Phospho-CD19 (Tyr531) Antibody

Datasheet
Code CSB-PA058389
Product Type Polyclonal Antibody
Size US$360
Uniprot No. P15391
Image
  • Western blot analysis of extracts from COS7 cells treated with Serum using Phospho-CD19 (Tyr531) antibody.The lane on the right is treated with the antigen-specific peptide.
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunogen Peptide sequence around phosphorylation site of tyrosine 531 (D-S-Y(p)-E-N) derived from Human CD19.
Raised in Rabbit
Species Reactivity Human,Mouse
Specificity The antibody detects endogenous level of CD19 only when phosphorylated at tyrosine 531.
Tested Applications ELISA,WB;WB:1:500-1:1000
Relevance

Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.

Ishiura N, et al. (2010)Eur J Immunol 40, 1192-204. Browne CD, et al. (2009) Immunity 31, 749-60. Aiba Y, et al. (2008)Blood 111, 1497-503.

Form Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
Clonality Polyclonal
Alias B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; CD19; CD19 molecule; MGC12802
Immunogen Species Homo sapiens (Human)
Target Names CD19
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
Involvement in disease Immunodeficiency, common variable, 3 (CVID3)
Subcellular Location Membrane, Single-pass type I membrane protein
Database Links

HGNC: 1633

OMIM: 107265

KEGG: hsa:930

STRING: 9606.ENSP00000437940

UniGene: Hs.652262

Pathway PI3K-Akt signaling pathway
B cell receptor signaling pathway
Hematopoietic cell lineage

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