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| Code | CSB-EP004811HU |
| Product Type | Recombinant Protein |
| Size | US$1675 |
| Uniprot No. | P24385 |
| Relevance | Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits mbers of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. |
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| Storage Buffer | Tris-based buffer,50% glycerol |
| Alias | B-cell lymphoma 1 protein ;BCL-1BCL-1 oncogene;PRAD1 oncogene |
| Species | Homo sapiens (Human) |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Sequence | MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRKHAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCDPDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI |
| Research Area | Cell Cycle |
| Source | E.coli |
| Gene Names | CCND1 |
| Expression Region | 1-295aa |
| Tag Info | N-terminal 6xHis-tagged |
| Mol. Weight | 37.7kDa |
| Protein Description | Full Length |
| Storage | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
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| Function | Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner. |
| Involvement in disease | Multiple myeloma (MM) |
| Subcellular Location | Nucleus, Cytoplasm, Membrane |
| Protein Families | Cyclin family, Cyclin D subfamily |
| Database Links |
HGNC: 1582 OMIM: 168461 KEGG: hsa:595 STRING: 9606.ENSP00000227507 UniGene: Hs.523852 |
| Pathway |
Hedgehog signaling pathway
Hippo signaling pathway Jak-STAT signaling pathway p53 signaling pathway PI3K-Akt signaling pathway Wnt signaling pathway Focal adhesion Cell cycle Cellular senescence AGE-RAGE signaling pathway in diabetic complications AMPK signaling Apelin signaling pathway FoxO signaling pathway |
CCND1 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA004811LD01HU | CCND1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA004811LC01HU | CCND1 Antibody, FITC conjugated | Human | ELISA |
| CSB-PA004811LB01HU | CCND1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA004811LA01HU | CCND1 Antibody | Human | ELISA |
| CSB-PA004811KA01HU | CCND1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC,ICC,IP |
| CSB-PA184970 | Phospho-CCND1 (Thr286) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA963558 | Phospho-CCND1 (Ser90) Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA000642 | Phospho-CCND1 (T286) Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA001875 | CCND1 Antibody | Human,Mouse,Rat | WB,IHC,ELISA |
| CSB-PA040188 | CCND1 Antibody | Human,Mouse,Rat | WB,ELISA |
| CSB-PA080258 | CCND1 Antibody | Rat,Mouse | WB,IHC |
| CSB-PA516472 | CCND1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA446984 | CCND1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA843257 | CCND1 Antibody | Human,Mouse,Rat | ELISA,IHC |
CCND1 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP004811HU CSB-BP004811HU CSB-MP004811HU |
Recombinant Human G1/S-specific cyclin-D1(CCND1) | Yeast Baculovirus Mammalian cell |
CCND1 ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-E08286h | Human G1/S-specific Cyclin-D1 ELISA Kit | serum, plasma, cell culture supernates, cell lysates | 0.078 ng/mL |
Recombinant Human E3 ubiquitin-protein ligase TRIM21(TRIM21)
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Human Transcription initiation factor IIA subunit 2(GTF2A2)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Cellular tumor antigen p53(TP53)
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Human Myc proto-oncogene protein(MYC),Escherichia Coli
Express system: E.coli
Species: Homo sapiens (Human)
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