CSF2

CSF2, or Colony Stimulating Factor 2, alias Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF). It is a cytokine secreted by a variety of cell types, such as macrophages, T cells, mast cells, natural killer cells, endothelial cells and fibroblasts.The primary role of CSF2 is to promote the proliferation and differentiation of myeloid haematopoietic progenitor cells, with particular effects on the granulocyte and macrophage lineages. It promotes cell proliferation, differentiation and maturation by activating the JAK/STAT signalling pathway through binding to its specific receptor.

CSF2 is biologically important and is essential for the development and function of the immune system.CSF2 is involved in the regulation of inflammatory responses, the promotion of tissue repair and wound healing, and also plays a role in the pathogenesis of certain diseases, such as rheumatoid arthritis. In addition, aberrant expression or dysfunction of CSF2 has been linked to a variety of diseases, including certain types of cancer and autoimmune diseases. In the tumour microenvironment, CSF2 may also influence the behaviour of tumour cells, including proliferation, invasion and metastasis.