Recombinant Mouse Signal transducer CD24(Cd24)

Code CSB-YP329506MO
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Source Yeast
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Code CSB-EP329506MO
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Source E.coli
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Code CSB-EP329506MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP329506MO
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Source Baculovirus
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Code CSB-MP329506MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Cd24
Uniprot No. P24807
Alternative Names Cd24; Cd24a; Ly-52; Signal transducer CD24; Lymphocyte antigen 52; Ly-52; M1/69-J11D heat stable antigen; HSA; Nectadrin; R13-Ag; X62 heat stable antigen; CD antigen CD24
Species Mus musculus (Mouse)
Expression Region 27-53
Target Protein Sequence NQTS VAPFPGNQNI SASPNPSNAT TRG
Protein Length Cytoplasmic domain
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
May have a pivotal role in cell differentiation of different cell types. May have a specific role in early thymocyte development. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity.
Gene References into Functions
  1. CD24 and CD49f expressions of E14.5 mouse mammary anlagen cells define putative distribution of earlier embryonic mammary stem cell activities. PMID: 29620414
  2. CD24 has a role in determining the epithelial phenotype of pancreatic cancer PMID: 27203385
  3. While no obvious role was found for CD24 in the normal development and maintenance of the dopaminergic nigrostriatal system in mice, it may have a role in mediating the neuroprotective aspects of GDNF in this system. PMID: 28182766
  4. CD24 cell surface expression may serve as a valuable biomarker in order to identify mammary tumors that will positively respond to targeted IGF1R therapies. PMID: 27179633
  5. mice negative or positive for CD24 did not differ in terms of tumor initiation and burden in 3 mammary and prostate tumor models tested, except for Apc1572T/+ mice, in which lack of CD24 reduced the mammary tumor burden slightly but significantly. PMID: 26978528
  6. Loss of CD24 in Mice Leads to Metabolic Dysfunctions and a Reduction in White Adipocyte Tissue. PMID: 26536476
  7. CD24 controls breast cancer radiation response. Loss of CD24 expression leads to radiation resistance. PMID: 25641732
  8. Delayed wound-healing in the absence of HSA/CD24 suggests that CD24 plays an important role in this process PMID: 26440795
  9. Findings indicate that CD24(+) antigen cells play a role in tumor migration and metastasis and support Janus kinase 2 protein (JAK2) as a therapeutic target in ovarian cancer. PMID: 25969154
  10. CD24 is a conserved marker for tracking divergent states in both reprogramming and standard pluripotent culture. PMID: 26076835
  11. CD24 in non-immune cells might be crucialfor the guidance and recruitment of leukocytes. PMID: 24956310
  12. CD24 expression negatively regulates the NF-kappaB pathway following experimental traumatic brain injury. PMID: 23881416
  13. the deletion of CD24 in an HSP-driven model of autoimmunity led to the unexpected development of regulatory T cell and MDSC populations that augmented immune tolerance. PMID: 24808359
  14. CD24 is shown in vitro and in vivo as being an important oncogene in the gut, and one that plays a critical role in the initiation and progression of carcinogenesis. PMID: 24500912
  15. Siglec-G-CD24 axis, controls the severity of GVHD and suggest that enhancing this interaction may represent a novel strategy for mitigating GVHD. PMID: 24695850
  16. CD24 was shown to regulate CD8(+) T cell activation through HMGB1-mediated engagement of T cell RAGE. PMID: 24631155
  17. CD24 has a role in urothelial tumorigenesis and metastasis in male mice and is androgen regulated in mice and humans PMID: 23012401
  18. CD24 is expressed in gastric parietal cells, where it modulates gastric responses to H. felis and gamma-radiation. CD24 also regulates susceptibility to apoptosis in the distal murine gastrointestinal tract. PMID: 22899822
  19. CD24-based sorting in wild-type mice isolates a colonic epithelial fraction highly enriched in actively cycling and quiescent Lgr5 positive putative colonic epithelial stem cells. PMID: 22723265
  20. Results suggest that LKB1 inactivation in the context of RAS activation facilitates metastasis by inducing an SFK-dependent expansion of a prometastatic, CD24(+) tumor subpopulation. PMID: 22698401
  21. CD24 expression on thymic antigen-presenting cells (mTECs, DCs) down-regulates autoantigen-mediated clonal deletion of autoreactive thymocytes. PMID: 22213356
  22. The isolation and characterization of a rare, primary, nonhematopoietic, CD24+ progenitor cell population from normal, untreated mouse liver, is described. PMID: 21361791
  23. Report sorting mouse jejunal epithelial cells with CD24 yields a population with characteristics of intestinal stem cells. PMID: 21183658
  24. CD24 is expressed in an NFAT5-dependent manner during the mitogenic expansion of mature T lymphocytes under hypertonic conditions and is required to sustain T cell expansion under osmostress. PMID: 21037089
  25. antigen CD24 is not a major regulator of mammary stem/progenitor cell function, but rather plays a role in governing branching morphogenesis. PMID: 20352469
  26. CD24 is expressed in the Sox9(EGFPlo) population and marks intestinal epithelial stem cells that form organoids in culture. PMID: 20185687
  27. mice with a targeted mutation of CD24 are resistant to induction of experimental autoimmune encephalomyelitis PMID: 19786366
  28. Dynamic changes in surface expression of the identified antigens CD15, CD24, and CD29 in combination can be exploited for the experimental separation of key neural cell populations. PMID: 19725119
  29. N-glycans of the mouse glycoprotein HSA and its human analogue CD24 from lymphoblastoma, neuroblastoma and astrocytoma cell lines as well as from mouse brain homogenate were analysed and compared to each other PMID: 12829373
  30. CD24 has a role in risk and progression of multiple sclerosis PMID: 14657362
  31. Mouse CD24 acts cell nonautonomously to regulate transit-amplifying cells proliferation and/or differentiation in adult SVZ. PMID: 15737737
  32. These results demonstrate a novel role for CD24 as a regulator of CXCR4 function that could be relevant for breast cancer growth and metastasis. PMID: 16390867
  33. CD24 is required for normal presynaptic maturation and function. PMID: 16606832
  34. These results and previous published data indicate that mCD24 contributes to the regulation of the production of differentiated cells by controlling the proliferation/differentiation balance between transit-amplifying and committed differentiated cells. PMID: 17522896
  35. CD24 is not essential for exosome formation or release but may be a convenient exosome marker. Our studies suggest that exosomal secretion from the embryonic kidney could play a biological role at the fetal-maternal interphase. PMID: 17700640
  36. elongation, collateralization, fasciculation and path finding of corticospinal axons in mice proceed normally in the absence of CD24. PMID: 18022325
  37. CD24a expression levels discriminate Langerhans cells from dermal dendritic cells in murine skin and lymph nodes PMID: 18185529
  38. CD44 but not CD24 may be involved in the breast cancer pathway and is a target for oncolytic virotherapy PMID: 18632604
  39. results reveal that the CD24-Siglec G pathway protects the host against a lethal response to pathological cell death and discriminates danger- versus pathogen-associated molecular patterns PMID: 19264983
  40. interaction of CD24 with the cell adhesion molecule L1 is mediated by O-linked glycans carrying alpha2,3-linked sialic acid PMID: 19284289
  41. CD24 expressed on T cells is essential for homeostatic proliferation in lymphopenic host. PMID: 15477346

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Subcellular Location Cell membrane; Lipid-anchor, GPI-anchor.
Protein Families CD24 family
Tissue Specificity In lymphoid, myeloid, and erythroid cells.
Database Links

KEGG: mmu:12484

STRING: 10090.ENSMUSP00000057983

UniGene: Mm.29742

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