CSF2 Antibody

Code CSB-PA268599
Size US$299
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA268599(CSF2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: RAW264.7 cells, Primary antibody: CSB-PA268599(CSF2 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes
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Product Details

Uniprot No. P04141
Target Names CSF2
Alternative Names Colony stimulating factor 2 (granulocyte-macrophage) antibody; Colony Stimulating Factor 2 antibody; Colony stimulating factor antibody; Colony-stimulating factor antibody; CSF 2 antibody; CSF antibody; CSF2 antibody; CSF2_HUMAN antibody; GM-CSF antibody; GMCSF antibody; Granulocyte Macrophage Colony Stimulating Factor antibody; Granulocyte-macrophage colony-stimulating factor antibody; MGC131935 antibody; MGC138897 antibody; MGI1GM antibody; Molgramostin antibody; Pluripoietin-a antibody; Sargramostim antibody
Raised in Rabbit
Species Reactivity Human,Mouse
Immunogen Fusion protein of Human CSF2
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method Antigen affinity purification
Concentration It differs from different batches. Please contact us to confirm it.
Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form Liquid
Tested Applications ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:2000
WB 1:200-1:1000
IHC 1:50-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
Gene References into Functions
  1. GM-CSF could be induced by M. pneumoniae infection in vivo and vitro. Childen with high level GM-CSF had longer duration of fever. GM-CSF probably plays a vital role in neutrophil inflammation in M. pneumoniae infection. PMID: 30007865
  2. Data show that CD4 T cells from synovial fluid are enriched for granulocyte-macrophage colony-stimulating factor (GM-CSF) production, suggests that the GM-CSF programme may be a primary pathogenic process. PMID: 29142230
  3. GM-CSF bioavailability plays a critical role in maintaining intestinal homeostasis. Decreased bioavailability coupled with the genetic risk markers and/or smoking results in aggressive ileal Crohn's disease behavior. PMID: 29434451
  4. Data show that GIF (ORF117 ) serves as a competitive decoy receptor by leveraging binding hotspots underlying the cognate receptor interactions of granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin-2 (IL-2). PMID: 27819269
  5. As translated to human disease, these findings suggest vaccine-mediated expansion of GM-CSF-producing T cells could be an effective prophylactic or therapeutic TB strategy. PMID: 29233902
  6. In a subset of patients who received GM-CSF, circulating myeloid-derived suppressor cells (MDSC), and anti-GM-CSF-neutralizing antibodies (Nabs) were also modulated. The majority of patients developed anti-GM-CSF Nabs, which correlated with improved RFS and OS PMID: 28536308
  7. this study shows that cortisol inhibits CSF2 via DNA methylation and inhibits invasion in first-trimester trophoblast cells PMID: 28846166
  8. Oral and periodontal innate immunity is affected by HIV viremia and ART. GCF IL-8, G-CSF, as well as serum IL-8, MCP-1 and GM-CSF may be useful biomarkers for the detection of disease presence and/or its severity due to HIV infection and ART use. PMID: 28043030
  9. This review summarizes a number of findings to provide the currently available information regarding the anticancer immune response of GM-CSG. [review] PMID: 27364892
  10. Data suggest that the intratumoral GM-CSF expression, as a potentially independent prognostic biomarker for recurrence, might improve conventional clinical and pathologic analysis to refine outcome prediction for clinically localized clear-cell renal cell carcinoma (ccRCC) patients after surgery. PMID: 27016418
  11. High GM-CSF expression is associated with breast Cancer. PMID: 28754674
  12. In gastric cancer (GC), tumour-derived GM-CSF activated neutrophils and induced neutrophil PD-L1 expression via Janus kinase (JAK)-signal transducer and activator of transcription 3 (STAT3) signalling pathway. The activated PD-L1(+) neutrophils effectively suppressed normal T-cell immunity in vitro and contributed to the growth and progression of human GC in vivo. PMID: 28274999
  13. The IL-3/ GM-CSF effected on the myofibroblastic differentiation of human adipose derive stromal cells (hASCs) as well as it did on human dermal fibroblasts (HDFs). PMID: 28377320
  14. Obesity alters the lung neutrophil infiltration to enhance breast cancer metastasis through IL5 and GM-CSF. PMID: 28737771
  15. Data suggest that the methylotrophic yeast Pichia pastoris is an effective recombinant host for heterologous granulocyte-macrophage colony-stimulating factor (rhGM-CSF) production. PMID: 28376863
  16. Letter: Knockdown of either filaggrin or loricrin increases the productions of interleukin (IL)-1alpha, IL-8, IL-18 and granulocyte macrophage colony-stimulating factor in stratified human keratinocytes. PMID: 26381575
  17. Impaired RASGRF1/ERK-mediated GM-CSF response characterizes CARD9 deficiency in French-Canadians. PMID: 26521038
  18. Honokiol could possess potential anti-inflammatory effects and inhibits TNF-alpha-induced IL-1beta, GM-CSF and IL-8 production in PBMCs from rheumatoid arthritis patients. PMID: 26339358
  19. The canonical NFkappaB signaling in fibroblasts, but not in tumor cells, was shown to be responsible for the induced and constitutive CSF2 expression. PMID: 25919140
  20. GM-CSF primes IL-13 production by macrophages via PAR-2. PMID: 25633855
  21. analysis of an IL2RA polymorphism that controls GM-CSF production in human TH cells PMID: 25278028
  22. NFKBIZ gene knockdown in bronchial epithelial cells suppresses the release of IL-1b-induced IL-6 and GMCSF. PMID: 25629767
  23. CFH Y402H polymorphism is associated with elevated vitreal GM-CSF and choroidal macrophages in the postmortem human eye. PMID: 25814824
  24. Influenza infection stimulates the secretion of IL-8 and GM-CSF by alveolar epithelial cells. PMID: 26033355
  25. Periodic fever, aphthous stomatitis, pharyngitis and cervical adenopathy syndrome febrile episodes are characterized by activation of GM-CSF and IL-8 with Th1 skewing. PMID: 24670131
  26. activation of STAT3 induces the expression of GM-CSFRa that protects CLL cells from apoptosis, suggesting that inhibition of STAT3 or GM-CSFRa may benefit patients with chronic lymphocytic leukemia PMID: 24836891
  27. G-CSF- or GM-CSF-secreting cancers, albeit not very common are, however, among the most rapidly advancing ones due to a cytokine-mediated immune suppression and angiogenesis. [Review] PMID: 24692240
  28. Treatment with GM-CSF increased the expression of vimentin and ZEB1, similar to TGF-b1 treatment, and decreased the expression of E-cadherin. Our results suggest that GM-CSF could induce EMT in human HERS/ERM cells. PMID: 24258001
  29. GM-CSF polymorphism may be involved in the pathogenesis of atopic dermatitis. PMID: 24117406
  30. The association of GM-CSF expression with systemic inflammation highlights the potential role of Th17-related cytokines in the pathology of juvenile idiopathic arthritis. PMID: 24692225
  31. M-CSF induces macrophage transformation by upregulating c-Jun with a certain synergy of NFkappaB. PMID: 24100343
  32. The detection of basal level of IgM rheumatoid factor, IgM and also certain cytokines can be useful in prognosis of effectiveness of rituximab therapy under rheumatoid arthritis. PMID: 25080789
  33. Cytokines and signaling molecules predict clinical outcomes in sepsis. PMID: 24244449
  34. Granulocyte colony-stimulating factor produces long-term changes in gene and microRNA expression profiles in CD34+ cells from healthy donors. PMID: 24056818
  35. mesenchymal-like breast cancer cells activate macrophages to a tumor-associated macrophage-like phenotype by GM-CSF. PMID: 24823638
  36. The comparison between the cytokine profiles of ET and PV patients showed a statistically significant increase of IL-4, IL-8, GM-CSF, interferon -gamma, MCP-1, PDGF-BB, and VEGF in the ET group PMID: 24463275
  37. Data indicate that differentially expressed IL-17, IL-22, and IL-23 levels are associated with K-ras in a stage-specific fashion along colorectal cancer progression and an association was established between mutant K-ras and GM-CSF and IFN-gamma. PMID: 24040001
  38. in the type 2 diabetes mellitus group, significantly higher IL-4 level on the first and the third post dengue virus infection days, while higher IL-10 and granulocyte-macrophage colony-stimulating factor were detected on the third postinfection day. PMID: 24078930
  39. loss of BMPR2 induced prolonged phospho-p38 MAPK in response to TNF, and this increased GADD34-PP1 phosphatase activity, dephosphorylating eukaryotic translation initiation factor (eIF2alpha), and derepressing GM-CSF mRNA translation PMID: 24446489
  40. Since GM-CSF plays an important role during pregnancy, the reduced levels of GM-CSF in the cervico-vaginal fluid of human papillomavirus(+) women might contribute to explain the reduced live birth rate. PMID: 23920355
  41. SECTM1 secreted from bone marrow stromal cells may interact with CD7 to influence GM-CSF expression in leukemic cells. PMID: 24211252
  42. Describe GM-CSF ELISA for routine clinical diagnosis of autoimmune pulmonary alveolar proteinosis. PMID: 24275678
  43. The data presented suggest that -677C/A in the promoter region of the GM-CSF gene does not play a role in acne pathogenesis. PMID: 23069312
  44. CBL linker and RING finger mutants lead to enhanced GM-CSF signaling due to elevated kinase expression, which can be blocked using small molecule inhibitors targeting specific downstream pathways. PMID: 23696637
  45. impairment of NFATC2-calcineurin interaction promotes megakaryocyte proliferation through up-regulation of CSF2 transcription PMID: 22911897
  46. Overexpression of a nonphosphorylatable MT1-MMP mutant (Y573F) abrogates CSF-2 and CSF-3 transcriptional increases. PMID: 23548906
  47. GM-CSF contributes to aortic aneurysms resulting from SMAD3 deficiency PMID: 23585475
  48. Within pediatric Crohn disease, neutrophil GM-CSF-dependent STAT5 activation and bacterial killing were reduced as GM-CSF autoantibodies increased. PMID: 23600834
  49. This study demonistrated that GMCSF is downregulation in brain in patient with Alzheimer's disease. PMID: 22430742
  50. IL-27 suppresss GM-CSF production under nonpolarizing and T helper (Th)1 cell, but not T helper (Th)17 cell conditions, in both murine and human cultures. PMID: 22837488

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Subcellular Location Secreted.
Protein Families GM-CSF family
Database Links

HGNC: 2434

OMIM: 138960

KEGG: hsa:1437

STRING: 9606.ENSP00000296871

UniGene: Hs.1349

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