CD24 Research Reagents

CD24 is a heat-stable antigen that belongs to the group of glycosylphosphatidylinositol (GPI)-anchored cell surface proteins. CD24 was originally thought to be a marker for B cells and is expressed in the early stages of B cell differentiation, while playing an important role in lymphocyte maturation, neurological development, and tissue renewal in biological process. Moreover, CD24 expression also has been largely identified in cells of the hematopoietic system, neural tissue and some specific epithelial cells. Importantly, CD24 is aberrantly expressed in solid tumors, inflammatory tissues and certain cells of autoimmune disorder. Numerous studies implied that CD24 can have dual and opposing effects on health states and deficient health states. In the health states, CD24 inhibits tissue growth, but in the deficient health states, CD24 promotes cell proliferation.

The diverse physiological properties trigger the interest of CD24 in therapeutic studies of autoimmune diseases, inflammation, tumors, and other diseases. However, the mechanism is still unknown. In 2019, a study revealed a significant role for the CD24/Siglec-10 signaling pathway in ovarian and breast cancer tumors, suggesting that CD24 interacts with Siglec-10 (sialic-acid- binding Ig-like lectin10) on macrophages. The binding of CD24 and Siglec-10 could inhibit phagocytosis of tumor cells by macrophages. On the contrary, knockdown of CD24 or Siglec-10 could promote phagocytosis. Therefore, CD24 as the novel immunotherapy target, is a newly discovered "don't eat me" signaling protein, like the popular molecular CD47.

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Popular Product

Recombinant Human Signal transducer CD24(CD24)-Nanoparticle (Active) (CSB-MP004902HU)

Validated Data

Purity determined
by SDS-PAGE

Greater than 95% as determined by SDS-PAGE.

The binding activity of ligand-receptor validated by functional ELISA

Immobilized human CD24 at 2 μg/ml can bind anti-CD24 recombinant Monoclonal Antibody (CSB-RA004902A0HU), the the EC₅₀ is 5.409-8.219 ng/ml.