MMP2 Antibody

Datasheet
Code CSB-PA06879A0Rb
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
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  • Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA06879A0Rb at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA06879A0Rb at dilution of 1:100

  • Immunofluorescent analysis of Hela cells using CSB-PA06879A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) MMP2 Polyclonal antibody
Uniprot No. P08253
Target Names MMP2
Alternative Names 72 kDa gelatinase antibody; 72kD type IV collagenase antibody; CLG 4 antibody; CLG 4A antibody; CLG4 antibody; CLG4A antibody; Collagenase Type 4 alpha antibody; Collagenase type IV A antibody; Gelatinase A antibody; Gelatinase alpha antibody; Gelatinase neutrophil antibody; Matrix metallopeptidase 2 gelatinase A 72kDa gelatinase 72kDa type IV collagenase antibody; Matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) antibody; Matrix Metalloproteinase 2 antibody; Matrix metalloproteinase II antibody; Matrix metalloproteinase-2 antibody; MMP 2 antibody; MMP II antibody; MMP-2 antibody; MMP2 antibody; MMP2_HUMAN antibody; MONA antibody; Neutrophil gelatinase antibody; PEX antibody; TBE 1 antibody; TBE-1 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human 72 kDa type IV collagenase protein (445-660AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.; FUNCTION
Gene References into Functions
  1. No significant associations were observed with either MMP-2(-1306) C/T or MMP-3(-1171) 5A/6A. PMID: 30117779
  2. PROK1 or MMP-2 in the amniotic fluid do not have a role in the prediction of adverse pregnancy outcomes. PMID: 29405963
  3. CDH17 has a role in altering MMP-2 expression via canonical NF-kappaB signalling in human gastric cancer PMID: 29783070
  4. Study results revealed that CCR2 promotes epithelialtomesenchymal transition through MMP2 in liver cancer. PMID: 30132565
  5. results of the study indicate that estradiol influence MMP-2 expression in the endometrium depends on the phase of menstrual cycle PMID: 30187906
  6. Fewer TIMP-2, Hsp70 and TGF-beta1 immunoreactive cells in younger individuals and increased expression of Hsp70 in elderly individuals demonstrated the influence of aging in lung remodeling PMID: 29325453
  7. Melatonin inhibits epithelialtomesenchymal transition in gastric cancer cells via attenuation of IL1beta/NFkappaB/MMP2/MMP9 signaling PMID: 30066836
  8. TF-FVIIa/trypsin-mediated PAR2 activation leads to enhanced MMP-2 expression in human breast cancer cells contributing to tumor progression. PMID: 29870887
  9. proteins such as MMP2 and MMP9 as well as P38 expression were also affected by the PKM2 expression changes. These results proved that PKM2 could be involved in the progression of bladder cancer by mitogen-activated protein kinases signaling pathway. PMID: 30249877
  10. High MMP2 expression is associated with colorectal cancer cell migration, invasion and metastasis PMID: 30015978
  11. We conducted a case-control genetic association study, adjusted for known IA risk factors (smoking and hypertension), in a UK Caucasian population of 1409 patients with intracranial aneurysms (IA), and 1290 matched controls, to determine the association of the rs243865 C > T functional MMP-2 gene SNP with IA (overall, and classified as ruptured and unruptured). PMID: 29334797
  12. MMP2 rs243865 and MMP9 rs3918242 polymorphisms are significantly associated with the risk of RSA in Chinese population. PMID: 30290617
  13. findings demonstrate an association between the MMP-2 C-735 T polymorphism with blood pressure and the risk of preeclampsia PMID: 29017408
  14. The role of MMP 2 in asthma remains unclear and no study has been conducted till date, to determine the role of MMP-2 -735C/T gene polymorphism in asthma. This study does not disprove such association. PMID: 28051223
  15. knockdown of TRIM31 reduced the expression of MMP2, MMP9 and phospho-Akt. PMID: 29864908
  16. SB22055 could reduce the expression of BSP, OPN and MMP2 in prostate cancer cells. PMID: 29917166
  17. Therefore, the A allele of MMP2 rs2287074 could be a protective factor for brick tea skeletal fluorosis. PMID: 28079131
  18. MMP-2 genetic variants are an important mediator of stroke risk PMID: 30278505
  19. HMGB1 promoted lung cancer invasion and metastasis by upregulating the expression and activity of MMP-2 in an NF-kappaB-dependent manner. PMID: 29850505
  20. High glucose levels induce MMP-2 expression in Human cardiac fibroblasts , possibly by up-regulation of SGLT1. PMID: 29512713
  21. we have discovered the novel N-72, and it was crucial for EGF-induced migration by targeting MMP2 in Human amnion mesenchymal stem cells (hAMSCs) PMID: 29734654
  22. data indicated that MMP-2/MMP-9 was coordinately targeted by two non-coding RNAs, miR-296-3p and FOXCUT, which were decreased, and tumor-suppressing factors in choroidal malignant melanoma PMID: 29260433
  23. Increased MMP-2 and MMP-9 activities may contribute to the pathogenesis and disease severity of cutaneous lupus erythematosus. PMID: 29349515
  24. No association between the carriage of studied MMP2 polymorphisms and the predisposition to preeclampsia was found. PMID: 29670668
  25. We propose that serum levels of MMP-2 and MMP-9 are not predictive on treatment response and survival in LARC patients. PMID: 29578156
  26. that miR-338-5p has a function in promoting glioma cell invasion by targeting TSHZ3 suppression on MMP2 PMID: 28780604
  27. In dilation cardiomyopathy, expression of MMP-2, MMP-9, and TIMP-1 and their ratios in autopsy material and in cultures was elevated by 1.5-9 times. PMID: 29504111
  28. OSM [oncostatin M]might be involved in the invasiveness of extravillous trophoblasts under hypoxia conditions via increasing MMP-2 and MMP-9 enzymatic activities through STAT3 signaling. Increased MMP-9 activity by OSM seems to be more important in primary trophoblasts. PMID: 30091322
  29. TIMP2 promotes tumor progression and miR2055p directly regulates TIMP2, thereby suppressing proMMP2 activation and inhibiting oral squamous cell carcinoma cell invasiveness. PMID: 29393341
  30. Elevated MMP-2 levels were observed in blood of pancreatic cancer patients which correlated with its tissue expression. However, these levels did not associate with survival or any clinicopathological parameters of patients. PMID: 29355139
  31. Increased urinary concentration of matrix metallopeptidase 2 (MMP-2) at 12 and 16 weeks of gestation predicted an increased risk of developing preeclampsia in the study population. PMID: 28055277
  32. There was no difference found in MMP-2, MMP-9 or TLR-4 levels between non-thrombocytopenic and thrombocytopenic septic donors. PLA formation was increased in thrombocytopenic patients. PMID: 29734352
  33. MMP2 rs243865 was the only single nucleotide polymorphism significantly associated with Floppy Mitral Valve/Mitral Valve Prolapse (FMV/MVP) as compared to the control.The frequency of certain MMP2 polymorphisms is higher in patients with the FMV/MVP syndrome and patients with FMV/MVP without the syndrome. PMID: 28750369
  34. Platelets may contribute to joint degeneration in knee osteoarthritis by favouring the accumulation of MMP-2 in synovial fluid. PMID: 28981555
  35. In pregnancy MMP2 gene expression was significantly higher in preterm than full term. Human papilloma viral load was found to be positively correlated to the rate of MMP2 expression and the gestational age was significantly related to the viral load and the rate of expression of MMP2 gene. Human pabilloma virus especially high-risk genotypes was correlated to spontaneous preterm labor in Egyptian females. PMID: 28264621
  36. We conclude that S1P attenuates the invasion of C643 cells by activating S1P2 and the Rho-ROCK pathway, by decreasing calpain activity, and by decreasing the expression, secretion and activity of MMP2 and, to a lesser extent, MMP9. Our results thus unveil a novel function for the S1P2 receptor in attenuating thyroid cancer cell invasion. PMID: 29734379
  37. High mmp2 expression is associated with ovarian cancer cell migration and invasion. PMID: 28677781
  38. MMP-2 was expressed in high percentage of endometrial cancer and its expression may be associated closely with clinical stage, and tumor invasion and metastasis, indicating that MMP-2 overexpression may serve as a predictive factor for poor prognosis of endometrial cancer. PMID: 30024495
  39. MMP2 single nucleotide polymorphisms association with lymphedema caused by Wuchereria bancrofti. PMID: 29122006
  40. MMP-2 promoted and MMP-13 disrupted vasculogenic mimicry formation in large cell lung cancer by cleaving laminin-5 to influence EGFR signal activation. PMID: 28766880
  41. Data suggest that environmental carcinogen PFOA (perfluorooctanoic acid) stimulates ovarian cancer cell migration, invasion, and MMP2/MMP9 expression by up-regulating ERK/NFkappaB signaling pathway. (MMP = matrix metallopeptidase; NFkappaB = nuclear factor kappa B) PMID: 29753068
  42. Matrix-metalloproteinase-2 is implicated in the pathophysiological mechanism of stenosis development and has a predictive value for arteriovenous fistula failure in hemodialysis patients PMID: 28868755
  43. Fli1 functioned as an oncogene in HCC carcinogenesis and it exerted its promoting metastatic effect primarily by modulating the matrix metalloproteinase (MMP)2 signaling pathway. PMID: 29138848
  44. Rictor regulates the vasculogenic mimicry of melanoma and determines the patients' survival via the AKT-MMP2-MMP9 pathway. PMID: 28699701
  45. Expression of BRM and MMP2 in the thoracic aortic aneurysm and aortic dissection is very high, indicating that BRM and MMP2 may play important roles in the occurrence and development of thoracic aortic aneurysm and aortic dissection. PMID: 28678310
  46. at high endothelial shear stress, PI16 contributes to inhibition of MMP2 protease activity, protection that can be reversed during inflammation PMID: 27996045
  47. MMP-2 serum level and circulating tumor cells show the potential to predict CNS metastases and overall survival in breast cancer patients; CTCs and MMP-9 serum level could be a promising therapy response marker in castration resistant prostate cancer patients PMID: 28529342
  48. RhoGDIbeta overexpression led to downregulation of miR-200c, whereas miR-200c was able directly to target 3'-UTR of jnk2mRNA and attenuated JNK2 protein translation, which resulted in attenuation of Sp1mRNA and protein expression in turn, inhibiting Sp1-dependent MMP-2 transcription. PMID: 28846829
  49. both HBEGF upregulation and apoptosis were rescued by exogenous MMP2 PMID: 28731464
  50. MMP-2 (and MMP-1 and MMP-3) are independently associated with markers of arterial stiffening in patients with type 1 diabetes. PMID: 29070037
  51. The results suggest that SH3GL2 suppresses migration and invasion behaviors of glioma cells through negatively regulating STAT3/MMP2 signaling. PMID: 28470949
  52. MMP-2 (-1306 C/T) polymorphism is associated with exudative age-related macular degeneration development in younger males. PMID: 29582818
  53. these results suggest that Ascochlorin inhibits cell migration and invasion by blocking FAK and JAK/STAT signaling, resulting in reduced MMP-2 activity. PMID: 28569433
  54. We found that overexpression of AEG-1 in PTC was positively correlated with lymph node metastasis and MMP2/9 expression. Knockdown of AEG-1 reduced the capacity of migration and invasion through downregulation of MMP2/9 in thyroid cancer cells. Furthermore, we firstly found that AEG-1 interacted with MMP9 in thyroid cancer cells. PMID: 28731152
  55. MMP2/TIMP4 ratio is a marker of disease severity and right ventricular function as well as a predictor for survival and time to clinical worsening in idiopathic pulmonary arterial hypertension. PMID: 28516393
  56. The study indicates MMP2-1306 C/T polymorphism might increase prostate cancer risk, particularly for Asian population. PMID: 28445160
  57. Findings indicate that IL33 may be involved in the process of glioma cell invasion and migration by upregulating MMP2 and MMP9 via the ST2-NF-kappaB signaling pathway. PMID: 28849217
  58. One important finding of the present study was that MMP-3 appears to be involved solely in early-onset preeclampsia, but not in late-onset preeclampsia. Higher levels of MMP-2 and MMP-13 and lower levels of MMP-9 seem to be related to both early- and late-onset severe preeclampsia. PMID: 28798935
  59. our study reveals that TRIB1 promotes CRC cell migration and invasion by up-regulating the expression of MMP-2 via the activation of FAK/Src and ERK pathways, knockdown of TRIB1 expression in CRC cells abolishes these effects. PMID: 28624785
  60. Secretagogin-dependent MMP2 release from neurons regulates neuroblast migration. PMID: 28223495
  61. Wnt5a-Ror2 signaling enhanced tongue SCC cell aggressiveness and promoted production of MMP-2 following DeltaNp63beta-mediated EMT PMID: 28559016
  62. The expression of MMP-2 and MMP-9 is associated with angiogenesis in pancreatic cancer PMID: 26866436
  63. High expression of MMP2 is associated with invasion of gastric cancer. PMID: 28534988
  64. different behavior between whole MMP-2 and cdMMP-2 envisages the occurrence of an additional binding site for the peptide on the hemopexin-like domain of MMP-2 PMID: 29447293
  65. miR-516a-5p may regulate MTHFR, MMP-2, and TIMP-1 expressions in vascular smooth muscle cells, possibly promoting the disruption of homocysteine metabolism and proteolytic degradation of elastin for abdominal aortic aneurysm formation. PMID: 28288890
  66. In this study, serum matrix metalloproteinase-2 level is increased in the active acromegaly patients and a threshold value in determining active disease was defined for serum matrix metalloproteinase-2 level. PMID: 28332074
  67. Collectively, our data indicates MMP-2 and MMP-9 drive metastatic pathways, including migration, viability and secretion of angiogenic factors in Retinoblastoma cells. These two subtypes of matrix metalloproteinases represent new potential candidates for targeted anti-metastatic therapy for Retinoblastoma. PMID: 28633655
  68. cytomembrane MMP14 was induced by IL-6 secreted from astrocytes, thereby enhancing the migration and invasion of glioma cells through activation of MMP2 PMID: 27613828
  69. combined administration of small-interfering RNA (siRNA) transfection with PPARgamma ligands induced downregulation of SOX2 and MMP2 activity together with inhibition of sphere-forming activity regardless of poly(ADP-ribose) polymerase (PARP) cleavage. Taken together, our findings suggest that a combination therapy using PPARgamma ligands and its inhibitor could be a potential therapeutic strategy targeting glioblastom... PMID: 28642874
  70. Selenium suppressed high-fat diet-induced MMP2 over-expression in vivo by improving lipid metabolism. PMID: 28595793
  71. GA + AA genotypes of rs243866 SNP may associate with a decreased risk of age-related macular degeneration (AMD) in in the agePMID: 29381911
  72. miR-93 inhibits MMP-2 and reduces migration and invasion of immortalized trophoblast cells. PMID: 28487020
  73. The migration of dermal endothelial cells undergoing epithelial-mesenchymal transition is dependent on both extracellular matrix degradation and invadosome formation associated with MMP-2 proteolytic activity and Rho/ROCK cytoskeleton contraction. PMID: 28487031
  74. MMP-2 mRNA levels were significantly decreased in scleral fibroblasts and RPE cells transfected with the miR-29a mimics. The secretion of MMP-2 by scleral fibroblasts and RPE cells was significantly decreased in cells transfected with the miR-29a mimics. PMID: 28630860
  75. C-type natriuretic peptide (CNP)administration significantly decreased the secretion and expression of MMP-2 and MMP-9 in the cultured mesangial cells ; (2) the secretion and expression of TIMP-1 progressively elevated after treatment with CNP for 24 and 48 h, whereas declined at later time point; (3) CNP expression was negatively correlated with MMP-2 and MMP-9 expression. PMID: 28554303
  76. No significant association was found between MMP2 and MMP9 genetic variation and spontaneous abortion in an Indian population. PMID: 28500450
  77. Our findings show that emmprin is released through microvesicle shedding in sarcoma cells, and emmprin in microvesicles regulates MMP-2 production by influencing the activity of fibroblasts located at sites distant from the tumor cells. PMID: 28498412
  78. Our results showed that select cytokines, mitogens and inhibitors modulated A-2058 MMP-2 and MMP-9 expression. They suggest the clinical potential of MMP inhibitors, especially the non-toxic ones, such as the nutrient mixture and its component EGCG in management of melanoma PMID: 28440509
  79. Cullin1 and MMP-2 expressions could be novel diagnostic and prognostic markers for colorectal cancer patients. PMID: 28269751
  80. eIF4E promoted cholangiocarcinoma cell metastasis by up-regulating the expression of VEGF-C, MMP-2 and suppressing E-cadherin expression. PMID: 27907907
  81. Knockdown of CREB suppressed the expression of matrix metallopeptidase (MMP)2/9. PMID: 28487942
  82. the frequencies of genotypes and alleles of candidate genes with respect to polymorphisms associated with increased pregnancy loss in the first trimester of pregnancy, including MMP1-1607insG, MMP9 A-8202G, and TIMP1 capital ES, Cyrillic536T, were reported PMID: 29369548
  83. MMP2 expression was potently associated with high-WHO grade gliomas in a Chinese population. PMID: 26729052
  84. These findings may add to the understanding of epigenetic modification of MMP-2 on ischemic stroke. PMID: 28193703
  85. Study provides evidence supporting that rs243866/rs243865 in the MMP-2 gene might be involved with blood pressure levels in obese resistant hypertensive subjects. PMID: 29288728
  86. Data suggest that the MMP-2 -735 CT genotype, -735 T allele and combined genotype of MMP-2-735TT + MMP-9-1562CC were to have protection from developing severe HIV-associated neurocognitive disorders (HAND). PMID: 27551834
  87. study results suggest an association between matrix metalloproteinase 2, matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 2 single nucleotide polymorphisms with sperm parameters, but not infertility PMID: 27401679
  88. After a course of electroconvulsive therapy, MMP-2 levels were significantly increased in mood disorder patients, but MMP-9 levels were significantly decreased in both mood disorder and schizophrenia patients. In mood disorder patients, there was a significant negative correlation between depressive symptoms and serum levels of MMP-2 and a positive correlation between depressive symptoms and MMP-9. PMID: 26912606
  89. MMP2-1306C/T and TIMP2-418 G/C gene variants as risk factors for patients with relapsing remitting multiple sclerosis, was studied. PMID: 27174941
  90. The expression of RECK in human healthy and diseased gingiva may contribute to periodontal physiological and pathological processes; low RECK expression may be associated with the enhanced MMP-2 and MMP-9 production in inflamed gingiva. PMID: 28043014
  91. Results continue to establish ANG as an oncoprotein and further reveal that ANG contributes to oncogenesis by the activation of MMP2 through modulation of DNMT3b functions. PMID: 27317771
  92. This study demonstrated that MMP2 higher expression in glioblastoma PMID: 27633774
  93. GABRA3 induced MMP-2 and MMP-9 expression through activation of the JNK/AP-1 signaling pathway, promoting lymphatic metastasis in lung adenocarcinoma. PMID: 27081042
  94. Kinase activation led to increased MMP-2 and MT1-MMP expression and melanoma cell migration induced by hHK-1. Thus, hHK-1 and the NK1 receptor are critical to melanoma cell migration and each may be a promising chemotherapeutic target PMID: 27458061
  95. MMP2/9 are elevated in epicardial adipose tissue from patients with coronary artery disease. PMID: 27781958
  96. TSP-2 enhances the migration of PCa cells by increasing MMP-2 expression through down-regulation of miR-376c expression. PMID: 28122633
  97. Concentrations of MMP-2 and MMP-9 in serum in humans measured after acute stroke are potentially influenced by extraneous covariates rather than being directly associated with characteristics of the underlying stroke. PMID: 27322408
  98. There were no differences in activities of MMP-2, proMMP-9, and MMP-9/NGAL (neutrophil gelatinase associated lipocalin) complex (gelatin substrate) in men with detected prostate cancer, although the latter two were somewhat diminished. PMID: 29175302
  99. Data indicate that the matrix metallopeptidases MMP-2/MMP-9 ratio provided better compromise between specificity and sensitivity in distinguishing PE from normal pregnancies, than either of the two MMPs alone. PMID: 28143958
  100. The A/A genotype (OR=0.120) and A allele (OR=0.442) reduce the risk of recurrent depressive disorder occurrence in the examined polymorphisms for MMP-2, MMP-7 and MMP-9. PMID: 27434116

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Involvement in disease Multicentric osteolysis, nodulosis, and arthropathy (MONA)
Subcellular Location Isoform 1: Secreted, extracellular space, extracellular matrix, Membrane, Nucleus
Protein Families Peptidase M10A family
Tissue Specificity Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate.
Database Links

HGNC: 7166

OMIM: 120360

KEGG: hsa:4313

STRING: 9606.ENSP00000219070

UniGene: Hs.513617

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