IL6

IL-6 (Interleukin-6) is a glycoprotein composed of 184 amino acid residues with a molecular weight ranging from approximately 21 to 26 kDa. It contains four cysteine residues that form two intramolecular disulfide bonds, stabilizing its structure. IL-6 can be secreted in a free form or in complex with the soluble IL-6 receptor (sIL-6R). IL-6 exhibits a diverse array of biological functions, including but not limited to immune regulation, inflammatory responses, and hematopoiesis. Specifically, IL-6 promotes the proliferation and differentiation of hematopoietic stem cells in the bone marrow, participating in the production of blood components such as red blood cells and platelets. IL-6 is closely associated with the occurrence and development of various diseases, such as rheumatoid arthritis, multiple sclerosis, diabetes, cardiovascular diseases, and certain types of tumors. The signaling transduction of IL-6 is primarily achieved through two pathways: the classical signaling pathway and the trans-signaling pathway. In the classical signaling pathway, IL-6 first binds to the membrane-bound IL-6 receptor (mIL-6R), subsequently recruiting and activating the gp130 molecule, a signal transduction protein. The activated gp130 triggers the phosphorylation of JAK (Janus kinase), leading to the activation of STAT3 (Signal Transducer and Activator of Transcription 3). Activated STAT3 enters the nucleus to regulate gene expression. On the other hand, in cells lacking mIL-6R, IL-6 can bind to sIL-6R, forming an IL-6/sIL-6R complex. This complex subsequently binds to and activates gp130 on the cell surface. The trans-signaling pathway enables IL-6 to exert its effects in a broader range of cell types. Abnormal IL-6 expression and signaling can lead to the occurrence and progression of diseases. Therefore, in-depth research on IL-6 holds promise for a better understanding of its role in diseases and may provide new insights and approaches for disease treatment.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is 58 - 295 pg/mL.

IL6 Recombinant Monoclonal Antibody (CSB-RA011664MA1HU)

Validated Data

The Binding Activity of Human IL6 with Anti-IL6 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human IL6 (CSB-YP011664HU) at 2 μg/mL can bind Anti-IL6 recombinant antibody. The EC₅₀ is 35.80-41.82 ng/mL.

Human Interleukin 6,IL-6 ELISA KIT (CSB-E04638h)

Validated Data

Code: CSB-E04638h

Size: 48T/ 96T

Sensitivity: 2.453 pg/mL

Detection Range: 7.8 pg/mL-500 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following IL6 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

IL6 Antibodies

IL6 Proteins

IL6 ELISA Kits

IL6 Antibodies

IL6 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA06757B0Rb	IL6 Antibody, HRP conjugated	Human	ELISA
CSB-PA06757C0Rb	IL6 Antibody, FITC conjugated	Human
CSB-PA06757A0Rb	IL6 Antibody	Human, Mouse	ELISA, WB, IHC
CSB-PA06757D0Rb	IL6 Antibody, Biotin conjugated	Human	ELISA
CSB-PA005546	IL6 Antibody	Human	WB, ELISA
CSB-RA011664MA1HU	IL6 Recombinant Monoclonal Antibody	Human	ELISA
CSB-RA011664MA2HU	IL6 Recombinant Monoclonal Antibody	Human	ELISA, IHC

IL6 Antibodies for Macaca thibetana (Pere David's macaque) (Tibetan macaque)

Code	Product Name	Species Reactivity	Application
CSB-PA686313XA01FVG	IL6 Antibody	Macaca thibetana (Pere David's macaque) (Tibetan macaque)	ELISA, WB (ensure identification of antigen)

IL6 Antibodies for Ovis aries (Sheep)

Code	Product Name	Species Reactivity	Application
CSB-PA011664ZA01SH	IL6 Antibody	Ovis aries	ELISA, WB (ensure identification of antigen)

IL6 Proteins

IL6 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP011664BO CSB-BP011664BO CSB-MP011664BO CSB-EP011664BO-B	Recombinant Bovine Interleukin-6 (IL6)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL6 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Source
CSB-YP011664DO CSB-EP011664DO CSB-BP011664DO CSB-MP011664DO CSB-EP011664DO-B	Recombinant Dog Interleukin-6 (IL6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL6 Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-YP011664PI CSB-EP011664PI CSB-BP011664PI CSB-MP011664PI CSB-EP011664PI-B	Recombinant Pig Interleukin-6 (IL6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL6 Proteins for Ovis aries (Sheep)

Code	Product Name	Source
CSB-EP011664SH	Recombinant Sheep Interleukin-6 (IL6)	E.coli
CSB-YP011664SH	Recombinant Sheep Interleukin-6 (IL6)	Yeast
CSB-BP011664SH CSB-MP011664SH CSB-EP011664SH-B	Recombinant Sheep Interleukin-6 (IL6)	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL6 Proteins for Felis catus (Cat) (Felis silvestris catus)

Code	Product Name	Source
CSB-YP011664CA CSB-EP011664CA CSB-BP011664CA CSB-MP011664CA CSB-EP011664CA-B	Recombinant Cat Interleukin-6 (IL6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL6 Proteins for Macaca mulatta (Rhesus macaque)

Code	Product Name	Source
CSB-YP011664MOW CSB-EP011664MOW CSB-BP011664MOW CSB-MP011664MOW CSB-EP011664MOW-B	Recombinant Macaca mulatta (Rhesus macaque) Interleukin-6 (IL6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-AP003101MOW	Recombinant Macaca mulatta Interleukin-6 protein (IL6)	E.Coli

IL6 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-BP011664HU CSB-MP011664HU CSB-EP011664HU-B	Recombinant Human Interleukin-6 (IL6)	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-AP001741HU	Recombinant Human Interleukin-6 protein (IL6) (Active)	E.coli
CSB-RP067544h	Recombinant Human Interleukin-6 (IL6)	E.coli
CSB-AP004301HU	Recombinant Human Interleukin-6 (IL6) (Active)	E.coli
CSB-AP005841HU	Recombinant Human Interleukin-6 (IL6) (Active) (GMP)	E.Coli
CSB-EP011664HU	Recombinant Human Interleukin-6 (IL6) (Active)	E.coli
CSB-YP011664HU	Recombinant Human Interleukin-6 (IL6) (Active)	Yeast
CSB-MP011664HU-B	Recombinant Human Interleukin-6 (IL6), Biotinylated	Mammalian cell
CSB-EP011664HUe1	Recombinant Human Interleukin-6 (IL6)	E.coli
CSB-MP011664HU-WD	Recombinant Human Interleukin-6 (IL6) (Active)	Mammalian cell

IL6 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP011664MO CSB-EP011664MO CSB-BP011664MO CSB-MP011664MO CSB-EP011664MO-B	Recombinant Mouse Interleukin-6 (Il6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-AP003321MO	Recombinant Mouse Interleukin-6 protein (Il6) (Active)	E.Coli

IL6 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Code	Product Name	Source
CSB-YP305249MOV CSB-EP305249MOV CSB-BP305249MOV CSB-MP305249MOV CSB-EP305249MOV-B	Recombinant Macaca fascicularis Interleukin-6 (IL6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL6 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP322670RA CSB-EP322670RA CSB-BP322670RA CSB-MP322670RA CSB-EP322670RA-B	Recombinant Rat Interleukin-6 (Il6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL6 Proteins for Neovison vison (American mink) (Mustela vison)

Code	Product Name	Source
CSB-YP336891MVE CSB-EP336891MVE CSB-BP336891MVE CSB-MP336891MVE CSB-EP336891MVE-B	Recombinant Mustela vison Interleukin-6 (IL6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL6 Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)

Code	Product Name	Source
CSB-YP342020DRI CSB-EP342020DRI CSB-BP342020DRI CSB-MP342020DRI CSB-EP342020DRI-B	Recombinant Cercocebus atys Interleukin-6 (IL6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL6 Proteins for Mustela putorius furo (European domestic ferret) (Mustela furo)

Code	Product Name	Source
CSB-YP385261MOH CSB-EP385261MOH CSB-BP385261MOH CSB-MP385261MOH CSB-EP385261MOH-B	Recombinant Mustela putorius furo Interleukin-6 (IL6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL6 Proteins for Sparus aurata (Gilthead sea bream)

Code	Product Name	Source
CSB-YP466936FJX CSB-EP466936FJX CSB-BP466936FJX CSB-MP466936FJX CSB-EP466936FJX-B	Recombinant Sparus aurata Interleukin-6 (il6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL6 Proteins for Marmota monax (Woodchuck)

Code	Product Name	Source
CSB-YP518577MQG CSB-EP518577MQG CSB-BP518577MQG CSB-MP518577MQG CSB-EP518577MQG-B	Recombinant Marmota monax Interleukin-6 (IL6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL6 Proteins for Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)

Code	Product Name	Source
CSB-YP610956OEI CSB-EP610956OEI CSB-BP610956OEI CSB-MP610956OEI CSB-EP610956OEI-B	Recombinant Oncorhynchus mykiss Interleukin-6 (il6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL6 Proteins for Orcinus orca (Killer whale)

Code	Product Name	Source
CSB-YP630696OEP CSB-EP630696OEP CSB-BP630696OEP CSB-MP630696OEP CSB-EP630696OEP-B	Recombinant Orcinus orca Interleukin-6 (IL6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL6 Proteins for Capra hircus (Goat)

Code	Product Name	Source
CSB-YP631708GO CSB-EP631708GO CSB-BP631708GO CSB-MP631708GO CSB-EP631708GO-B	Recombinant Goat Interleukin-6 (IL6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL6 Proteins for Phoca vitulina (Harbor seal)

Code	Product Name	Source
CSB-YP631730EUR CSB-EP631730EUR CSB-BP631730EUR CSB-MP631730EUR CSB-EP631730EUR-B	Recombinant Phoca vitulina Interleukin-6 (IL6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL6 Proteins for Vulpes vulpes (Red fox)

Code	Product Name	Source
CSB-YP635622VFW CSB-EP635622VFW CSB-BP635622VFW CSB-MP635622VFW CSB-EP635622VFW-B	Recombinant Vulpes vulpes Interleukin-6 (IL6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL6 Proteins for Bubalus carabanensis (Swamp type water buffalo) (Bubalus bubalis carabanensis)

Code	Product Name	Source
CSB-YP640800BAAW CSB-EP640800BAAW CSB-BP640800BAAW CSB-MP640800BAAW CSB-EP640800BAAW-B	Recombinant Bubalus carabanensis Interleukin-6 (IL6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL6 Proteins for Macaca thibetana (Pere David's macaque) (Tibetan macaque)

Code	Product Name	Source
CSB-YP686313MDAO CSB-EP686313MDAO CSB-BP686313MDAO CSB-MP686313MDAO CSB-EP686313MDAO-B	Recombinant Macaca thibetana Interleukin-6 (IL6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL6 Proteins for Bubalus bubalis (Domestic water buffalo)

Code	Product Name	Source
CSB-YP740930BWX CSB-EP740930BWX CSB-BP740930BWX CSB-MP740930BWX CSB-EP740930BWX-B	Recombinant Bubalus bubalis Interleukin-6 (IL6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL6 Proteins for Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)

Code	Product Name	Source
CSB-YP760907TKY CSB-EP760907TKY CSB-BP760907TKY CSB-MP760907TKY CSB-EP760907TKY-B	Recombinant Takifugu rubripes Interleukin-6 (il6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL6 Proteins for Camelus bactrianus (Bactrian camel)

Code	Product Name	Source
CSB-YP772948CVZ CSB-EP772948CVZ CSB-BP772948CVZ CSB-MP772948CVZ CSB-EP772948CVZ-B	Recombinant Camelus bactrianus Interleukin-6 (IL6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL6 Proteins for Lama glama (Llama)

Code	Product Name	Source
CSB-YP803040LBS CSB-BP803040LBS CSB-EP803040LBS-B	Recombinant Lama glama Interleukin-6 (IL6)	Yeast Baculovirus In Vivo Biotinylation in E.coli

IL6 Proteins for Saimiri sciureus (Common squirrel monkey)

Code	Product Name	Source
CSB-YP847583SWD CSB-EP847583SWD CSB-BP847583SWD CSB-MP847583SWD CSB-EP847583SWD-B	Recombinant Saimiri sciureus Interleukin-6 (IL6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL6 Proteins for Gallus gallus (Chicken)

Code	Product Name	Source
CSB-YP856206CH CSB-EP856206CH CSB-BP856206CH CSB-MP856206CH CSB-EP856206CH-B	Recombinant Chicken Interleukin-6 (IL6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL6 Proteins for Equus caballus (Horse)

Code	Product Name	Source
CSB-YP856767HO CSB-EP856767HO CSB-BP856767HO CSB-MP856767HO CSB-EP856767HO-B	Recombinant Horse Interleukin-6 (IL6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL6 Proteins for Oryctolagus cuniculus (Rabbit)

Code	Product Name	Source
CSB-YP863071RB	Recombinant Rabbit Interleukin-6 (IL6)	Yeast
CSB-EP863071RB CSB-BP863071RB CSB-MP863071RB CSB-EP863071RB-B	Recombinant Rabbit Interleukin-6 (IL6)	E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL6 Proteins for Delphinapterus leucas (Beluga whale)

Code	Product Name	Source
CSB-YP893174DJB CSB-EP893174DJB CSB-BP893174DJB CSB-MP893174DJB CSB-EP893174DJB-B	Recombinant Delphinapterus leucas Interleukin-6 (IL6)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IL6 ELISA Kit

IL6 ELISA Kit for Bos taurus (Bovine)

Code	Product Name	Sample Types	Sensitivity
CSB-E12899B	Bovine Interleukin 6,IL-6 ELISA Kit	serum, plasma, tissue homogenates	2.5 pg/mL

IL6 ELISA Kit for Gallus gallus (Chicken)

Code	Product Name	Sample Types	Sensitivity
CSB-E08549Ch	Chicken Interleukin 6,IL-6 ELISA Kit	serum, plasma, tissue homogenates	3.9 pg/mL

IL6 ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Sample Types	Sensitivity
CSB-E11260c	Dog Interleukin 6,IL-6 ELISA Kit	serum, plasma, tissue homogenates	0.39 pg/mL

IL6 ELISA Kit for Capra hircus (Goat)

Code	Product Name	Sample Types	Sensitivity
CSB-E14360G	Goat Interleukin 6,IL-6 ELISA Kit	serum, plasma, tissue homogenates	0.39 pg/mL

IL6 ELISA Kit for Monkey

Code	Product Name	Sample Types	Sensitivity
CSB-E10050Mo	Monkey Interleukin 6,IL-6 ELISA Kit	serum, plasma, tissue homogenates	7.8 pg/mL

IL6 ELISA Kit for Mus musculus (Mouse)

Code	Product Name	Sample Types	Sensitivity
CSB-E04639m	Mouse Interleukin 6,IL-6 ELISA KIT

IL6 ELISA Kit for Sus scrofa (Pig)

Code	Product Name	Sample Types	Sensitivity
CSB-E06786p	Pig Interleukin 6,IL-6 ELISA Kit	serum, plasma, tissue homogenates	0.31 pg/mL

IL6 ELISA Kit for Oryctolagus cuniculus (Rabbit)

Code	Product Name	Sample Types	Sensitivity
CSB-E06903Rb	Rabbit Interleukin 6,IL-6 ELISA Kit	serum, plasma, tissue homogenates	3.9 pg/mL

IL6 ELISA Kit for Rattus norvegicus (Rat)

Code	Product Name	Sample Types	Sensitivity
CSB-E04640r	Rat Interleukin 6,IL-6 ELISA KIT	serum, plasma, tissue homogenates	0.078 pg/ml

IL6 ELISA Kit for Ovis aries (Sheep)

Code	Product Name	Sample Types	Sensitivity
CSB-E10116Sh	Sheep Interleukin 6,IL-6 ELISA Kit	serum, plasma, tissue homogenates	2 pg/mL

IL6 ELISA Kit for Fish

Code	Product Name	Sample Types	Sensitivity
CSB-E13258Fh	Fish Interleukin 6,IL-6 ELISA Kit	serum, plasma, tissue homogenates	12.5 pg/mL

IL6 ELISA Kit for Equus caballus (Horse)

Code	Product Name	Sample Types	Sensitivity
CSB-E16634Hs	Horse Interleukin 6(IL-6)ELISA Kit	serum, plasma, tissue homogenates	0.78 pg/mL

IL6 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E04638h	Human Interleukin 6,IL-6 ELISA KIT	serum, plasma, cell culture supernates, tissue homogenates, urine	2.453 pg/mL
CSB-E04638h-IS	Human Interleukin 6,IL-6 ELISA KIT	serum, plasma, cell culture supernates, tissue homogenates, saliva, urine	2.35pg/mL

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