Recombinant Mouse Angiotensin-converting enzyme 2(Ace2),partial

Code CSB-YP851244MO
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Source Yeast
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Code CSB-EP851244MO
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Source E.coli
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Code CSB-EP851244MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP851244MO
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Source Baculovirus
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Code CSB-MP851244MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Ace2
Uniprot No. Q8R0I0
Alternative Names Ace2; Angiotensin-converting enzyme 2; EC 3.4.17.23; ACE-related carboxypeptidase) [Cleaved into: Processed angiotensin-converting enzyme 2]
Species Mus musculus (Mouse)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. May have a protective role in acute lung injury.
Gene References into Functions
  1. ACE2/A1-7/Mas axis may be one of the intra-islet paracrine mechanisms of communication between alpha and beta cells. Enhancing the ACE2/A1-7 axis exerts a protective effect by ameliorating beta cell dedifferentiation. PMID: 29225087
  2. ACE2 is a novel factor required for exercise-dependent modulation of adult neurogenesis and essential for serotonin metabolism. PMID: 29679094
  3. High ACE2 expression is associated with acute lung injury. PMID: 29990483
  4. These results were supported by the opposite outcomes observed for cells treated with A779 or DX600. Therefore, it was concluded that the ACE2-Ang(17)-Mas axis significantly inhibits pancreatitis by inhibition of the p38 MAPK/NF-kappaB signaling pathway PMID: 29138810
  5. Exogenous ACE2 alters angiotensin peptide metabolism in the kidneys of Col4a3 knockout mice and attenuates the progression of Alport syndrome nephropathy. PMID: 28249676
  6. Profound augmentation of ACE2 confined to the circulation failed to ameliorate the glomerular lesions and hyperfiltration characteristic of early diabetic nephropathy. PMID: 27927599
  7. Nrf2-mediated stimulation of intrarenal Renin-Angiotensin syste, (CAE2 and MasR) gene expression, by which chronic hyperglycemia induces hypertension and renal injury in diabetes. PMID: 29211853
  8. In islets from db/db mice, ACE2 over-expression increased intracellular calcium influx and restored impaired mitochondrial oxidation, potentially causing an increase in GSIS. These results shed light on the potential roles of ACE2 in mitochondrial metabolism, moreover, may improve our understanding of diabetes. PMID: 29128354
  9. Ultra-high doses did not influence the ACE2/AT2R/Mas axis and promoted renal injury with increased renal ERK1/2 activation and exaggerated fibronectin expression in db/db mice. Our study demonstrates dose-related effects of candesartan in diabetic nephropathy: intermediate-high dose candesartan is renoprotective, whereas ultra-high dose candesartan induces renal damage. PMID: 27612496
  10. Altogether, our study demonstrates that HFD feeding increases RAS activity and mediates glycemic dysregulation likely through loss of ACE2 present outside the islets but independently of changes in islet ACE2. PMID: 27806985
  11. Results suggest that angiotensin converting enzyme 2 may reduce anxiety-like behavior by activating central Mas receptor that facilitate GABA release onto pyramidal neurons within the basolateral amygdala. PMID: 26767952
  12. These findings demonstrate that ACE2 plays a critical role in preventing RSV-induced lung injury, and suggest that ACE2 is a promising potential therapeutic target in the management of RSV-induced lung disease. PMID: 26813885
  13. ACE2 overexpression significantly reduced the myocardial infarction-induced increase in apoptosis, macrophage infiltration, and HMGB1 and proinflammatory cytokine expression. PMID: 26498282
  14. ACE2 regulates vascular function by modulating nitric oxide release. PMID: 27070147
  15. MAS receptors mediate vasoprotective and atheroprotective effects of candesartan upon the recovery of vascular ACE2-angiotensin-(1-7)-MAS axis functionality PMID: 26144375
  16. ACE2 plays a novel role in heart disease associated with obesity wherein ACE2 negatively regulates obesity-induced epicardial adipose tissue inflammation and cardiac insulin resistance. PMID: 26224885
  17. a Mas receptor-mediated mechanism may stimulate pancreatic cell development PMID: 26029927
  18. ACE2 deficiency exacerbates kidney inflammation, oxidative stress and adverse renal injury in the ApoE-mutant mice through modulation of the nephrin, NOX4 and TNF-alpha-TNFRSF1A signaling. PMID: 26245758
  19. Hydronephrosis led to an increase of ACE level and a decrease of ACE2 and Mas receptor in the heart. PMID: 25650385
  20. Overexpression of ADAM17 increases shed ACE2 and decreases cellular ACE2 levels in pancreatic islets. Whereas ADAM17 has the ability to shed ACE2, ADAM17 does not deplete ACE2 from pancreatic islets in diabetic db/db mice. PMID: 26441236
  21. ACE2 and Ang-(1-7) significantly inhibit early atherosclerotic lesion formation via protection of endothelial function and inhibition of inflammatory response. PMID: 25721616
  22. These results demonstrate a critical role for endogenous ACE2 in the adaptive beta-cell hyperinsulinemic response to High Fat feeding through regulation of beta-cell proliferation and growth. PMID: 26389599
  23. ACE2 deficiency worsened the influenza pathogenesis markedly, mainly by targeting the angiotensin II type 1 receptor (AT1). PMID: 25391767
  24. Placental hypoxia and uterine artery dysfunction develop before major growth of the fetus occurs and may explain the fetal growth restricted phenotype in Ace2 knock-out pregnant mice. PMID: 25968580
  25. Beneficial effects of E2 to decrease blood pressure in ovariectomized obese females may result from stimulation of adipose ACE2. PMID: 26078188
  26. In experimental mouse models, infection with highly pathogenic avian influenza A H5N1 virus results in downregulation of angiotensin-converting enzyme 2 (ACE2) expression in the lung and increased serum angiotensin II levels. PMID: 24800825
  27. Whole-body deficiency of ACE2 significantly increased aortic lumen diameters and external diameters of suprarenal aortas from AngII-infused mice. PMID: 25301841
  28. Brain-targeted angiotensin-converting enzyme 2 overexpression attenuates neurogenic hypertension by inhibiting cyclooxygenase-mediated inflammation. PMID: 25489058
  29. Partial loss of ACE2 is sufficient to enhance the susceptibility to heart disease. PMID: 24728465
  30. Suggest that the ACE2-ACE imbalance plays an important role in the pathogenesis of severe acute pancreatitis and that pancreatic ACE2 is an important factor in determining the severity of SAP. PMID: 24414175
  31. Expression of ACE2 reduced the fibrosis. PMID: 24695436
  32. Angiotensin converting enzyme 2/Ang-(1-7)/Mas axis protects brain from ischemic injury via the Nox/ROS signaling pathway, with a greater effect in older mice PMID: 24581232
  33. ACE2 deficiency promotes the development of vascular diseases associated with Ang-II-mediated vascular inflammation and activation of the JNK signalling, leading to the notion that ACE2 potentially confers protection against vascular diseases. PMID: 24193738
  34. Proximal tubular shedding of ACE2 may increase in diabetes. PMID: 24454948
  35. This study also shows that serum and urine ACE2 activity is increased in the NOD mouse model of diabetes starting at an early stage of the disease. PMID: 24400109
  36. Loss of ACE2 exacerbates AngII-mediated inflammation, myocardial injury and dysfunction in ACE2-deficient hearts via activation of the CTGF-FKN-ERK and MMP signaling. PMID: 24161906
  37. Suggest that ACE2 plays a key role in the recruitment of the renal reserve and hyperfiltration associated with diabetes. PMID: 24477684
  38. blockade of the AT1 receptor by azilsartan could enhance the activities of the ACE2/Ang-(1-7)/Mas axis and ACE2/Ang-(1-7)/AT2 receptor axis, thereby inhibiting neointimal formation. PMID: 24379178
  39. These results suggest that ACE2 plays an important role in postnatal development of the heart, and that lack of ACE2 enhances coronary artery remodeling with an increase in perivascular fibrosis and cardiac hypertrophy already around the weaning period. PMID: 23608725
  40. ACE2 has a protective role in murine renal ischemia-reperfusion injury. PMID: 23951161
  41. ACE2 was downregulated in apelin-deficient mice. Apelin, via activation of its receptor, APJ, increased ACE2 promoter activity in vitro and upregulated ACE2 expression in failing hearts in vivo. ACE2 couples the RAS to the apelin system. PMID: 24177423
  42. Unlike angiotensin-converting enzyme 2, collectrin lacks any catalytic domain. PMID: 24048198
  43. Urinary ACE2 could be a potential biomarker of increased metabolism of ANG II in diabetic kidney disease. PMID: 23761674
  44. A cardioprotective and vascular protective role is documented for ACE2 under pathological conditions. PMID: 23043153
  45. This review summarizes and discusses the structure and multiple functions of ACE2 and the relevance of this key enzyme in disease pathogenesis. PMID: 23328447
  46. ACE2 metabolizes ANG II in the kidney at neutral and basic pH, while prolylcarboxypeptidase catalyzes the same reaction at acidic pH. PMID: 23392115
  47. Upregulation of the angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas receptor axis in the heart and the kidney of growth hormone receptor knock-out mice PMID: 22947377
  48. Severe acute pancreatitis is associated with upregulation of the ACE2-angiotensin-(1-7)-Mas axis and promotes increased circulating angiotensin-(1-7). PMID: 23127535
  49. ACE2 protects against high-calorie diet-induced insulin resistance in mice. This mechanism may involve the transcriptional regulation of GLUT4 via an A1-7-dependent pathway. PMID: 22933108
  50. ACE2 deficiency impaired endothelial function in cerebral arteries from adult mice and augmented endothelial dysfunction during aging. PMID: 23160880

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Subcellular Location Processed angiotensin-converting enzyme 2: Secreted, SUBCELLULAR LOCATION: Cell membrane, Single-pass type I membrane protein, Cytoplasm
Tissue Specificity Expressed in heart, kidney and forebrain (at protein level). Ubiquitously expressed, with highest levels in ileum, kidney and lung. In lung, expressed on vascular endothelial and airway epithelial cells.
Database Links

KEGG: mmu:70008

STRING: 10090.ENSMUSP00000073626

UniGene: Mm.13451

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