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| Code | CSB-PA004811LA01HU |
| See More Details |  |
| Size | US$299 |
| Uniprot No. | P24385 |
| Immunogen | Recombinant Human G1/S-specific cyclin-D1 protein (1-295AA) |
| Raised in | Rabbit |
| Species Reactivity | Human |
| Tested Applications | ELISA |
| Relevance | Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner |
| Form | Liquid |
| Conjugate | Non-conjugated |
| Storage Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method | >95%, Protein G purified |
| Isotype | IgG |
| Clonality | Polyclonal |
| Alias | G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene), CCND1, BCL1 PRAD1 |
| Immunogen Species | Homo sapiens (Human) |
| Protocols | ELISA Protocol |
| Research Area | Cell Biology |
| Target Names | CCND1 |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. |
| Involvement in disease | Multiple myeloma (MM) |
| Subcellular Location | Nucleus, Cytoplasm, Membrane |
| Protein Families | Cyclin family, Cyclin D subfamily |
| Database Links |
HGNC: 1582 OMIM: 168461 KEGG: hsa:595 STRING: 9606.ENSP00000227507 UniGene: Hs.523852 |
| Pathway |
Hedgehog signaling pathway
Hippo signaling pathway Jak-STAT signaling pathway p53 signaling pathway PI3K-Akt signaling pathway Wnt signaling pathway Focal adhesion Cell cycle Cellular senescence AGE-RAGE signaling pathway in diabetic complications AMPK signaling Apelin signaling pathway FoxO signaling pathway |
CCND1 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA004811LD01HU | CCND1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA004811LC01HU | CCND1 Antibody, FITC conjugated | Human | ELISA |
| CSB-PA004811LB01HU | CCND1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA004811KA01HU | CCND1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,ICC,IP |
| CSB-PA184970 | Phospho-CCND1 (Thr286) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA963558 | Phospho-CCND1 (Ser90) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA000642 | Phospho-CCND1 (T286) Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA001875 | CCND1 Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA040188 | CCND1 Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA080258 | CCND1 Antibody | Rat,Mouse | WB,IHC |
| CSB-PA516472 | CCND1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA446984 | CCND1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA843257 | CCND1 Antibody | Human,Mouse,Rat | ELISA,IHC |
CCND1 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP004811HU CSB-BP004811HU CSB-MP004811HU |
Recombinant Human G1/S-specific cyclin-D1(CCND1) | Yeast Baculovirus Mammalian cell |
| CSB-EP004811HU | Recombinant Human G1/S-specific cyclin-D1(CCND1) | E.coli |
CCND1 ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E08286h | Human G1/S-specific Cyclin-D1 ELISA Kit | serum, plasma, cell culture supernates, cell lysates | 0.078 ng/mL |
2-hydroxyisobutyryl-HIST1H1C (K158) Antibody
Applications: ELISA, WB, ICC, ChIP
Species Reactivity: Human
2-hydroxyisobutyryl-HIST1H4A (K16) Antibody
Applications: ELISA, WB, IF, IP, ChIP
Species Reactivity: Human
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