Function
(From Uniprot) |
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation (By similarity).
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| Gene References into Functions |
- In summary, this study demonstrated that IL-6 enhances mitochondrial biogenesis and survival in astrocytes under experimental septic conditions. Additionally, IL-6 plays the pro-survival role through IL-6/AMPK signaling pathway. PMID:
29674256
- Aerobic exercise improves the lipid metabolism disorder and interferes with germ cell apoptosis by reducing interleukin-6 and interleukin-6 receptor expression in nutritional obesity rat model. PMID:
28776758
- These findings indicated that IL-6 might exert dual effects on tendon-derived stem cells in vitro: strongly enhancing their proliferation but inhibiting their tenogenic differentiation via the JAK/Stat3 pathway. PMID:
29547593
- in adjuvant arthritis fibroblast-like synoviocytes, MeCP2 mediates hypermethylation of PTCH1 gene and decreases the expression of PTCH1 protein, thus activating Hedgehog signaling pathway and increasing secretion of IL-6 and TNF-alpha. PMID:
28573530
- IL-6 expression increased in all groups compared to control. Lgr5 expression was up-regulated in cells exposed to a single stressor, but down-regulated when multiple stressors were administered. PMID:
29018960
- IL-6 synthesis and secretion were connected to acute peritoneal dialysis fluid exposure, and this response was triggered by TRPA1 receptors, possibly located to non-neuronal cells. PMID:
28698251
- The interleukin 6 (IL-6)-174 polymorphism was significantly associated with prostate cancer in Slovak patients. PMID:
29848725
- The present study demonstrated that IL-6 RNA interference may protect the lung from acute lung injury induced by intestinal ischemia/reperfusion, and that this protective role may be associated with upregulation of IL-10. PMID:
28713893
- In the present study, isolated rat peritoneal mesothelial cells were treated with TGF-beta1 and/or IL-6 which elicited mesenchymal transition (MMT) as determined by morphologic and biochemical techniques ..Partial characterization of relevant signaling pathways identified Erk1/2 activation, which was enhanced by combined TGF-b1/IL-6 administration, as a crucial necessary factor in the transition.. PMID:
26825317
- Comparative Modulation of Levels of Oxidative Stress in the Liver of Anti-Tuberculosis Drug Treated Wistar Rats by Vitamin B12, Beta-Carotene, and Spirulina fusiformis: Role of NF-kappaB, iNOS, IL-6, and IL-10.( PMID:
28387444
- An intracellular adrenomedullin system reduces IL-6 release via a NF-kB-mediated, cAMP-independent transcriptional mechanism in rat thymic epithelial cells. PMID:
27619517
- Crocin attenuate Tumor Necrosis Factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in streptozotocin-induced diabetic rat aorta/ PMID:
27529541
- Administration of Methylglyoxal led to depletion of antioxidant enzymes, induction of fibrosis (p < 0.001), up-regulated expression of RAGE (3.5 fold), TGF-beta (4.4 fold), SMAD2 (3.7 fold), SMAD3 (6.0 fold), IL-6 (4.3 fold) and TNF-alpha (5.5 fold) in the heart tissues compared to control rats. PMID:
28091942
- After being treated with calcitriol following hemorrhagic shock resulted in better survival rate, lower serum levels of TNF-alpha and IL-6, and lesser hepatic, renal, and pulmonary histo-pathologic scores of injury in rats. PMID:
27180201
- TNF-alpha, IL-6 and IL-10 expressions, responsible for disparity in action of curcumin against cisplatin-induced nephrotoxicity in rats. PMID:
28258441
- there may be dysregulation in IL-6 production from astrocytes. PMID:
27539920
- Local cryotherapy's local and systemic anti-inflammatory effects are mainly IL-6/IL-17A-driven and TNF-alpha independent in the adjuvant-induced arthritis model PMID:
28759646
- This study suggests direct stimulation of autophagy as a novel mechanism for IL-6-mediated protection of beta cells from stress-induced apoptosis. PMID:
28592636
- These data support prior findings suggesting that IL-6 mediates the leptin-sensitizing effects of amylin on VMN neurons and that the inherent leptin resistance of DIO rats can be effectively reversed at a cellular level by IL-6. PMID:
27534878
- Exercise combined with ultrasound attenuates neuropathic pain in rats and is associated with downregulation of IL-6 and TNF-alpha, and with upregulation of IL-10. PMID:
28319508
- Two-way ANOVA showed an interaction of prenatal low protein and postnatal high fat energy diet on IL-6 and IL-1beta transcription. PMID:
28141871
- Study provided preliminary evidence showing that high frequency vagal stimulation attenuates the expression of early onset pro-inflammatory cytokines IL-6 and TNFalpha in a neonatal rat model of airway infection. PMID:
27049312
- Overexpression of IL-6 is sufficient to induce myofibroblastic proliferation, differentiation, and fibrosis, probably via increased TGF-beta1-mediated MMP2/MMP3 signaling during ischemic myocardial remodeling monoculture or coculture models under hypoxic conditions. PMID:
27348628
- this paper shows that antidepressant rhodioloside decreased pro-inflammatory cytokine interleukin-6 PMID:
27214337
- Data show that cardiac arrest (CA) increased HIF-1alpha and pro-inflammatory cytokines (PICs) including IL-6 and TNF-alpha in the hippocampus CA1 region. PMID:
27383646
- the release of IL6 from MSCs was regulated via the TLR2/NFkappaB signalling pathway. Endogenous IL6 reduced apoptosis and protected OGDinjured PC12 cells when they were cocultured with MSCs. PMID:
27108485
- The levels of TNF-alpha and IL-6 and the intestinal wet/dry weight ratios were higher in the subarachnoid hemorrhage groups compared to the control group. PMID:
27993875
- low-level laser therapy (LLLT) administered following muscle injury modulates the mRNA expression of MyoD and myogenin. Moreover, the both forms of LLLT administration were able to modulate the mRNA expression of IL-6 during the muscle repair process. PMID:
26914683
- our results indicate that UC-MSCs can alleviate insulin resistance in part via production of IL-6 that elicits M2 polarization. Additionally, human obesity and insulin resistance were associated with increased pro-inflammatory ATMs infiltration. Thus, MSCs may be a new treatment for obesity-related insulin resistance and T2D concerning macrophage polarized effects PMID:
26523620
- Results suggest that activated-p38[alpha]-regulated IL-6 synthesis constitutes a neuroprotective mechanism of NaHS against oxygen-glucose deprivation/reoxygenation-induced neuronal injury in PC12 cells PMID:
26760196
- decrease in all groups after manipulation. Data show that the postoperative interleukin 6 (IL-6) levels were significantly increased in the conventional cecum resection (CCR) group compared to the laparoscopic cecum resection (LCR) group. PMID:
26846568
- Ang III, similar to Ang II, has pro-inflammatory effects since it induces STAT3 leading to an induction of IL-6 mRNA expression. PMID:
24961501
- the adenylyl cyclase/cAMP/PKA pathway upregulates IL-1beta-induced IL-6 synthesis through enhancement of the JAK2/STAT3 pathway in C6 glioma cells PMID:
26527061
- LPS significantly increased the supernatant TNF-alpha and IL-6 concentrations and reduced TH protein expression in PC12 cells, while silencing Nogo-A could block these effects PMID:
26583134
- Data show that expressions of vascular endothelial growth factor, interleukin 6, but not toll-like receptor 4 were modulated in everolimus-treated group. PMID:
26390417
- Data show that the ratio of peripheral blood CD4(+)/CD8(+) T lymphocytes and the levels of connexin-40 (Cx40), interleukins IL-2, IL-4 and IL-6 are significantly elevated in SH rats. PMID:
26927369
- Data show pioglitazone inhibits inflammatory reaction by up-regulating the level of peroxisome proliferator activated receptor gamma (PPARgamma) mRNA and down-regulating the levels of inflammatory cytokines TNF-alpha and IL-6 mRNAs in traumatic brain injury (TBI). PMID:
26927377
- Diabetic rats show an increase in the contractions of distal colon partly via the IL-6-IL-6 receptor pathway. PMID:
26191141
- REV-ERBalpha has a role in circadian oscillation in the expressions of Alas1, Ppargc1a, and Il6 genes in rat granulosa cells PMID:
26102301
- Data show that the negative regulation of cardiac fibroblasts (CFs) differentiation by qiliqiangxin (QL) through an interleukin-6(IL-6) transcriptional mechanism. PMID:
25752645
- IL-6 activates PI3K and PKCzeta signaling and determines cardiac differentiation in rat embryonic H9c2 cells PMID:
26205888
- Knockdown of IL-1Beta increased IL-6 expression in cerebral hypoxia-ischemia. PMID:
24965599
- Early increase of calpain-2 in L5-ventral root transection rats might be responsible for the induction of allodynia via up-regulating IL-6 in DRG neurons. PMID:
25150005
- HGF differentially regulates IL-6 production in hepatocytes (induces) versus immune cells (suppresses), signifying disparate regulation of the cell sources involved in IL-6 production is a biologically relevant mechanism. PMID:
24763697
- Neuromodulatory effects of interleukin-6 (IL-6) and corticotropin-releasing factor receptor (CRFR) 1 in visceral pain and stress-induced defecation in the WKY rat model of irritable bowel syndrome were investigated. PMID:
25260633
- Studied Sporothrix schenckii induction of release of tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-6 and activation of the extracellular signal-regulated kinase (ERK) signaling pathway in mast cells. PMID:
25262023
- S100beta-positive dendritic-like cells can sense an increase in extracellular protons via GPR68 and respond by the production of IL-6 in order to suppress the up-regulation of Pomc expression. PMID:
25129106
- Interleukin 6 (IL-6) levels rapidly increased within 24 h after SAH, reached a peak 24 h after SAH, and decreased slightly at 48 h. SOCS-3 was involved in cerebral vasospasm after subarachnoid hemorrhage via an IL-6- and IL-10-related mechanism. PMID:
24463741
- The neuronal apoptosis rate was positively correlated with the levels of TNF-alpha and IL-6, and negatively correlated with IL-10 and GDNF. PMID:
24706318
- The continuing increase in the production of IL-6 in culture was accompanied by a decreased formation of erythroblastic islets de novo. PMID:
25682689
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