Phospho-BCL2L1 (Ser62) Antibody

Datasheet
Code CSB-PA786016
Size US$360
Uniprot No. Q07817
Image
  • Immunofluorescence staining of methanol-fixed HeLa cells using BCL-XL (phospho-Ser62) antibody.

  • Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using BCL-XL (phospho-Ser62) antibody.

  • Western blot analysis of extracts from Hela cells untreated or treated with EGF using BCL-XL (Phospho-Ser62) Antibody.

  • Western blot analysis of extracts from Hela cells, treated with Noc or calf intestinal phosphatase (CIP), using BCL-XL (Phospho-Ser62) Antibody.

Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Raised in Rabbit
Species Reactivity Human, Mouse, Rat
Tested Applications ELISA, WB, IHC, IF; WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200
Form Liquid
Clonality Polyclonal
Alias BCLX, BCL2L, BCLXL, BCLXS,
Target Names BCL2L1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.; FUNCTION
Subcellular Location Isoform Bcl-X(L): Mitochondrion inner membrane, Mitochondrion outer membrane, Mitochondrion matrix, Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane, Cytoplasm, cytosol, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Nucleus membrane, Single-pass membrane protein, Cytoplasmic side
Protein Families Bcl-2 family
Tissue Specificity Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.
Database Links

HGNC: 992

OMIM: 600039

KEGG: hsa:598

STRING: 9606.ENSP00000302564

UniGene: Hs.516966

Pathway Jak-STAT signaling pathway
PI3K-Akt signaling pathway
NF-kappa B signaling pathway
Apoptosis
Autophagy
Ras signaling pathway
NOD-like receptor signaling pathway

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