CSF2, or Colony Stimulating Factor 2, alias Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF). It is a cytokine secreted by a variety of cell types, such as macrophages, T cells, mast cells, natural killer cells, endothelial cells and fibroblasts.The primary role of CSF2 is to promote the proliferation and differentiation of myeloid haematopoietic progenitor cells, with particular effects on the granulocyte and macrophage lineages. It promotes cell proliferation, differentiation and maturation by activating the JAK/STAT signalling pathway through binding to its specific receptor.
CSF2 is biologically important and is essential for the development and function of the immune system.CSF2 is involved in the regulation of inflammatory responses, the promotion of tissue repair and wound healing, and also plays a role in the pathogenesis of certain diseases, such as rheumatoid arthritis. In addition, aberrant expression or dysfunction of CSF2 has been linked to a variety of diseases, including certain types of cancer and autoimmune diseases. In the tumour microenvironment, CSF2 may also influence the behaviour of tumour cells, including proliferation, invasion and metastasis.
Recombinant Human Granulocyte-macrophage colony-stimulating factor (CSF2) (Active) (CSB-MP006045HU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is 28.1-63.8 pg/mL.
The purity of CSF2 was greater than 90% as determined by SEC-HPLC
The following CSF2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
CSF2 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA006043GA01HU | CSF2 Antibody | Human | ELISA,WB |
CSB-PA06475A0Rb | CSF2 Antibody | Human | ELISA, IHC |
CSB-PA06475B0Rb | CSF2 Antibody, HRP conjugated | Human | ELISA |
CSB-PA06475C0Rb | CSF2 Antibody, FITC conjugated | Human | |
CSB-PA06475D0Rb | CSF2 Antibody, Biotin conjugated | Human | ELISA |
CSB-PA006045GA01HU | CSF2 Antibody | Human | ELISA,WB,IHC |
CSB-PA573559 | CSF2 Antibody | Human,Mouse | ELISA,WB |
CSB-PA268599 | CSF2 Antibody | Human,Mouse | ELISA,WB,IHC |
CSF2 Antibodies for Mus musculus (Mouse)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA006045XA01MO | Csf2 Antibody | Mus musculus (Mouse) | ELISA, WB (ensure identification of antigen) |
CSF2 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-EP006045BO CSB-BP006045BO CSB-MP006045BO CSB-EP006045BO-B |
Recombinant Bovine Granulocyte-macrophage colony-stimulating factor (CSF2) | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-YP006045BO | Recombinant Bovine Granulocyte-macrophage colony-stimulating factor (CSF2) | Yeast |
CSF2 Proteins for Ovis aries (Sheep)
Code | Product Name | Source |
---|---|---|
CSB-YP006045SH CSB-EP006045SH CSB-BP006045SH CSB-MP006045SH CSB-EP006045SH-B |
Recombinant Sheep Granulocyte-macrophage colony-stimulating factor (CSF2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSF2 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP006045RA CSB-EP006045RA CSB-BP006045RA CSB-MP006045RA CSB-EP006045RA-B |
Recombinant Rat Granulocyte-macrophage colony-stimulating factor (Csf2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSF2 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
Code | Product Name | Source |
---|---|---|
CSB-YP006045DO CSB-EP006045DO CSB-BP006045DO CSB-MP006045DO CSB-EP006045DO-B |
Recombinant Dog Granulocyte-macrophage colony-stimulating factor (CSF2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSF2 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-BP006045MO CSB-MP006045MO CSB-EP006045MO-B |
Recombinant Mouse Granulocyte-macrophage colony-stimulating factor (Csf2) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-AP003441MO | Recombinant Mouse Granulocyte-macrophage colony-stimulating factor protein (Csf2) (Active) | E.coli |
CSB-AP003651MO | Recombinant Mouse Granulocyte-macrophage colony-stimulating factor (Csf2) (Active) | Mammalian cell |
CSB-AP003661MO | Recombinant Mouse Granulocyte-macrophage colony-stimulating factor (Csf2) (Active) | E.coli |
CSF2 Proteins for Felis catus (Cat) (Felis silvestris catus)
Code | Product Name | Source |
---|---|---|
CSB-YP006045CA CSB-EP006045CA CSB-BP006045CA CSB-MP006045CA CSB-EP006045CA-B |
Recombinant Cat Granulocyte-macrophage colony-stimulating factor (CSF2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSF2 Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
Code | Product Name | Source |
---|---|---|
CSB-YP611263DSU CSB-EP611263DSU CSB-BP611263DSU CSB-MP611263DSU CSB-EP611263DSU-B |
Recombinant Chlorocebus aethiops Granulocyte-macrophage colony-stimulating factor (CSF2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSF2 Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP639041PI CSB-EP639041PI CSB-BP639041PI CSB-MP639041PI CSB-EP639041PI-B |
Recombinant Pig Granulocyte-macrophage colony-stimulating factor (CSF2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSF2 Proteins for Cavia porcellus (Guinea pig)
Code | Product Name | Source |
---|---|---|
CSB-YP717096GU CSB-EP717096GU CSB-BP717096GU CSB-MP717096GU CSB-EP717096GU-B |
Recombinant Guinea pig Granulocyte-macrophage colony-stimulating factor (CSF2) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSF2 Proteins for Homo sapiens (Human)
CSF2 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04568h | Human Granulocyte-Macrophage Colony Stimulating Factor,GM-CSF ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 3.9 pg/mL |
CSF2 ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04569m | Mouse Granulocyte-Macrophage Colony Stimulating Factor,GM-CSF ELISA Kit | serum, plasma, tissue homogenates | 3.9 pg/mL |
CSF2 ELISA Kit for Rattus norvegicus (Rat)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04570r | Rat Granulocyte-Macrophage Colony Stimulating Factor,GM-CSF ELISA Kit | serum, plasma, tissue homogenates | 3.9 pg/ml |
CSB-E07340r | Rat Granulocyte Colony Stimulating Factor,G-CSF ELISA Kit | serum, plasma, cell culture supernates, tissue homogenates | 7.81 pg/mL |