Recombinant Hypoxia-inducible factor 1 (hif-1), partial

1. Our results suggest that these detoxification pathways are mediated by the hypoxia inducible factor HIF-1. Finally, we show that sulfide resistance varies among wild C. elegans and other nematode species, suggesting that tolerance to sulfide was naturally selected in certain habitats. PMID: 28179109
2. blocking HIF-1 activity may promote survival in cells with compromised mitochondrial function. PMID: 27618966
3. HIF-1-mediated activation of 5-HT signalling promotes axon regeneration by activating both the RhoA and cAMP pathways. PMID: 26790951
4. AMPK and HIF-1 may control immunity and longevity tightly by acting as feedback regulators of ROS PMID: 25288734
5. HIF can function either as a gene-specific inducer or repressor of host defense, providing a molecular mechanism by which HIF can have apparently opposing roles in defense and inflammation. PMID: 22792069
6. Increased levels of hydrogen peroxide induce a HIF-1-dependent modification of lipid metabolism in AMPK compromised C. elegans dauer larvae. PMID: 22921415
7. These data show that HIF-1 regulates intestinal iron homeostasis during iron deficiency by activating and inhibiting genes involved in iron uptake and storage. PMID: 22194696
8. Data show that stabilization of HIF-1 increases life span robustly under all conditions tested; however, deletion of hif-1 increases life span in a temperature-dependent manner. PMID: 21241450
9. Data show that that reactive oxygen species (ROS) are increased in respiration mutants and that mild increases in ROS can stimulate HIF-1 to activate gene expression and promote longevity. PMID: 21093262
10. transgerminal neuroectodermal conversion of hMSCs into NSC-like cells is accompanied by extensive changes of their global gene expression profile, which might be controlled in part by transcription factor networks related to HIF-1 and miR-124a PMID: 20599952
11. HIF-1 upregulation is both an evolutionarily conserved and a necessary component of heat acclimation. PMID: 12686697
12. In Caenorhabditis elegans the product of the hif-1 gene plays a crucial role in heat adaptation. PMID: 12824472
13. studies identified hypoxia-regulated gene expression changes requiring hypoxia-inducible transcription factor (HIF-1) function in response to low oxygen levels PMID: 15781453
14. Hypoxia caused specific axon pathfinding and neuronal migration defects in C. elegans that result from the stabilization of the transcription factor HIF-1 (hypoxia-inducible factor 1) in neurons and muscle. PMID: 18587389
15. loss of VHL-1 increased life span; deletion of HIF-1 was epistatic to VHL-1, indicating HIF-1 acts downstream of VHL-1 to modulate aging; VHL-1 & HIF-1 control longevity by a mechanism distinct from dietary restriction & insulin-like signaling PMID: 19372390
16. HIF-1 deficiency results in extended lifespan, which overlaps with that by inhibition of the RSKS-1/S6 kinase, a key component of the TOR pathway. PMID: 19461873
17. C. elegans are protected from lethal hypoxia by an embryonic diapause, and neuronal HIF-1 activity in the adult dictates the O(2) tension at which the diapause is engaged. PMID: 19576771
18. data establish HIF-1 as one of the key stress-responsive transcription factors that modulate longevity in C. elegans and advance our understanding of the regulatory networks that link oxygen homeostasis and aging PMID: 19633713

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KEGG: cel:CELE_F38A6.3

STRING: 6239.F38A6.3b

UniGene: Cel.17085