IL1A, Interleukin 1α, alias IL-1α, Hematopoietin-1, Lymphocyte-Activating Factor (LAF), Endogenous Pyrogen (EP), and IL1F1. It is a pleiotropic cytokine encoded by the IL1A gene and is mainly produced by activated macrophages, neutrophils, epithelial cells and endothelial cells.The mechanism of action of IL1A involves the intracellular transcription factor function of its precursor proteins as well as extracellular signaling by its mature form.IL1A precursor promotes gene expression in the nucleus of the cell and regulates cell growth and differentiation. The mature form of IL1A triggers the formation of signaling complexes by binding to the IL-1 receptor IL1R1 on the cell surface, activating the NF-kappa-B and MAPK pathways, thereby triggering inflammatory and immune responses .
Biologically, IL1A plays a key role in the inflammatory response, immune regulation, and association with various diseases. It is involved in the regulation of the body's resistance to microbial infections, sterile inflammation, tumor-associated diseases, and spontaneous inflammation.Aberrant expression of IL1A has been associated with a wide range of diseases, including Fabry disease, Schnitzler's syndrome, various autoimmune diseases, hematologic neoplasms, and lung diseases. Therefore, IL1A is an important molecular target in the study of inflammatory and immune-related diseases, and is a potential marker and therapeutic target for the clinical treatment of many diseases .
Recombinant Human Interleukin-1 alpha (IL1A) (CSB-YP011613HU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Validated Data
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA584603(IL1A Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA584603(IL1A Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Jurkat cells, Primary antibody: CSB-PA584603(IL1A Antibody) at dilution 1/666, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
Human Interleukin 1α,IL-1α ELISA Kit (CSB-E04620h)
Validated Data
Code: CSB-E04620h
Size: 96T,5×96T,10×96T
Sensitivity: 0.975 pg/ml.
Detection Range: 3.9 pg/ml-250 pg/ml.
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
The following IL1A reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
IL1A Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA06565A0Rb | IL1A Antibody | Human | ELISA |
CSB-PA06565C0Rb | IL1A Antibody, FITC conjugated | Human | |
CSB-PA011613GA01HU | IL1A Antibody | Human | ELISA,WB |
CSB-PA009537 | IL1A Antibody | Human,Mouse,Rat | IHC, ELISA |
CSB-PA107052 | IL1A Antibody | Human | ELISA,IHC |
CSB-PA584603 | IL1A Antibody | Human | ELISA,WB,IHC |
IL1A Antibodies for Macaca mulatta
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA011613LA01MOW | IL1A Antibody | Macaca mulatta, Human | ELISA, WB |
IL1A Antibodies for Mus musculus (Mouse)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA011613XA01MO | Il1a Antibody | Mus musculus (Mouse) | ELISA, WB (ensure identification of antigen) |
IL1A Proteins for Capra hircus (Goat)
Code | Product Name | Source |
---|---|---|
CSB-YP011613GO CSB-EP011613GO CSB-BP011613GO CSB-MP011613GO CSB-EP011613GO-B |
Recombinant Goat Interleukin-1 alpha (IL1A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP011613PI CSB-EP011613PI CSB-BP011613PI CSB-MP011613PI CSB-EP011613PI-B |
Recombinant Pig Interleukin-1 alpha (IL1A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A Proteins for Macaca mulatta (Rhesus macaque)
Code | Product Name | Source |
---|---|---|
CSB-EP011613MOW | Recombinant Macaca mulatta Interleukin-1 alpha (IL1A) | E.coli |
CSB-YP011613MOW | Recombinant Macaca mulatta Interleukin-1 alpha (IL1A) | Yeast |
CSB-AP003071MOW | Recombinant Macaca mulatta Interleukin-1 alpha (IL1A) (Active) | E.coli |
CSB-BP011613MOW CSB-MP011613MOW CSB-EP011613MOW-B |
Recombinant Macaca mulatta Interleukin-1 alpha (IL1A) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP011613MO CSB-EP011613MO CSB-BP011613MO CSB-MP011613MO CSB-EP011613MO-B |
Recombinant Mouse Interleukin-1 alpha (Il1a) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-AP003251MO | Recombinant Mouse Interleukin-1 alpha protein (Il1a) | E.Coli |
CSB-AP004721MO | Recombinant Mouse Interleukin-1 alpha (Il1a) (Active) | E.coli |
IL1A Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-BP011613HU CSB-MP011613HU |
Recombinant Human Interleukin-1 alpha (IL1A) | Baculovirus Mammalian cell |
CSB-AP001661HU | Recombinant Human Interleukin-1 alpha protein (IL1A) (Active) | E.coli |
CSB-EP011613HUe0 | Recombinant Human Interleukin-1 alpha (IL1A) | E.coli |
CSB-YP011613HUc7 | Recombinant Human Interleukin-1 alpha (IL1A) | Yeast |
CSB-AP004261HU | Recombinant Human Interleukin-1 alpha (IL1A) (Active) | E.coli |
CSB-EP011613HU | Recombinant Human Interleukin-1 alpha (IL1A) | E.coli |
CSB-AP005801HU | Recombinant Human Interleukin-1 alpha (IL1A) (Active) (GMP) | E.Coli |
CSB-YP011613HU | Recombinant Human Interleukin-1 alpha (IL1A) | Yeast |
CSB-EP011613HU-B | Recombinant Human Interleukin-1 alpha (IL1A),Biotinylated | E.coli |
IL1A Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP011613BO CSB-EP011613BO CSB-BP011613BO CSB-MP011613BO CSB-EP011613BO-B |
Recombinant Bovine Interleukin-1 alpha (IL1A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A Proteins for Oryctolagus cuniculus (Rabbit)
Code | Product Name | Source |
---|---|---|
CSB-YP011613RB CSB-EP011613RB CSB-BP011613RB CSB-MP011613RB CSB-EP011613RB-B |
Recombinant Rabbit Interleukin-1 alpha (IL1A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A Proteins for Felis catus (Cat) (Felis silvestris catus)
Code | Product Name | Source |
---|---|---|
CSB-YP011613CA CSB-EP011613CA CSB-BP011613CA CSB-MP011613CA CSB-EP011613CA-B |
Recombinant Cat Interleukin-1 alpha (IL1A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
Code | Product Name | Source |
---|---|---|
CSB-YP011613DO CSB-EP011613DO CSB-BP011613DO CSB-MP011613DO CSB-EP011613DO-B |
Recombinant Dog Interleukin-1 alpha (IL1A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Code | Product Name | Source |
---|---|---|
CSB-BP011613MOV CSB-MP011613MOV CSB-EP011613MOV-B |
Recombinant Macaca fascicularis Interleukin-1 alpha (IL1A) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP011613RA CSB-EP011613RA CSB-BP011613RA CSB-MP011613RA CSB-EP011613RA-B |
Recombinant Rat Interleukin-1 alpha (Il1a) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
Code | Product Name | Source |
---|---|---|
CSB-YP011613DRI CSB-EP011613DRI CSB-BP011613DRI CSB-MP011613DRI CSB-EP011613DRI-B |
Recombinant Cercocebus atys Interleukin-1 alpha (IL1A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A Proteins for Ovis aries (Sheep)
Code | Product Name | Source |
---|---|---|
CSB-YP630687SH CSB-EP630687SH CSB-BP630687SH CSB-MP630687SH CSB-EP630687SH-B |
Recombinant Sheep Interleukin-1 alpha (IL1A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A Proteins for Equus caballus (Horse)
Code | Product Name | Source |
---|---|---|
CSB-YP636720HO CSB-EP636720HO CSB-BP636720HO CSB-MP636720HO CSB-EP636720HO-B |
Recombinant Horse Interleukin-1 alpha (IL1A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A Proteins for Bubalus carabanensis (Swamp type water buffalo) (Bubalus bubalis carabanensis)
Code | Product Name | Source |
---|---|---|
CSB-YP661675BAAW CSB-EP661675BAAW CSB-BP661675BAAW CSB-MP661675BAAW CSB-EP661675BAAW-B |
Recombinant Bubalus carabanensis Interleukin-1 alpha (IL1A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A Proteins for Cavia porcellus (Guinea pig)
Code | Product Name | Source |
---|---|---|
CSB-YP733672GU CSB-EP733672GU CSB-BP733672GU CSB-MP733672GU CSB-EP733672GU-B |
Recombinant Guinea pig Interleukin-1 alpha (IL1A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A Proteins for Lama glama (Llama)
Code | Product Name | Source |
---|---|---|
CSB-YP774725LBS CSB-EP774725LBS CSB-BP774725LBS CSB-MP774725LBS CSB-EP774725LBS-B |
Recombinant Lama glama Interleukin-1 alpha (IL1A) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1A ELISA Kit for Bos taurus (Bovine)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E12019B | Bovine Interleukin 1,IL-1 ELISA Kit | serum, plasma, tissue homogenates | 250 pg/mL |
IL1A ELISA Kit for Oryctolagus cuniculus (Rabbit)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E06896Rb | Rabbit Interleukin 1,IL-1 ELISA Kit | serum, plasma, tissue homogenates | 3.9 pg/mL |
IL1A ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04620h | Human Interleukin 1α,IL-1α ELISA Kit | serum, plasma, tissue homogenates, cell lysates, cell culture supernates. | 0.975 pg/ml. |
IL1A ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04621m | Mouse Interleukin 1α,IL-1α ELISA kit | serum, plasma, tissue homogenates | 0.58 pg/ml |
IL1A ELISA Kit for Sus scrofa (Pig)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E09725p | Pig Interleukin 1α,IL-1α ELISA kit | serum, plasma, cell culture supernates, tissue homogenates | 6.25 pg/mL |
IL1A ELISA Kit for Rattus norvegicus (Rat)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04622r | Rat Interleukin 1α,IL-1α ELISA kit | serum, plasma, tissue homogenates. | 19.5 pg/ml. |
IL1A ELISA Kit for Monkey
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E10041Mo | Monkey Interleukin-1 alpha (IL1A) ELISA kit | serum, plasma, tissue homogenates | 1.95 pg/mL |