Code | CSB-EP001481HU3 |
Size | $306 |
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The recombinant Human AHR was expressed with the amino acid range of 220-420. The calculated molecular weight for this AHR protein is 29.0 kDa. This AHR recombinant protein is manufactured in e.coli. The AHR coding gene included the N-terminal 10xHis tag, which simplifies the detection and purification processes of the recombinant AHR protein in following stages of expression and purification.
The human Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor involved in various physiological processes, including xenobiotic metabolism, immune response, and development. AHR is primarily known for its role in sensing environmental pollutants, such as dioxins and polycyclic aromatic hydrocarbons. Upon ligand binding, AHR translocates to the nucleus, forms a complex with its coactivators, and modulates the expression of target genes, including those encoding xenobiotic-metabolizing enzymes. Beyond its detoxification functions, AHR has been implicated in immune regulation, influencing the differentiation of immune cells. AHR's diverse roles make it a significant player in environmental toxicology, immunology, and developmental biology, with potential implications for human health and disease.Applications : Surface Plasmon Resonance (SPR) experiments
Review: Nuclear and cytosolic fraction separation of AHR and NRF2 protein performed 1–6 h after BaP exposure (1 μM); SPR characterization of binding kinetics between BaP and AHR protein that was immobilized on CM5 sensor chip; AHR protein degradation after 24 h of BaP exposure implying AHR activity in a dose-dependent manner. Three independent exper_x005fiments were carried out, and data was shown as mean ± SD. *P < 0.05 as indicated.
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