either filaggrin or loricrin increases the productions of interleukin (IL)-1alpha, IL-8, IL-18 and granulocyte macrophage colony-stimulating factor in stratified human keratinocytes. PMID: 26381575
  60. No Alzheimer's disease relation with IL-1a C889T polymorphisms for this study. PMID: 23038715
  61. Report a significant relationship between IL-1alpha expression and development of distant metastasis in head and neck squamous cell carcinoma patients. PMID: 26460957
  62. The study investigates Il-1 gene cluster polymorphisms and their association with coronary artery disease. Significant differences in association statuses were seen for IL1A +4845 G>T, IL1B -511 C>T. PMID: 27078871
  63. the Ins/Del polymorphism in the 3'UTR of IL1A may affect genetic expression; the minor allele (Del) is associated with an elevated risk for osteoarthritis and disease severity PMID: 26239639
  64. Data show that the expressions of interleukins IL-1 and IL-6 in the discs of discogenic low back pain (DLBP) patients were significantly elevated and negatively correlated with the Japanese Orthopedic Association (mJOA) scores of low back pain. PMID: 26728383
  65. This study demonstrate a significant association of the IL-1A-889 functional polymorphism with Coronary Artery Disease. PMID: 25617388
  66. Inactivation of the EGFR with a blocking antibody decreased the S. aureus-mediated IL-1alpha induction in primary keratinocytes. Inflammasomes mediate induced secretion but not induced gene expression of IL-1alpha. PMID: 26808616
  67. The aim of this study was to evaluate the effect of IL1A rs3783553 on CRC risk. CRC patients (N = 339) and healthy control subjects (N = 313) PMID: 26345777
  68. Our findings suggest that the IL-1A-899C/C genotype and C allele are associated with susceptibility to preeclampsia. PMID: 26254854
  69. Patients with better muscle function had the highest concentration of CK, IL-1, and TNF-a compared with less muscle function PMID: 26380303
  70. Lung tumor-associated plasmacytoid dendritic cells (pDCs) are responsive to the activation of AIM2 that promotes calcium efflux and reactive oxygen species from mitochondria, leading to calpain activation and high levels of IL-1alpha. PMID: 26506473
  71. Results indicate that the nuclear localization sequence of human pIL-1a is a novel human-derived Cell penetrating peptide that can deliver macromolecules such as a protein into the cells in vitro and in vivo. PMID: 25205122
  72. recombinant SERPINE2 induced a clear inhibition of MMP-13 expression in IL-1alpha-stimulated chondrocytes. This inhibitory effect is likely regulated through a pathway involving ERK 1/2, NF-kappaB and AP-1 PMID: 26305372
  73. meta-analysis. Our results indicate that IL-6, IL-1A, and IL-1B genetic polymorphisms are statistically correlated with an increased risk of osteoarthritis under the allele and dominant models. PMID: 24952309
  74. IL-1a gene polymorphisms were associated with more severe impairments after stroke. PMID: 25223242
  75. An insertion/deletion polymorphism (rs3783553) in the IL1A 3' untranslated region may disrupt a binding site for miR-122 and miR-378 PMID: 25955681
  76. SNPs within the IL1A gene are associated with endometriosis risk. PMID: 25336714
  77. Data indicate significant decreases in the expression of interleukin-1alpha (IL-1 alpha) mRNA after 72 h incubation with 5 - 50 mu M ondansetron. PMID: 25098424
  78. The IL1A (T)/IL1RN (A) genotype, but not the IL1B (T)/IL1RN (A) genotype, may increase the risk of a chronic pain outcome in patients following disc herniation. PMID: 25207923
  79. IL-1alpha acts as an alarmin essential for leukocyte recruitment and protective immunity against HSV-1 PMID: 25323745
  80. The data suggest that TNFA (-857) C/T and IL-1A (-889) C/T polymorphisms are not associated with susceptibility to aggressive periodontitis in this Romanian population PMID: 26193214
  81. Necroptotic cervical cancer cells released IL-1alpha, which was required for powerful activation of dendritic cells to produce IL-12. Both IL-1alpha release and DC activation were strictly dependent on RIPK3. PMID: 25888634
  82. Our findings suggest that the IL-6-572C and IL-1A-889T alleles may contribute to the pathogenesis of acne in a Pakistani population. PMID: 25432444
  83. TTCA insertion allele of rs3783553 contributes to reduce the individual's susceptibility for preeclampsia PMID: 24839866
  84. Interleukin-1alpha Activity in Necrotic Endothelial Cells Is Controlled by Caspase-1 Cleavage of Interleukin-1 Receptor-2 PMID: 26324711
  85. IL-1a is a strong positive regulator of ADAMTS-2 and ADAMTS-3 expression. PMID: 26232334
  86. Data indicate that the interleukin (IL)-1 family of cytokines are key regulators of the inflammatory network. PMID: 25693732
  87. The frustrated host response to Legionella pneumophila is bypassed by MyD88-dependent translation of pro-inflammatory cytokines. PMID: 25058342
  88. Choriodecidual tissue punches released IL-1alpha and IL-1beta in response to group-B-Streptococcus and this medium significantly stimulated release of HBD-2 by amnion cell cultures. PMID: 25263616
  89. MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation. PMID: 26147250
  90. IL1RN and IL1A may involve in the development of PE in Chinese Han population. PMID: 24918527
  91. data suggest that central inhibition of IL-1alpha or Tox3 overexpression during the acute phase of a CNS insult may be an effective means for preventing the loss of neurological function PMID: 26224856
  92. IL-1alpha may have an important role as marker of both inflammation and hepatic injury, particularly in the course of hepatitis C PMID: 26040073
  93. The development of thrombocytopenia in patients with CLL is associated with genetic variants -889T IL-1A (OR=1,95), -889TT IL-1A (OR=6,2) and IL-1Ra*1 (OR=-2,32). PMID: 25826984
  94. Higher levels of IL-1beta and IL-1alpha were found in peripheral blood mononuclear cells supernatants of patients during crises compared to those in remission and to controls. PMID: 25025954
  95. The findings of this study suggest that the IL-1alpha SNP rs1800587 contribute to late-onset Alzheimers disease susceptibility in the Hunan Han Chinese population. PMID: 25446437
  96. results suggested that IL-1alpha-889C/T polymorphism is associated with stroke risk, especially in Asians PMID: 25917615
  97. the rs3783550 polymorphism in the interleukin 1 alpha gene is correlated to pre-eclampsia, indicating that women with the allele A have a higher probability of developing the disease. PMID: 25322977
  98. This study suggests that rs3783553 polymorphism at miRNA-122 binding site in the IL-1A 3'UTR may be involved in the susceptibility to epithelial ovarian cancer PMID: 25195148
  99. Data show that interleukin-1alpha secreted from oral squamous cell carcinoma cells not only promoted the proliferation of carcinoma-associated fibroblasts (CAFs) but also upregulated the secretion of cytokines in CAFs. PMID: 25425967
  100. The polarization of memory T cells into Th17 cells is mediated via membrane IL-1alpha (mIL-1alpha), which is constitutively expressed by M-CSF-, IL-34 macrophages, and tumor-associated macrophages. PMID: 25545357

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Subcellular Location Secreted
Protein Families IL-1 family
Database Links

HGNC: 5991

OMIM: 147760

KEGG: hsa:3552

STRING: 9606.ENSP00000263339

UniGene: Hs.1722

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