CSF2 Antibody, HRP conjugated

Code CSB-PA06475B0Rb
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) CSF2 Polyclonal antibody
Uniprot No. P04141
Target Names CSF2
Alternative Names Colony stimulating factor 2 (granulocyte-macrophage) antibody; Colony Stimulating Factor 2 antibody; Colony stimulating factor antibody; Colony-stimulating factor antibody; CSF 2 antibody; CSF antibody; CSF2 antibody; CSF2_HUMAN antibody; GM-CSF antibody; GMCSF antibody; Granulocyte Macrophage Colony Stimulating Factor antibody; Granulocyte-macrophage colony-stimulating factor antibody; MGC131935 antibody; MGC138897 antibody; MGI1GM antibody; Molgramostin antibody; Pluripoietin-a antibody; Sargramostim antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Granulocyte-macrophage colony-stimulating factor protein (18-144AA)
Immunogen Species Homo sapiens (Human)
Conjugate HRP
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
Gene References into Functions
  1. GM-CSF could be induced by M. pneumoniae infection in vivo and vitro. Childen with high level GM-CSF had longer duration of fever. GM-CSF probably plays a vital role in neutrophil inflammation in M. pneumoniae infection. PMID: 30007865
  2. Data show that CD4 T cells from synovial fluid are enriched for granulocyte-macrophage colony-stimulating factor (GM-CSF) production, suggests that the GM-CSF programme may be a primary pathogenic process. PMID: 29142230
  3. GM-CSF bioavailability plays a critical role in maintaining intestinal homeostasis. Decreased bioavailability coupled with the genetic risk markers and/or smoking results in aggressive ileal Crohn's disease behavior. PMID: 29434451
  4. Data show that GIF (ORF117 ) serves as a competitive decoy receptor by leveraging binding hotspots underlying the cognate receptor interactions of granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin-2 (IL-2). PMID: 27819269
  5. As translated to human disease, these findings suggest vaccine-mediated expansion of GM-CSF-producing T cells could be an effective prophylactic or therapeutic TB strategy. PMID: 29233902
  6. In a subset of patients who received GM-CSF, circulating myeloid-derived suppressor cells (MDSC), and anti-GM-CSF-neutralizing antibodies (Nabs) were also modulated. The majority of patients developed anti-GM-CSF Nabs, which correlated with improved RFS and OS PMID: 28536308
  7. this study shows that cortisol inhibits CSF2 via DNA methylation and inhibits invasion in first-trimester trophoblast cells PMID: 28846166
  8. Oral and periodontal innate immunity is affected by HIV viremia and ART. GCF IL-8, G-CSF, as well as serum IL-8, MCP-1 and GM-CSF may be useful biomarkers for the detection of disease presence and/or its severity due to HIV infection and ART use. PMID: 28043030
  9. This review summarizes a number of findings to provide the currently available information regarding the anticancer immune response of GM-CSG. [review] PMID: 27364892
  10. Data suggest that the intratumoral GM-CSF expression, as a potentially independent prognostic biomarker for recurrence, might improve conventional clinical and pathologic analysis to refine outcome prediction for clinically localized clear-cell renal cell carcinoma (ccRCC) patients after surgery. PMID: 27016418
  11. High GM-CSF expression is associated with breast Cancer. PMID: 28754674
  12. In gastric cancer (GC), tumour-derived GM-CSF activated neutrophils and induced neutrophil PD-L1 expression via Janus kinase (JAK)-signal transducer and activator of transcription 3 (STAT3) signalling pathway. The activated PD-L1(+) neutrophils effectively suppressed normal T-cell immunity in vitro and contributed to the growth and progression of human GC in vivo. PMID: 28274999
  13. The IL-3/ GM-CSF effected on the myofibroblastic differentiation of human adipose derive stromal cells (hASCs) as well as it did on human dermal fibroblasts (HDFs). PMID: 28377320
  14. Obesity alters the lung neutrophil infiltration to enhance breast cancer metastasis through IL5 and GM-CSF. PMID: 28737771
  15. Data suggest that the methylotrophic yeast Pichia pastoris is an effective recombinant host for heterologous granulocyte-macrophage colony-stimulating factor (rhGM-CSF) production. PMID: 28376863
  16. Letter: Knockdown of either filaggrin or loricrin increases the productions of interleukin (IL)-1alpha, IL-8, IL-18 and granulocyte macrophage colony-stimulating factor in stratified human keratinocytes. PMID: 26381575
  17. Impaired RASGRF1/ERK-mediated GM-CSF response characterizes CARD9 deficiency in French-Canadians. PMID: 26521038
  18. Honokiol could possess potential anti-inflammatory effects and inhibits TNF-alpha-induced IL-1beta, GM-CSF and IL-8 production in PBMCs from rheumatoid arthritis patients. PMID: 26339358
  19. The canonical NFkappaB signaling in fibroblasts, but not in tumor cells, was shown to be responsible for the induced and constitutive CSF2 expression. PMID: 25919140
  20. GM-CSF primes IL-13 production by macrophages via PAR-2. PMID: 25633855
  21. analysis of an IL2RA polymorphism that controls GM-CSF production in human TH cells PMID: 25278028
  22. NFKBIZ gene knockdown in bronchial epithelial cells suppresses the release of IL-1b-induced IL-6 and GMCSF. PMID: 25629767
  23. CFH Y402H polymorphism is associated with elevated vitreal GM-CSF and choroidal macrophages in the postmortem human eye. PMID: 25814824
  24. Influenza infection stimulates the secretion of IL-8 and GM-CSF by alveolar epithelial cells. PMID: 26033355
  25. Periodic fever, aphthous stomatitis, pharyngitis and cervical adenopathy syndrome febrile episodes are characterized by activation of GM-CSF and IL-8 with Th1 skewing. PMID: 24670131
  26. activation of STAT3 induces the expression of GM-CSFRa that protects CLL cells from apoptosis, suggesting that inhibition of STAT3 or GM-CSFRa may benefit patients with chronic lymphocytic leukemia PMID: 24836891
  27. G-CSF- or GM-CSF-secreting cancers, albeit not very common are, however, among the most rapidly advancing ones due to a cytokine-mediated immune suppression and angiogenesis. [Review] PMID: 24692240
  28. Treatment with GM-CSF increased the expression of vimentin and ZEB1, similar to TGF-b1 treatment, and decreased the expression of E-cadherin. Our results suggest that GM-CSF could induce EMT in human HERS/ERM cells. PMID: 24258001
  29. GM-CSF polymorphism may be involved in the pathogenesis of atopic dermatitis. PMID: 24117406
  30. The association of GM-CSF expression with systemic inflammation highlights the potential role of Th17-related cytokines in the pathology of juvenile idiopathic arthritis. PMID: 24692225
  31. M-CSF induces macrophage transformation by upregulating c-Jun with a certain synergy of NFkappaB. PMID: 24100343
  32. The detection of basal level of IgM rheumatoid factor, IgM and also certain cytokines can be useful in prognosis of effectiveness of rituximab therapy under rheumatoid arthritis. PMID: 25080789
  33. Cytokines and signaling molecules predict clinical outcomes in sepsis. PMID: 24244449
  34. Granulocyte colony-stimulating factor produces long-term changes in gene and microRNA expression profiles in CD34+ cells from healthy donors. PMID: 24056818
  35. mesenchymal-like breast cancer cells activate macrophages to a tumor-associated macrophage-like phenotype by GM-CSF. PMID: 24823638
  36. The comparison between the cytokine profiles of ET and PV patients showed a statistically significant increase of IL-4, IL-8, GM-CSF, interferon -gamma, MCP-1, PDGF-BB, and VEGF in the ET group PMID: 24463275
  37. Data indicate that differentially expressed IL-17, IL-22, and IL-23 levels are associated with K-ras in a stage-specific fashion along colorectal cancer progression and an association was established between mutant K-ras and GM-CSF and IFN-gamma. PMID: 24040001
  38. in the type 2 diabetes mellitus group, significantly higher IL-4 level on the first and the third post dengue virus infection days, while higher IL-10 and granulocyte-macrophage colony-stimulating factor were detected on the third postinfection day. PMID: 24078930
  39. loss of BMPR2 induced prolonged phospho-p38 MAPK in response to TNF, and this increased GADD34-PP1 phosphatase activity, dephosphorylating eukaryotic translation initiation factor (eIF2alpha), and derepressing GM-CSF mRNA translation PMID: 24446489
  40. Since GM-CSF plays an important role during pregnancy, the reduced levels of GM-CSF in the cervico-vaginal fluid of human papillomavirus(+) women might contribute to explain the reduced live birth rate. PMID: 23920355
  41. SECTM1 secreted from bone marrow stromal cells may interact with CD7 to influence GM-CSF expression in leukemic cells. PMID: 24211252
  42. Describe GM-CSF ELISA for routine clinical diagnosis of autoimmune pulmonary alveolar proteinosis. PMID: 24275678
  43. The data presented suggest that -677C/A in the promoter region of the GM-CSF gene does not play a role in acne pathogenesis. PMID: 23069312
  44. CBL linker and RING finger mutants lead to enhanced GM-CSF signaling due to elevated kinase expression, which can be blocked using small molecule inhibitors targeting specific downstream pathways. PMID: 23696637
  45. impairment of NFATC2-calcineurin interaction promotes megakaryocyte proliferation through up-regulation of CSF2 transcription PMID: 22911897
  46. Overexpression of a nonphosphorylatable MT1-MMP mutant (Y573F) abrogates CSF-2 and CSF-3 transcriptional increases. PMID: 23548906
  47. GM-CSF contributes to aortic aneurysms resulting from SMAD3 deficiency PMID: 23585475
  48. Within pediatric Crohn disease, neutrophil GM-CSF-dependent STAT5 activation and bacterial killing were reduced as GM-CSF autoantibodies increased. PMID: 23600834
  49. This study demonistrated that GMCSF is downregulation in brain in patient with Alzheimer's disease. PMID: 22430742
  50. IL-27 suppresss GM-CSF production under nonpolarizing and T helper (Th)1 cell, but not T helper (Th)17 cell conditions, in both murine and human cultures. PMID: 22837488
  51. Data show that pancreatic ductal adenocarcinoma (PDA) tumor cells prominently expressed GM-CSF in vivo. PMID: 22698406
  52. Data indicate that an enhanced GM-CSF production was observed in pancreatic intraepithelial neoplasia (PanIN) lesions. PMID: 22698407
  53. The expression of granulocyte-macrophage colony-stimulating factor (GM-CSF) and its receptors (GM-CSF.R) in 20 human brain gliomas with different tumor gradings, were studied. PMID: 22200506
  54. Data indicate that infection may disturb both GM-CSF-dependent physiologic processes and suggest GM-CSF-based therapeutic approaches. PMID: 22031867
  55. Results provide evidence that TNF-alpha is an excellent readout of vaccinia specificity and that other cytokines such as GM-CSF can be used to evaluate the reactivity of CD4+ T cells in response to vaccinia antigens. PMID: 21931646
  56. Differences in protein expression induced by TNFalpha were limited and did not show discriminatory power in a principal component analysis, whereas the profile induced by GM-CSF did PMID: 21873076
  57. Monocytes differentiated with GM-CSF and IL-15 initiate Th17 and Th1 responses that are contact-dependent and mediated by IL-15. PMID: 21724805
  58. Potential paracrine interactions between human primary eosinophils and glioblastoma cells focus on the cytokine GM-CSF, which may play a functional role in certain tumor immune responses. PMID: 21705618
  59. Zymosan-induced GM-CSF-mediated signaling network may play a key role in regulating specific immune cell type activities. PMID: 21486701
  60. The levels of EPO, SCF and GM-CSF in chronic aplastic anemia patients were obviously lower than those in the healthy individuals. PMID: 18928604
  61. Results suggest that the 3CLpro may suppress expression of GM-CSF in transfected A549 cells through down-regulation of NF-kB production. PMID: 21324206
  62. Data indicate a role for PLCgamma2 and Ca(2+) signaling through the modulation of MEK/ERK in IL3/GM-csf stimulated human hematopoietic stem/progenitor cells. PMID: 21506110
  63. IgE and GM-CSF may contribute to the recruitment of eosinophils in nasal polyps. PMID: 18254319
  64. These findings suggest that human cytomegalovirus induces haemangiogenesis and lymphangiogenesis through an indirect mechanism that relies on the stimulation of IL-6 and GM-CSF secretion from infected cells. PMID: 21123547
  65. Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung. PMID: 21262803
  66. Results suggest that granulocyte-macrophage colony-stimulating factor plays a crucial role in the pathogenesis of preeclampsia. PMID: 20829438
  67. These results suggest that matrix metalloproteinases could be potentially involved in the tissue damage observed in osteoarticular brucellosis. PMID: 20956574
  68. These preliminary data might suggest an influence of cPLA2alpha on GM-CSF gene expression in human lung cells. PMID: 20802406
  69. Computer modelling predicted that the palindromic element is able to accommodate binding of two Runx1/core binding factor beta complexes closely aligned on the same face of the DNA helix. PMID: 20483917
  70. Higher mRNA expression of CSF2 were detected in gingival tissue from chronic periodontitis patients compared to healthy controls. PMID: 20233331
  71. GM-CSF may serve as a link between a pathologic inflammatory environment, pDC activation, and the modulation of CD4 T-cell responses PMID: 20382843
  72. GM-CSF contributes to the pathogenesis of RA through upregulation of NGAL in neutrophils, followed by induction of TERA, cathepsin D and TG2 in synoviocytes. NGAL and the upregulated enzymes may therefore play an important role in RA. PMID: 20527084
  73. Data show that Deletion of the Ig-like domain of GM-CSFRalpha abolished direct GM-CSF binding and decreased growth signalling in the presence of hbetac. PMID: 20078425
  74. results clearly identified a TLR2/6-dependent induction of angiogenesis by the bacterial lipopeptide MALP-2, which is mediated by GM-CSF PMID: 20056792
  75. PKC(alpha) and PKC(epsilon) differentially regulate Legionella pneumophila-induced GM-CSF PMID: 19324950
  76. GM-CSF is expressed in normal and glaucomatous human retina. PMID: 19560459
  77. The intronic CSF2_27348 A allele in chromosome 5q31 was associated with dose dependent protection from trichiasis, with each copy of the allele reducing risk by 37% (p = 0.005). PMID: 20015396
  78. Higher plasma endogenous GM-CSF level is found in stroke patients compared to controls PMID: 19807655
  79. inhibition of signaling by antisense oligodeoxynucleotides targeting the common beta chain of receptors PMID: 11763346
  80. GM-CSF-driven apoptosis, but not TNF-driven apoptosis was reversibly associated with bcl-2-expression (bcl-2-dependent mechanism)in acute lymphoblastic leukaemia and non-Hodgkin's lymphoma in children. PMID: 11855781
  81. Protection of peritoneal macrophages by granulocyte/macrophage colony-stimulating factor (GM-CSF) against dexamethasone suppression of killing of Aspergillus, and the effect of human GM-CSF. PMID: 11880043
  82. Adenomyotic glandular epithelium had greater expression of the GM-CSF ligand compared with autologous endometrium from premenopausal women PMID: 11963838
  83. Activated eosinophils release small amounts of anti-apoptotic GM-CSF by stabilizing its coding mRNA. Review. PMID: 12022701
  84. secretion from acute myelogenous leukemia blasts was up-regulated by leptin PMID: 12031914
  85. B-CLL patients with progressive disease had a significantly increased number of T cells spontaneously producing IL-2, IL-4 and GM-CSF, suggesting a role for T cells in the pathogenesis of B-CLL. PMID: 12144536
  86. GM-CSF induced human myelopoiesis is regulated by transforming growth factor-beta isoforms PMID: 12171249
  87. GMCSF is induced in bronchial epithelial cells by the MAP kinase signaling system in response to air pollutants PMID: 12356579
  88. GM-CSF plays a critical role in lung homeostasis by regulating levels of MCSF, MCP-1 and IL-8. PMID: 12356582
  89. Enhanced PMN survival was attributed to effects of epithelial G-CSF and granulocyte-macrophage colony-stimulating factor expression, which inhibit PMN apoptosis.Both CF and normal cells responded to bacteria with increased cytokine production PMID: 12397015
  90. data indicate that granulocyte-macrophage colony stimulating factor regulates cell viability in human embryos PMID: 12444058
  91. GM-CSF inhibits prolonged glucocorticoid-induced activation of eosinophil c-Jun NH2-terminal kinase and preserves the expression of eosinophil antiapoptotic protein X-linked inhibitor of apoptosis. PMID: 12496443
  92. signals for increased glucose transport via phosphatidylinositol 3-kinase- and hydrogen peroxide-dependent mechanisms PMID: 12538575
  93. Granulocyte-macrophage colony-stimulating factor inhibited the platelet-activating factor acetylhydrolase secretion by decidual macrophages PMID: 12548211
  94. GM-CSF-mediated antiapoptosis is mediated through protein synthesis-independent mechanisms and involves the Janus kinase-STAT pathway. PMID: 12568301
  95. IL-6 and GM-CSF may be involved in the autoimmune mechanism of non-segmental vitiligo. PMID: 12615367
  96. functional studies demonstrated GMCSF-dependent activation of IkappaB kinase activity in endothelial cells, degradation of IkappaB, and activation of NF-kappaB PMID: 12637324
  97. GM-CSF is up-regulated by ETS2, a target of protein kinase C PMID: 12646185
  98. GM-CSF exerts a dual effect: it stimulates cell division but contemporaneously up-regulates Jak-Stat-dependent proapoptotic proteins. PMID: 12663443
  99. ICAM-3 is highly expressed on the surface of human eosinophils and has a role in the downregulation of GM-CSF production. PMID: 12743567
  100. GMCSF is induced in lung fibroblasts by IL-beta, TNF-alpha, and macrophage contact. PMID: 12744771

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Subcellular Location Secreted
Protein Families GM-CSF family
Database Links

HGNC: 2434

OMIM: 138960

KEGG: hsa:1437

STRING: 9606.ENSP00000296871

UniGene: Hs.1349

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