Recombinant Human Granulocyte-macrophage colony-stimulating factor protein(CSF2) (Active)

In Stock
Code CSB-AP002081HU
Product Type Colony Stimulating Factor
Size US$112Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. P04141
Lead Time 5-10 business days
Image
Storage Buffer 0.2 μm filtered PBS, pH 7.4 ,lyophilized
Alias GM-CSF, CSF, Molgramostin, Sargramostim
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human TF-1 cells is less than 0.1 ng/ml, corresponding to a specific activity of >1.0x107 IU/mg.
Purity >98% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence APARSPSPST QPWEHVNAIQ EARRLLNLSR DTAAEMNETV EVISEMFDLQ EPTCLQTRLE LYKQGLRGSL TKLKGPLTMM ASHYKQHCPP TPETSCATQI ITFESFKENL KDFLLVIPFD CWEPVQE
Research Area Immunology
Source E.coli
Gene Names CSF2
Expression Region 18-144aa
Tag Info Tag-Free
Mol. Weight 14.5 kDa
Protein Description Full Length of Mature Protein
PubMed ID 3925454; 3486413; 3898082; 3923623; 3876930; 15372022; 15489334; 1737041; 1837174; 1569568; 18692472
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Function Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
Subcellular Location Secreted
Protein Families GM-CSF family
Database Links

HGNC: 2434

OMIM: 138960

KEGG: hsa:1437

STRING: 9606.ENSP00000296871

UniGene: Hs.1349

Pathway Jak-STAT signaling pathway
TNF signaling pathway
Fc epsilon RI signaling pathway
Hematopoietic cell lineage
IL-17 signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway

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