Recombinant Rat Interleukin-6(Il6)

Code CSB-YP322670RA
Size Pls inquire
Source Yeast
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP322670RA
Size Pls inquire
Source E.coli
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP322670RA-B
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-BP322670RA
Size Pls inquire
Source Baculovirus
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-MP322670RA
Size Pls inquire
Source Mammalian cell
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Purity >85% (SDS-PAGE)
Target Names Il6
Uniprot No. P20607
Alternative Names Il6; Il-6; Interleukin-6; IL-6
Species Rattus norvegicus (Rat)
Expression Region 25-211
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Earn $30 Amazon Card or 20μL/μg CUSABIO Trial Size Antibody. Details of rewards >>

Target Background

(From Uniprot)
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation (By similarity).
Gene References into Functions
  1. In summary, this study demonstrated that IL-6 enhances mitochondrial biogenesis and survival in astrocytes under experimental septic conditions. Additionally, IL-6 plays the pro-survival role through IL-6/AMPK signaling pathway. PMID: 29674256
  2. Aerobic exercise improves the lipid metabolism disorder and interferes with germ cell apoptosis by reducing interleukin-6 and interleukin-6 receptor expression in nutritional obesity rat model. PMID: 28776758
  3. These findings indicated that IL-6 might exert dual effects on tendon-derived stem cells in vitro: strongly enhancing their proliferation but inhibiting their tenogenic differentiation via the JAK/Stat3 pathway. PMID: 29547593
  4. in adjuvant arthritis fibroblast-like synoviocytes, MeCP2 mediates hypermethylation of PTCH1 gene and decreases the expression of PTCH1 protein, thus activating Hedgehog signaling pathway and increasing secretion of IL-6 and TNF-alpha. PMID: 28573530
  5. IL-6 expression increased in all groups compared to control. Lgr5 expression was up-regulated in cells exposed to a single stressor, but down-regulated when multiple stressors were administered. PMID: 29018960
  6. IL-6 synthesis and secretion were connected to acute peritoneal dialysis fluid exposure, and this response was triggered by TRPA1 receptors, possibly located to non-neuronal cells. PMID: 28698251
  7. The interleukin 6 (IL-6)-174 polymorphism was significantly associated with prostate cancer in Slovak patients. PMID: 29848725
  8. The present study demonstrated that IL-6 RNA interference may protect the lung from acute lung injury induced by intestinal ischemia/reperfusion, and that this protective role may be associated with upregulation of IL-10. PMID: 28713893
  9. In the present study, isolated rat peritoneal mesothelial cells were treated with TGF-beta1 and/or IL-6 which elicited mesenchymal transition (MMT) as determined by morphologic and biochemical techniques ..Partial characterization of relevant signaling pathways identified Erk1/2 activation, which was enhanced by combined TGF-b1/IL-6 administration, as a crucial necessary factor in the transition.. PMID: 26825317
  10. Comparative Modulation of Levels of Oxidative Stress in the Liver of Anti-Tuberculosis Drug Treated Wistar Rats by Vitamin B12, Beta-Carotene, and Spirulina fusiformis: Role of NF-kappaB, iNOS, IL-6, and IL-10.( PMID: 28387444
  11. An intracellular adrenomedullin system reduces IL-6 release via a NF-kB-mediated, cAMP-independent transcriptional mechanism in rat thymic epithelial cells. PMID: 27619517
  12. Crocin attenuate Tumor Necrosis Factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in streptozotocin-induced diabetic rat aorta/ PMID: 27529541
  13. Administration of Methylglyoxal led to depletion of antioxidant enzymes, induction of fibrosis (p < 0.001), up-regulated expression of RAGE (3.5 fold), TGF-beta (4.4 fold), SMAD2 (3.7 fold), SMAD3 (6.0 fold), IL-6 (4.3 fold) and TNF-alpha (5.5 fold) in the heart tissues compared to control rats. PMID: 28091942
  14. After being treated with calcitriol following hemorrhagic shock resulted in better survival rate, lower serum levels of TNF-alpha and IL-6, and lesser hepatic, renal, and pulmonary histo-pathologic scores of injury in rats. PMID: 27180201
  15. TNF-alpha, IL-6 and IL-10 expressions, responsible for disparity in action of curcumin against cisplatin-induced nephrotoxicity in rats. PMID: 28258441
  16. there may be dysregulation in IL-6 production from astrocytes. PMID: 27539920
  17. Local cryotherapy's local and systemic anti-inflammatory effects are mainly IL-6/IL-17A-driven and TNF-alpha independent in the adjuvant-induced arthritis model PMID: 28759646
  18. This study suggests direct stimulation of autophagy as a novel mechanism for IL-6-mediated protection of beta cells from stress-induced apoptosis. PMID: 28592636
  19. These data support prior findings suggesting that IL-6 mediates the leptin-sensitizing effects of amylin on VMN neurons and that the inherent leptin resistance of DIO rats can be effectively reversed at a cellular level by IL-6. PMID: 27534878
  20. Exercise combined with ultrasound attenuates neuropathic pain in rats and is associated with downregulation of IL-6 and TNF-alpha, and with upregulation of IL-10. PMID: 28319508
  21. Two-way ANOVA showed an interaction of prenatal low protein and postnatal high fat energy diet on IL-6 and IL-1beta transcription. PMID: 28141871
  22. Study provided preliminary evidence showing that high frequency vagal stimulation attenuates the expression of early onset pro-inflammatory cytokines IL-6 and TNFalpha in a neonatal rat model of airway infection. PMID: 27049312
  23. Overexpression of IL-6 is sufficient to induce myofibroblastic proliferation, differentiation, and fibrosis, probably via increased TGF-beta1-mediated MMP2/MMP3 signaling during ischemic myocardial remodeling monoculture or coculture models under hypoxic conditions. PMID: 27348628
  24. this paper shows that antidepressant rhodioloside decreased pro-inflammatory cytokine interleukin-6 PMID: 27214337
  25. Data show that cardiac arrest (CA) increased HIF-1alpha and pro-inflammatory cytokines (PICs) including IL-6 and TNF-alpha in the hippocampus CA1 region. PMID: 27383646
  26. the release of IL6 from MSCs was regulated via the TLR2/NFkappaB signalling pathway. Endogenous IL6 reduced apoptosis and protected OGDinjured PC12 cells when they were cocultured with MSCs. PMID: 27108485
  27. The levels of TNF-alpha and IL-6 and the intestinal wet/dry weight ratios were higher in the subarachnoid hemorrhage groups compared to the control group. PMID: 27993875
  28. low-level laser therapy (LLLT) administered following muscle injury modulates the mRNA expression of MyoD and myogenin. Moreover, the both forms of LLLT administration were able to modulate the mRNA expression of IL-6 during the muscle repair process. PMID: 26914683
  29. our results indicate that UC-MSCs can alleviate insulin resistance in part via production of IL-6 that elicits M2 polarization. Additionally, human obesity and insulin resistance were associated with increased pro-inflammatory ATMs infiltration. Thus, MSCs may be a new treatment for obesity-related insulin resistance and T2D concerning macrophage polarized effects PMID: 26523620
  30. Results suggest that activated-p38[alpha]-regulated IL-6 synthesis constitutes a neuroprotective mechanism of NaHS against oxygen-glucose deprivation/reoxygenation-induced neuronal injury in PC12 cells PMID: 26760196
  31. decrease in all groups after manipulation. Data show that the postoperative interleukin 6 (IL-6) levels were significantly increased in the conventional cecum resection (CCR) group compared to the laparoscopic cecum resection (LCR) group. PMID: 26846568
  32. Ang III, similar to Ang II, has pro-inflammatory effects since it induces STAT3 leading to an induction of IL-6 mRNA expression. PMID: 24961501
  33. the adenylyl cyclase/cAMP/PKA pathway upregulates IL-1beta-induced IL-6 synthesis through enhancement of the JAK2/STAT3 pathway in C6 glioma cells PMID: 26527061
  34. LPS significantly increased the supernatant TNF-alpha and IL-6 concentrations and reduced TH protein expression in PC12 cells, while silencing Nogo-A could block these effects PMID: 26583134
  35. Data show that expressions of vascular endothelial growth factor, interleukin 6, but not toll-like receptor 4 were modulated in everolimus-treated group. PMID: 26390417
  36. Data show that the ratio of peripheral blood CD4(+)/CD8(+) T lymphocytes and the levels of connexin-40 (Cx40), interleukins IL-2, IL-4 and IL-6 are significantly elevated in SH rats. PMID: 26927369
  37. Data show pioglitazone inhibits inflammatory reaction by up-regulating the level of peroxisome proliferator activated receptor gamma (PPARgamma) mRNA and down-regulating the levels of inflammatory cytokines TNF-alpha and IL-6 mRNAs in traumatic brain injury (TBI). PMID: 26927377
  38. Diabetic rats show an increase in the contractions of distal colon partly via the IL-6-IL-6 receptor pathway. PMID: 26191141
  39. REV-ERBalpha has a role in circadian oscillation in the expressions of Alas1, Ppargc1a, and Il6 genes in rat granulosa cells PMID: 26102301
  40. Data show that the negative regulation of cardiac fibroblasts (CFs) differentiation by qiliqiangxin (QL) through an interleukin-6(IL-6) transcriptional mechanism. PMID: 25752645
  41. IL-6 activates PI3K and PKCzeta signaling and determines cardiac differentiation in rat embryonic H9c2 cells PMID: 26205888
  42. Knockdown of IL-1Beta increased IL-6 expression in cerebral hypoxia-ischemia. PMID: 24965599
  43. Early increase of calpain-2 in L5-ventral root transection rats might be responsible for the induction of allodynia via up-regulating IL-6 in DRG neurons. PMID: 25150005
  44. HGF differentially regulates IL-6 production in hepatocytes (induces) versus immune cells (suppresses), signifying disparate regulation of the cell sources involved in IL-6 production is a biologically relevant mechanism. PMID: 24763697
  45. Neuromodulatory effects of interleukin-6 (IL-6) and corticotropin-releasing factor receptor (CRFR) 1 in visceral pain and stress-induced defecation in the WKY rat model of irritable bowel syndrome were investigated. PMID: 25260633
  46. Studied Sporothrix schenckii induction of release of tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-6 and activation of the extracellular signal-regulated kinase (ERK) signaling pathway in mast cells. PMID: 25262023
  47. S100beta-positive dendritic-like cells can sense an increase in extracellular protons via GPR68 and respond by the production of IL-6 in order to suppress the up-regulation of Pomc expression. PMID: 25129106
  48. Interleukin 6 (IL-6) levels rapidly increased within 24 h after SAH, reached a peak 24 h after SAH, and decreased slightly at 48 h. SOCS-3 was involved in cerebral vasospasm after subarachnoid hemorrhage via an IL-6- and IL-10-related mechanism. PMID: 24463741
  49. The neuronal apoptosis rate was positively correlated with the levels of TNF-alpha and IL-6, and negatively correlated with IL-10 and GDNF. PMID: 24706318
  50. The continuing increase in the production of IL-6 in culture was accompanied by a decreased formation of erythroblastic islets de novo. PMID: 25682689

Show More

Hide All

Subcellular Location Secreted
Protein Families IL-6 superfamily
Database Links

KEGG: rno:24498

STRING: 10116.ENSRNOP00000013732

UniGene: Rn.9873

  Tel: 301-363-4651
  Email: [email protected]
  Distributors Worldwide


Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

© 2007-2021 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1